Diffusion tensor shape measurements of infarcted myocardium in porcine models using three phase geometric analysis

Abstract

Previous DTI studies on infarcted LV myocardium structure usually investigated diffusivity and diffusion anisotropy. In current study, diffusion tensor shape with a combination of linear, planar and spherical measures are examined and illustrated on a three-phase space in porcine models. Results show that the measurements of tensor shape have significant alteration in infarcted myocardium and are more sensitive to detect subtle change of diffusion properties than conventionally used parameters. Infarct location shows no apparent influence on myocardium structural degradation. This study gives insights into myocardium structural alteration and demonstrates potential application of DTI in detecting infarcted heart remodeling.