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Article: Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis

TitleAbrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis
Authors
Wong, VCLKo, JMYQi, RZLi, PJWang, LDLi, JLChan, YPChan, KWStanbridge, EJLung, ML
Keywordscancer progression
deleted in oesophageal cancer 1 (DEC1)
oesophageal cancer family history
oesophageal squamous cell carcinoma
subcellular localisation
Issue Date2011
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 2011, v. 104 n. 5, p. 841-849 How to Cite?
DOI: http://dx.doi.org/10.1038/bjc.2011.25
AbstractBackground: Oesophageal squamous cell carcinoma (SCC) causes the highest number of cancer deaths in some regions of Northern China. Previously, we narrowed down a critical region at 9q33-34, identified to be associated with tumour-suppressive function of deleted in oesophageal cancer 1 (DEC1) in oesophageal SCC. Methods: We generated DEC1 antibody and constructed tissue microarrays (TMAs) utilising tissue specimens from Henan, a high-risk region for oesophageal SCC, to investigate the importance of DEC1 expression in this cancer. Results: Tissue microarray immunohistochemical staining reveals significant loss of DEC1 from hyperplasia, to tumour, and to lymph node metastasis. In addition, the loss of DEC1 in tumour is age-dependent. Interestingly, there is significant abrogation of DEC1 expression in patients with a family history of oesophageal SCC. Deleted in oesophageal cancer 1 localises to both the cytoplasm and nucleus. The vesicular pattern of DEC1 in the cytoplasm appears to localise at the Golgi and Golgi-endoplasmic reticulum intermediate compartment. Conclusion: This is the first TMA study to suggest a clinical association of DEC1 in lymph node metastatic oesophageal SCC, early onset oesophageal SCC and familial oesophageal SCC development. Subcellular localisation of DEC1 and its expression in oesophageal SCC tissues provide important insight for further deciphering the molecular mechanism of DEC1 in oesophageal SCC development. © 2011 Cancer Research UK All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/134903
ISSN
0007-0920
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 3.000
PubMed Central ID
PMC3048215
ISI Accession Number ID
WOS:000287918200013
Funding AgencyGrant Number
Research Grants Council of Hong Kong Special Administrative Region, People's Republic of China
Funding Information:

We acknowledge the Research Grants Council of Hong Kong Special Administrative Region, People's Republic of China for funding support to MLL. We acknowledge the University of Hong Kong Faculty of Medicine Core Facility for use of the confocal microscope.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWong, VCLen_HK
dc.contributor.authorKo, JMYen_HK
dc.contributor.authorQi, RZen_HK
dc.contributor.authorLi, PJen_HK
dc.contributor.authorWang, LDen_HK
dc.contributor.authorLi, JLen_HK
dc.contributor.authorChan, YPen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorStanbridge, EJen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2011-07-25T07:44:19Z-
dc.date.available2011-07-25T07:44:19Z-
dc.date.issued2011en_HK
dc.identifier.citationBritish Journal Of Cancer, 2011, v. 104 n. 5, p. 841-849en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134903-
dc.description.abstractBackground: Oesophageal squamous cell carcinoma (SCC) causes the highest number of cancer deaths in some regions of Northern China. Previously, we narrowed down a critical region at 9q33-34, identified to be associated with tumour-suppressive function of deleted in oesophageal cancer 1 (DEC1) in oesophageal SCC. Methods: We generated DEC1 antibody and constructed tissue microarrays (TMAs) utilising tissue specimens from Henan, a high-risk region for oesophageal SCC, to investigate the importance of DEC1 expression in this cancer. Results: Tissue microarray immunohistochemical staining reveals significant loss of DEC1 from hyperplasia, to tumour, and to lymph node metastasis. In addition, the loss of DEC1 in tumour is age-dependent. Interestingly, there is significant abrogation of DEC1 expression in patients with a family history of oesophageal SCC. Deleted in oesophageal cancer 1 localises to both the cytoplasm and nucleus. The vesicular pattern of DEC1 in the cytoplasm appears to localise at the Golgi and Golgi-endoplasmic reticulum intermediate compartment. Conclusion: This is the first TMA study to suggest a clinical association of DEC1 in lymph node metastatic oesophageal SCC, early onset oesophageal SCC and familial oesophageal SCC development. Subcellular localisation of DEC1 and its expression in oesophageal SCC tissues provide important insight for further deciphering the molecular mechanism of DEC1 in oesophageal SCC development. © 2011 Cancer Research UK All rights reserved.en_HK
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectcancer progressionen_HK
dc.subjectdeleted in oesophageal cancer 1 (DEC1)en_HK
dc.subjectoesophageal cancer family historyen_HK
dc.subjectoesophageal squamous cell carcinomaen_HK
dc.subjectsubcellular localisationen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - metabolism - pathology-
dc.subject.meshEsophageal Neoplasms - genetics - metabolism - pathology-
dc.subject.meshFamily Health-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshTumor Suppressor Proteins - metabolism-
dc.titleAbrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=104&issue=5&spage=841&epage=849&date=2011&atitle=Abrogated+expression+of+DEC1+during+oesophageal+squamous+cell+carcinoma+progression+is+age-+and+family+history-related+and+significantly+associated+with+lymph+node+metastasis-
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1038/bjc.2011.25en_HK
dc.identifier.pmid21326238-
dc.identifier.pmcidPMC3048215-
dc.identifier.scopuseid_2-s2.0-79952279945en_HK
dc.identifier.hkuros186362-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952279945&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue5en_HK
dc.identifier.spage841en_HK
dc.identifier.epage849en_HK
dc.identifier.isiWOS:000287918200013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, VCL=23096631300en_HK
dc.identifier.scopusauthoridKo, JMY=35725559400en_HK
dc.identifier.scopusauthoridQi, RZ=7006273649en_HK
dc.identifier.scopusauthoridLi, PJ=36082591400en_HK
dc.identifier.scopusauthoridWang, LD=37118029700en_HK
dc.identifier.scopusauthoridLi, JL=10839988300en_HK
dc.identifier.scopusauthoridChan, YP=14009821700en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridStanbridge, EJ=35726268300en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.citeulike8848384-
dc.identifier.issnl0007-0920-

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