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- Publisher Website: 10.1097/00004347-199810000-00009
- Scopus: eid_2-s2.0-0031720088
- PMID: 9785136
- WOS: WOS:000076158600009
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Article: Ovarian mature cystic teratoma with malignant transformation: An interphase cytogenetic study
Title | Ovarian mature cystic teratoma with malignant transformation: An interphase cytogenetic study |
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Authors | |
Keywords | Cytogenetic analysis Dermoid cyst Malignant transformation Ovary Teratoma |
Issue Date | 1998 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com |
Citation | International Journal Of Gynecological Pathology, 1998, v. 17 n. 4, p. 351-357 How to Cite? |
Abstract | The chromosomal composition of cancers arising in ovarian mature cystic teratoma (MCT) was analyzed using chromosome in situ hybridization (CISH) performed on paraffin-embedded material from 10 squamous cell carcinomas, 1 adenocarcinoma, 1 thyroid papillary carcinoma, and 1 strumal carcinoid. Cervical tissue from seven of these patients was used as a control. In the cancers, a relative gain of chromosome 16 (in 7 cases), chromosome 12 (in 9), chromosome 11 (in 10), and chromosome X (in 8) was detected. Trisomy 12 was diagnosed in eight cases. No chromosomal aberrations were detected in the strumal carcinoid. In the benign areas of the MCTs, only one case showed a gain of chromosome 11, although, in another case, there was a gain of chromosome X. Malignant transformation of MCTs often occurs in association with complex chromosome aberrations that may play a role in the development of such carcinomas. |
Persistent Identifier | http://hdl.handle.net/10722/148103 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.640 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, DH | en_US |
dc.contributor.author | Khoo, US | en_US |
dc.contributor.author | Xue, WC | en_US |
dc.contributor.author | Cheung, ANY | en_US |
dc.date.accessioned | 2012-05-29T06:10:51Z | - |
dc.date.available | 2012-05-29T06:10:51Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | International Journal Of Gynecological Pathology, 1998, v. 17 n. 4, p. 351-357 | en_US |
dc.identifier.issn | 0277-1691 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/148103 | - |
dc.description.abstract | The chromosomal composition of cancers arising in ovarian mature cystic teratoma (MCT) was analyzed using chromosome in situ hybridization (CISH) performed on paraffin-embedded material from 10 squamous cell carcinomas, 1 adenocarcinoma, 1 thyroid papillary carcinoma, and 1 strumal carcinoid. Cervical tissue from seven of these patients was used as a control. In the cancers, a relative gain of chromosome 16 (in 7 cases), chromosome 12 (in 9), chromosome 11 (in 10), and chromosome X (in 8) was detected. Trisomy 12 was diagnosed in eight cases. No chromosomal aberrations were detected in the strumal carcinoid. In the benign areas of the MCTs, only one case showed a gain of chromosome 11, although, in another case, there was a gain of chromosome X. Malignant transformation of MCTs often occurs in association with complex chromosome aberrations that may play a role in the development of such carcinomas. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com | en_US |
dc.relation.ispartof | International Journal of Gynecological Pathology | en_US |
dc.subject | Cytogenetic analysis | - |
dc.subject | Dermoid cyst | - |
dc.subject | Malignant transformation | - |
dc.subject | Ovary | - |
dc.subject | Teratoma | - |
dc.subject.mesh | Adenocarcinoma - Genetics | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Carcinoid Tumor - Genetics | en_US |
dc.subject.mesh | Carcinoma, Papillary - Genetics | en_US |
dc.subject.mesh | Carcinoma, Squamous Cell - Genetics | en_US |
dc.subject.mesh | Cell Transformation, Neoplastic - Genetics | en_US |
dc.subject.mesh | Chromosome Aberrations | en_US |
dc.subject.mesh | Chromosomes, Human, Pair 11 | en_US |
dc.subject.mesh | Chromosomes, Human, Pair 12 | en_US |
dc.subject.mesh | Chromosomes, Human, Pair 16 | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | In Situ Hybridization | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Ovarian Neoplasms - Genetics | en_US |
dc.subject.mesh | Teratoma - Genetics | en_US |
dc.subject.mesh | Thyroid Neoplasms - Genetics | en_US |
dc.subject.mesh | X Chromosome | en_US |
dc.title | Ovarian mature cystic teratoma with malignant transformation: An interphase cytogenetic study | en_US |
dc.type | Article | en_US |
dc.identifier.email | Khoo, US:uskhoo@hkucc.hku.hk | en_US |
dc.identifier.email | Cheung, ANY:anycheun@hkucc.hku.hk | en_US |
dc.identifier.authority | Khoo, US=rp00362 | en_US |
dc.identifier.authority | Cheung, ANY=rp00542 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00004347-199810000-00009 | - |
dc.identifier.pmid | 9785136 | en_US |
dc.identifier.scopus | eid_2-s2.0-0031720088 | en_US |
dc.identifier.hkuros | 34219 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031720088&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 351 | en_US |
dc.identifier.epage | 357 | en_US |
dc.identifier.isi | WOS:000076158600009 | - |
dc.publisher.place | United States | en_US |
dc.identifier.issnl | 0277-1691 | - |