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Article: SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
Title | SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model |
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Authors | |
Keywords | Aging Energy metabolism LKB1 Sirtuin Stress |
Issue Date | 2011 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet |
Citation | Febs Letters, 2011, v. 585 n. 7, p. 986-994 How to Cite? |
Abstract | Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reservedcells. |
Persistent Identifier | http://hdl.handle.net/10722/142456 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 1.208 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Y | en_HK |
dc.contributor.author | Liang, Y | en_HK |
dc.contributor.author | Vanhoutte, PM | en_HK |
dc.date.accessioned | 2011-10-28T02:46:30Z | - |
dc.date.available | 2011-10-28T02:46:30Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Febs Letters, 2011, v. 585 n. 7, p. 986-994 | en_HK |
dc.identifier.issn | 0014-5793 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/142456 | - |
dc.description.abstract | Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reservedcells. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet | en_HK |
dc.relation.ispartof | FEBS Letters | en_HK |
dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication in FEBS Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in FEBS Letters, 2011, v. 585 n. 7, p. 986-994. DOI: 10.1016/j.febslet.2010.11.047 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Aging | en_HK |
dc.subject | Energy metabolism | en_HK |
dc.subject | LKB1 | en_HK |
dc.subject | Sirtuin | en_HK |
dc.subject | Stress | en_HK |
dc.subject.mesh | AMP-Activated Protein Kinases - metabolism | - |
dc.subject.mesh | Cell Aging | - |
dc.subject.mesh | Models, Biological | - |
dc.subject.mesh | Signal Transduction | - |
dc.subject.mesh | Sirtuin 1 - metabolism | - |
dc.title | SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Wang, Y: yuwanghk@hku.hk | en_HK |
dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | en_HK |
dc.identifier.authority | Wang, Y=rp00239 | en_HK |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_HK |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.febslet.2010.11.047 | en_HK |
dc.identifier.pmid | 21130086 | - |
dc.identifier.scopus | eid_2-s2.0-79953239122 | en_HK |
dc.identifier.hkuros | 184378 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79953239122&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 585 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 986 | en_HK |
dc.identifier.epage | 994 | en_HK |
dc.identifier.isi | WOS:000289057800008 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Wang, Y=34973733700 | en_HK |
dc.identifier.scopusauthorid | Liang, Y=35305492300 | en_HK |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_HK |
dc.identifier.citeulike | 8367187 | - |
dc.identifier.issnl | 0014-5793 | - |