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Conference Paper: In vivo proton MRS of liver in an experimental liver fibrosis model
Title | In vivo proton MRS of liver in an experimental liver fibrosis model |
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Authors | |
Issue Date | 2010 |
Citation | The 2010 ISMRM-ESMRMB Joint Annual Meeting, Stockholm, Sweden, 1-7 May 2010. How to Cite? |
Abstract | Carbon tetrachloride (CCl4) intoxication is a well-characterized, reproducible and the most commonly used experimental model of liver fibrosis. Proton magnetic resonance spectroscopy (1H MRS) can provide insights into in vivo liver metabolism noninvasively, yet detailed in vivo MRS study of CCl4-induced liver fibrosis model has been limited. The aim of this study was to characterize early metabolic changes in CCl4-induced liver fibrosis in rodents by means of single-voxel 1H MRS. Our experimental results demonstrated that 1H MRS at high field may be valuable in characterizing metabolic changes in liver, in particular those related to lipid and glutamine metabolism, after CCl4 insult. |
Description | Posters - MRS - Body Applications: No. 4733 |
Persistent Identifier | http://hdl.handle.net/10722/129639 |
DC Field | Value | Language |
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dc.contributor.author | Cheung, JSC | en_US |
dc.contributor.author | Fan, SJ | en_US |
dc.contributor.author | Gao, DS | en_US |
dc.contributor.author | Chan, KWY | en_US |
dc.contributor.author | Chow, AMK | en_US |
dc.contributor.author | Man, K | en_US |
dc.contributor.author | Wu, EX | en_US |
dc.date.accessioned | 2010-12-23T08:40:37Z | - |
dc.date.available | 2010-12-23T08:40:37Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | The 2010 ISMRM-ESMRMB Joint Annual Meeting, Stockholm, Sweden, 1-7 May 2010. | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/129639 | - |
dc.description | Posters - MRS - Body Applications: No. 4733 | - |
dc.description.abstract | Carbon tetrachloride (CCl4) intoxication is a well-characterized, reproducible and the most commonly used experimental model of liver fibrosis. Proton magnetic resonance spectroscopy (1H MRS) can provide insights into in vivo liver metabolism noninvasively, yet detailed in vivo MRS study of CCl4-induced liver fibrosis model has been limited. The aim of this study was to characterize early metabolic changes in CCl4-induced liver fibrosis in rodents by means of single-voxel 1H MRS. Our experimental results demonstrated that 1H MRS at high field may be valuable in characterizing metabolic changes in liver, in particular those related to lipid and glutamine metabolism, after CCl4 insult. | - |
dc.language | eng | en_US |
dc.relation.ispartof | ISMRM-ESMRMB 2010 Joint Annual Meeting | - |
dc.title | In vivo proton MRS of liver in an experimental liver fibrosis model | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Chan, KWY: kannie@graduate.hku.hk | en_US |
dc.identifier.email | Chow, AMK: aprilcmk@hkusua.hku.hk | - |
dc.identifier.email | Man, K: kwanman@hkucc.hku.hk | - |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
dc.identifier.hkuros | 178241 | en_US |