Gold@Metal Sulfide (Noble Metal@Semiconductor) Nanoparticles: Enhancement of Laser Desorption/Ionization Efficiency via Plasmon-Exciton Coupling and Its Analytical Application in Mass Spectrometry

Professor Che, Chi Ming   (Principal Investigator (PI))

Dr Ng Kwan Ming   (Co-Investigator)

36

2017-08-01

522898

Gold@Metal Sulfide (Noble Metal@Semiconductor) Nanoparticles: Enhancement of Laser Desorption/Ionization Efficiency via Plasmon-Exciton Coupling and Its Analytical Application in Mass Spectrometry

Gold Nanoparticles, Laser Desorption/Ionization, Mass Spectrometry, Metal Sulfide Quantum Dot, Plasmon-Exciton Coupling

Mass Spectrometry,Chemical Sciences

Physical Sciences (P)

17306117

General Research Fund (GRF)

2017

Completed

1 To synthesize and characterize four types of Au@metal sulfide NPs, including Au@PbS, Au@Ag2S, Au@CdS and Au@ZnS NPs, with well control of Au core size (5 to 100 nm) and metal sulfide shell thickness (5 to 30 nm); 2 To investigate the effect of plasmon-exciton coupling on the LDI efficiency of the four types of NPs, including the effects of Au core size, and thickness and types of metal sulfide shell, on detection sensitivity for a variety of molecules; 3 To apply the promising NPs as efficient substrates for SALDI-MS-based bioanalytical applications, including the detection of illicit drugs in biological fluids, toxins in food, and profiling of peptides in cerebrospinal fluid.