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Conference Paper: Importance of zinc-binding domain of matrix metalloproteinase 19 (MMP19) in tumor suppression and anti-angiogenesis of nasopharyngeal carcinoma
Title | Importance of zinc-binding domain of matrix metalloproteinase 19 (MMP19) in tumor suppression and anti-angiogenesis of nasopharyngeal carcinoma |
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Authors | |
Issue Date | 2010 |
Publisher | American Association for Cancer Research. |
Citation | The 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010. How to Cite? |
Abstract | BACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases consisting of more than 20 enzymes. MMP19 shares the typical MMP structural domains. It degrades various ECM components including collagen type IV, nidogen-1, fibronectin, tenascin-C isoform, aggrecan, and laminin-5-gamma-2-chain. In our previous studies, MMP19 was identified as a candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC). It was down-regulated in NPC cell lines and NPC biopsies, when compared to an immortalized normal nasopharyngeal epithelial cell line and corresponding non-tumor nasopharyngeal tissues. Transfection of wild-type (WT) MMP19 into the ... |
Description | Poster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3069 |
Persistent Identifier | http://hdl.handle.net/10722/126825 |
DC Field | Value | Language |
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dc.contributor.author | Chan, KC | en_HK |
dc.contributor.author | Ko, JMY | en_HK |
dc.contributor.author | Lung, HL | en_HK |
dc.contributor.author | Sedlacek, R | en_HK |
dc.contributor.author | Lung, ML | en_HK |
dc.date.accessioned | 2010-10-31T12:50:45Z | - |
dc.date.available | 2010-10-31T12:50:45Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | The 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010. | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/126825 | - |
dc.description | Poster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3069 | - |
dc.description.abstract | BACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases consisting of more than 20 enzymes. MMP19 shares the typical MMP structural domains. It degrades various ECM components including collagen type IV, nidogen-1, fibronectin, tenascin-C isoform, aggrecan, and laminin-5-gamma-2-chain. In our previous studies, MMP19 was identified as a candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC). It was down-regulated in NPC cell lines and NPC biopsies, when compared to an immortalized normal nasopharyngeal epithelial cell line and corresponding non-tumor nasopharyngeal tissues. Transfection of wild-type (WT) MMP19 into the ... | - |
dc.language | eng | en_HK |
dc.publisher | American Association for Cancer Research. | - |
dc.relation.ispartof | Annual Meeting of the American Association for Cancer Research, AACR 2010 | - |
dc.title | Importance of zinc-binding domain of matrix metalloproteinase 19 (MMP19) in tumor suppression and anti-angiogenesis of nasopharyngeal carcinoma | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Chan, KC: mentoscan@yahoo.com.hk | en_HK |
dc.identifier.email | Ko, JMY: joko@HKUCC-COM.hku.hk | en_HK |
dc.identifier.email | Lung, HL: hllung2@hku.hk | en_HK |
dc.identifier.email | Lung, ML: mlilung@hku.hk | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 170955 | en_HK |
dc.publisher.place | United States | - |
dc.description.other | The 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010. | - |