Name Card

Professor Dora Kwong 鄺麗雲

Clinical Professor

Professional Qualifications
YearAwarding InstitutionQualification
1988The University of Hong KongMBBS
2006The University of Hong KongMD
1993The Royal College of RadiologistsFRCR
1996Hong Kong Academy of MedicineFHKCR
1996The Hong Kong Academy of MedicineFHKAM
1997The University of Wales SwanseaPostgraduate Diploma in Health Care Management

Prof. Dora Kwong is currently Clinical Professor and Head of Department of Clinical Oncology. Prof. Kwong graduated from the University of Hong Kong in 1988 and became Fellow of the Royal College of Radiologists in 1993 and Fellow of Hong Kong College of Radiologists and Fellow of Hong Kong Academy of Medicine in 1996. She obtained her Doctor of Medicine degree from the University of Hong Kong in 2006.

Her research interests include head and neck cancer with an emphasis on nasopharyngeal carcinoma (NPC), upper GI cancers including CA esophagus and CA stomach and paediatric cancers. She is involved in multiciplinary management employing both medical treatment and radiotherapy. She is also interested in basic research in carcinogenesis and translational research in identifying prognostic and predictor biomarkers.

For nasopharyngeal carcinoma, her randomised factorial study on concurrent and adjuvant chemotherapy in NPC is one of the studies included in metaanalysis of NPC which confirmed the importance of concurrent chemoradiotherapy in improving survival of NPC. She pioneered the use of intensity modulation radiotherapy (IMRT) in treatment of NPC in Hong Kong showing the advantage of IMRT in preserving salivary function, improving quality of life in early NPC and allowing dose escalation and improved local control in locally advanced NPC. Both concurrent chemoradiotherapy and IMRT have now been adopted as standard of care in treatment of NPC. Currently we are investigating the role of functional imaging like PET scan in predicting for early disease response and incorporating biological target volume in IMRT in order to adapt radiotherapy to individual disease response during treatment. In laboratory research, we studied the function of a number of novel tumor suppressor genes and found that hypermethylation is an important mechanism in inactivation of tumor suppressor genes.

The predominent histology of CA esophagus in Hong Kong is squamous cell carcinoma which is different from the adenocarcinoma which is more commonly seen in the West. We studied the genetic basis of carcinogenesis of squamous cell carcinoma of esophagus. We showed that chromosomal inbalance is common in CA esophagus and identify a number of areas which would habor novel oncogenes or tumor suppressor genes. We identify and characterize a novel tumor suppressor gene UPK1A in CA esophagus and found miRNA to be important in carcinogenesis. In clinical case management, we worked closely with the surgeons in multidisciplinary and multimodality treatment. Most cases are treated with pre-operative chemoradiation and then surgery. We aim to identify biomarkers which will predict response to pre-operative chemoradiotherapy.

Prof. Kwong also has a long standing interest in studying radiation complications like hearing loss, temporal lobe necrosis and xerostomia after radiotherapy and the ways to reduce such complications. We study advanced radiotherapy techniques like intensity modulated radiotherapy, adaptive radiotherapy and stereotactic body radiotherapy and promote their use of in clinical practice.

Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
2008-07-012008 Research Output Prize/Faculty Outstanding Research Output Award: The University of Hong Kong
Research Achievement
Cheung, TK
Yung, ST
2009-11-01Young Investigator Award In Psychosocial Oncology : Higher Education And Younger Age Are Associated With Better Understanding Of Clinical Trials Among Hong Kong Cancer Patients: 16th Hong Kong International Cancer Congress & 6th Annual Meeting Centre For Cancer Research
Research Achievement
LEE, Chi Hang
Chan, ASY
YUE, Siu Kuen
CHENG, Sze Wa Priscilla
Yuen, ST
Chan, KW
Tsui, WY
Chan, AS
Siu, HC
Man, HY
Chan, D
2018-12-01Research Output Prize 2019. A comprehensive human gastric cancer organoid biobank captures tumor subtype heterogeneity and enables therapeutic screening. Cell Stem Cell, 23, 2018.: The University of Hong Kong
Research Achievement
2012-08-31General Research Fund (GRF) 2012-13: HKU 768312M. Amount: HK$ 1,169,000: General Research Fund (GRF)
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
2019-2020PresidentHong Kong Head and Neck Society
2012-2018ChairmanHong Kong NPC Study Group
2019Organising and Scientific Committee ChairTrisociety Head and Neck Meeting
2000-nowMemberInternational Society for Diseases of the Esophagus
2011Scientific Committee of IAOO 3rd world congress 2011The International Academy of oral Oncology
2011Scientific CommitteeTrisociety Head and Neck Oncology Meeting
1996-nowMemberHong Kong Society of Radiation Oncology and Oncology
1996-nowMemberHong Kong Paediatric Haematology and Oncology Study Group
2000-nowMemberSociety of Clinical Oncology
1996-nowMemberHong Kong Anti-Cancer Society
1999-nowMemberHong Kong Nasopharyngeal Carcinoma Study Group
2010-nowExpert member in the Panel for Head and Neck Cancer and MusculoskeletalHong Kong Regional TNM Cancer Staging Subcommittee
2005-nowMemberAmerican Society for Therapeutic Radiology and Oncology
1996-nowFellowHong Kong Academy of Medicine
1996-now, 2000-2006Member, Honaonary treasurer, PresidentHong Kong Head and Neck Society
1996-now, 1999-2016, 2005-now, 2010-now, 2013Fellow, Scientific Committee and membership committee, part II tutor, Examiner, Council MemberHong Kong College of Radiologists
1993-nowFellowRoyal College of Radiologists
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