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Article: Prognostic significance of serum tumour markers in carcinoma of the cervix
Title | Prognostic significance of serum tumour markers in carcinoma of the cervix |
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Authors | |
Keywords | Carcinoma of the cervix Prognostic factors Tumour markers |
Issue Date | 1996 |
Publisher | I R O G Canada, Inc. The Journal's web site is located at http://www.irog.net/en-CA/index.aspx?CatID=4 |
Citation | European Journal Of Gynaecological Oncology, 1996, v. 17 n. 6, p. 512-517 How to Cite? |
Abstract | Purpose: The purpose was to evaluate the prognostic significance of serum tumour markers and other potential prognostic factors in cervical cancer. Materials and methods: Five hundred and thirty-one patients with cervical cancer were studied. The pre-treatment levels of SCC (squamous cell carcinoma antigen), TPA (tissue polypeptide antigen), CEA (carcinoembryonic antigen), CA125 and hCG (human chorionic gonadotrophin) were assayed in these patients. Possible association between raised tumour markers and potential prognostic factors and their prognostic significance were sought by univariate and multivariate Cox analysis. Results: SCC was raised in 65% of squamous cell carcinoma of the cervix and TPA was raised in 50%. Other markers were raised in less than 25%. No tumour markers were raised more than 30% in adenocarcinoma of the cervix. Raised SCC and TPA were related to advancing age, stage and grade of differentiation. Univariate analysis showed that age, stage, grade, raised SCC and TPA were significant prognostic factors on survival. Multivariate Cox analysis showed that stage was the most significant factor. Conclusion: Stage, age, grade of differentiation, raised pre-treatment levels of SCC and TPA were significant prognostic factors in cervical cancer using univariate analysis. However, only stage remains the most important independent prognostic factor in multivariate analysis. The prognostic value of these other factors in early stage disease needs further exploration. |
Persistent Identifier | http://hdl.handle.net/10722/148053 |
ISSN | 2023 Impact Factor: 0.5 2020 SCImago Journal Rankings: 0.150 |
References |
DC Field | Value | Language |
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dc.contributor.author | Ngan, HYS | en_HK |
dc.contributor.author | Cheung, ANY | en_HK |
dc.contributor.author | Lauder, IJ | en_HK |
dc.contributor.author | Wong, LC | en_HK |
dc.contributor.author | Ma, HK | en_HK |
dc.date.accessioned | 2012-05-29T06:10:36Z | - |
dc.date.available | 2012-05-29T06:10:36Z | - |
dc.date.issued | 1996 | en_HK |
dc.identifier.citation | European Journal Of Gynaecological Oncology, 1996, v. 17 n. 6, p. 512-517 | en_HK |
dc.identifier.issn | 0392-2936 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148053 | - |
dc.description.abstract | Purpose: The purpose was to evaluate the prognostic significance of serum tumour markers and other potential prognostic factors in cervical cancer. Materials and methods: Five hundred and thirty-one patients with cervical cancer were studied. The pre-treatment levels of SCC (squamous cell carcinoma antigen), TPA (tissue polypeptide antigen), CEA (carcinoembryonic antigen), CA125 and hCG (human chorionic gonadotrophin) were assayed in these patients. Possible association between raised tumour markers and potential prognostic factors and their prognostic significance were sought by univariate and multivariate Cox analysis. Results: SCC was raised in 65% of squamous cell carcinoma of the cervix and TPA was raised in 50%. Other markers were raised in less than 25%. No tumour markers were raised more than 30% in adenocarcinoma of the cervix. Raised SCC and TPA were related to advancing age, stage and grade of differentiation. Univariate analysis showed that age, stage, grade, raised SCC and TPA were significant prognostic factors on survival. Multivariate Cox analysis showed that stage was the most significant factor. Conclusion: Stage, age, grade of differentiation, raised pre-treatment levels of SCC and TPA were significant prognostic factors in cervical cancer using univariate analysis. However, only stage remains the most important independent prognostic factor in multivariate analysis. The prognostic value of these other factors in early stage disease needs further exploration. | en_HK |
dc.language | eng | en_US |
dc.publisher | I R O G Canada, Inc. The Journal's web site is located at http://www.irog.net/en-CA/index.aspx?CatID=4 | en_HK |
dc.relation.ispartof | European Journal of Gynaecological Oncology | en_HK |
dc.subject | Carcinoma of the cervix | en_HK |
dc.subject | Prognostic factors | en_HK |
dc.subject | Tumour markers | en_HK |
dc.subject.mesh | Adenocarcinoma - Diagnosis - Pathology - Physiopathology | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Carcinoma, Adenosquamous - Diagnosis - Pathology - Physiopathology | en_US |
dc.subject.mesh | Carcinoma, Squamous Cell - Diagnosis - Pathology - Physiopathology | en_US |
dc.subject.mesh | Chi-Square Distribution | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Radioimmunoassay | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.subject.mesh | Tumor Markers, Biological - Analysis - Blood | en_US |
dc.subject.mesh | Uterine Cervical Neoplasms - Diagnosis - Pathology - Physiopathology | en_US |
dc.title | Prognostic significance of serum tumour markers in carcinoma of the cervix | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ngan, HYS:hysngan@hkucc.hku.hk | en_HK |
dc.identifier.email | Cheung, ANY:anycheun@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ngan, HYS=rp00346 | en_HK |
dc.identifier.authority | Cheung, ANY=rp00542 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 8971531 | - |
dc.identifier.scopus | eid_2-s2.0-0029800867 | en_HK |
dc.identifier.hkuros | 21825 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0029800867&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 17 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 512 | en_HK |
dc.identifier.epage | 517 | en_HK |
dc.publisher.place | Canada | en_HK |
dc.identifier.scopusauthorid | Ngan, HYS=34571944100 | en_HK |
dc.identifier.scopusauthorid | Cheung, ANY=54927484100 | en_HK |
dc.identifier.scopusauthorid | Lauder, IJ=35564928000 | en_HK |
dc.identifier.scopusauthorid | Wong, LC=7402092003 | en_HK |
dc.identifier.scopusauthorid | Ma, HK=7403095603 | en_HK |
dc.identifier.issnl | 0392-2936 | - |