Prevalence, genetic risk factor and the use of intradermally-administered inactivated influenza vaccine with topical imiquimod in influenza vaccine non-responsive children
Grant Data
Project Title
Prevalence, genetic risk factor and the use of intradermally-administered inactivated influenza vaccine with topical imiquimod in influenza vaccine non-responsive children
Principal Investigator
Dr Ip, Patrick
(Principal Investigator (PI))
Co-Investigator(s)
Professor Wong Ian Chi Kei
(Co-Investigator)
Chua Gilbert T
(Co-Investigator)
Professor Leung Wing Hang
(Co-Investigator)
Professor Hung Fan Ngai Ivan
(Co-Investigator)
Professor To Kelvin Kai Wang
(Co-Investigator)
Dr Kwokj Janette
(Co-Investigator)
Mr Tung Tsz Suen Keith
(Co-Investigator)
Mr Wong Wilfred Hing-sang
(Co-Investigator)
Dr Kwan Yat Wah
(Co-Investigator)
Duration
18
Start Date
2023-03-31
Conference Title
Prevalence, genetic risk factor and the use of intradermally-administered inactivated influenza vaccine with topical imiquimod in influenza vaccine non-responsive children
Keywords
influenza vaccine, topical imiquimod, Non-responsiveness, Seroconversion rate, children
Discipline
Paediatrics
HKU Project Code
21200242
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2022
Status
On-going
Objectives
The primary objective is to compare the vaccine responsiveness using intradermal (ID) inactivated influenza vaccine with and without pre-vaccination topical imiquimod (IIV-Q-ID and IIV-ID), and second dose of intramuscular IIV (IIV-IM) among paediatric IIV non-responders. The secondary objectives are to determine the prevalence of paediatric IIV non-responders, and the association between human leukocyte antigen (HLA) alleles and IIV non-responders.