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Article: Peripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy

TitlePeripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapy
Authors
KeywordsIMRT
Noncoplanar beams
Pediatric
Peripheral dose
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/meddos
Citation
Medical Dosimetry, 2010, v. 35 n. 4, p. 255-263 How to Cite?
AbstractThe use of noncoplanar intensity-modulated radiation therapy (IMRT) might result in better sparing of some critical organs because of a higher degree of freedom in beam angle optimization. However, this can lead to a potential increase in peripheral dose compared with coplanar IMRT. The peripheral dose from noncoplanar IMRT has not been previously quantified. This study examines the peripheral dose from noncoplanar IMRT compared with coplanar IMRT for pediatric radiation therapy. Five cases with different pediatric malignancies in head and neck were planned with both coplanar and noncoplanar IMRT techniques. The plans were performed such that the tumor coverage, conformality, and dose uniformity were comparable for both techniques. To measure the peripheral doses of the 2 techniques, thermoluminescent dosimeters (TLD) were placed in 10 different organs of a 5-year-old pediatric anthropomorphic phantom. With the use of noncoplanar beams, the peripheral doses to the spinal cord, bone marrow, lung, and breast were found to be 1.8-2.5 times of those using the coplanar technique. This is mainly because of the additional internal scatter dose from the noncoplanar beams. Although the use of noncoplanar technique can result in better sparing of certain organs such as the optic nerves, lens, or inner ears depending on how the beam angles were optimized on each patient, oncologists should be alert of the possibility of significantly increasing the peripheral doses to certain radiation-sensitive organs such as bone marrow and breast. This might increase the secondary cancer risk to patients at young age. © 2010 American Association of Medical Dosimetrists.
Persistent Identifierhttp://hdl.handle.net/10722/124621
ISSN
2023 Impact Factor: 1.1
2023 SCImago Journal Rankings: 0.425
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKan, MWKen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorWong, Wen_HK
dc.contributor.authorLam, Nen_HK
dc.date.accessioned2010-10-31T10:44:43Z-
dc.date.available2010-10-31T10:44:43Z-
dc.date.issued2010en_HK
dc.identifier.citationMedical Dosimetry, 2010, v. 35 n. 4, p. 255-263en_HK
dc.identifier.issn0958-3947en_HK
dc.identifier.urihttp://hdl.handle.net/10722/124621-
dc.description.abstractThe use of noncoplanar intensity-modulated radiation therapy (IMRT) might result in better sparing of some critical organs because of a higher degree of freedom in beam angle optimization. However, this can lead to a potential increase in peripheral dose compared with coplanar IMRT. The peripheral dose from noncoplanar IMRT has not been previously quantified. This study examines the peripheral dose from noncoplanar IMRT compared with coplanar IMRT for pediatric radiation therapy. Five cases with different pediatric malignancies in head and neck were planned with both coplanar and noncoplanar IMRT techniques. The plans were performed such that the tumor coverage, conformality, and dose uniformity were comparable for both techniques. To measure the peripheral doses of the 2 techniques, thermoluminescent dosimeters (TLD) were placed in 10 different organs of a 5-year-old pediatric anthropomorphic phantom. With the use of noncoplanar beams, the peripheral doses to the spinal cord, bone marrow, lung, and breast were found to be 1.8-2.5 times of those using the coplanar technique. This is mainly because of the additional internal scatter dose from the noncoplanar beams. Although the use of noncoplanar technique can result in better sparing of certain organs such as the optic nerves, lens, or inner ears depending on how the beam angles were optimized on each patient, oncologists should be alert of the possibility of significantly increasing the peripheral doses to certain radiation-sensitive organs such as bone marrow and breast. This might increase the secondary cancer risk to patients at young age. © 2010 American Association of Medical Dosimetrists.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/meddosen_HK
dc.relation.ispartofMedical Dosimetryen_HK
dc.subjectIMRT-
dc.subjectNoncoplanar beams-
dc.subjectPediatric-
dc.subjectPeripheral dose-
dc.subject.meshBody Burdenen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHead and Neck Neoplasms - radiotherapyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshMaleen_HK
dc.subject.meshRadiotherapy, Conformal - methodsen_HK
dc.subject.meshWhole-Body Counting - methodsen_HK
dc.titlePeripheral Doses from Noncoplanar IMRT for Pediatric Radiation Therapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0958-3947&volume=&spage=&epage=&date=2009&atitle=Peripheral+doses+from+noncoplanar+IMRT+for+pediatric+radiation+therapyen_HK
dc.identifier.emailKwong, DLW:dlwkwong@hku.hken_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.meddos.2009.07.003en_HK
dc.identifier.pmid19962878-
dc.identifier.scopuseid_2-s2.0-78049486766en_HK
dc.identifier.hkuros180266en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78049486766&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue4en_HK
dc.identifier.spage255en_HK
dc.identifier.epage263en_HK
dc.identifier.isiWOS:000284451800003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKan, MWK=36055443600en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridWong, W=7403972861en_HK
dc.identifier.scopusauthoridLam, N=23060896700en_HK
dc.identifier.citeulike5828151-
dc.identifier.issnl1873-4022-

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