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Conference Paper: SUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b

TitleSUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125b
Authors
Fan, DNYTsang, FHCAu, SLKWei, LLTam, HKAWong, CM
Issue Date2012
PublisherAmerican Association for Cancer Research.
Citation
The 103rd Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. In Cancer Research, 2012, v. 72 n. 8S, abstract no. 1059 How to Cite?
DOI: http://dx.doi.org/10.1158/1538-7445.AM2012-1059
AbstractEpigenetic alternation is a common dysregulated event in hepatocellular carcinoma (HCC) development. Through interrogating the expression of 90 major epigenetic regulating genes, we identified SUV39H1, the prototype histone methyltransferase as one of the most frequently up-regulated epigenetic regulators in human HCC (61%, 23/38). SUV39H1 is responsible for H3K9 trimethylation establishment and essentially involves in heterochromatin formation and transcriptional repression. We found that SUV39H1 up-regulation in human HCC was significantly associated with ...
DescriptionPoster Session 1 - Chromatin Regulators: abstract no. 1059
Persistent Identifierhttp://hdl.handle.net/10722/153102
ISI Accession Number ID
WOS:000209701605054

 

DC FieldValueLanguage
dc.contributor.authorFan, DNYen_US
dc.contributor.authorTsang, FHCen_US
dc.contributor.authorAu, SLKen_US
dc.contributor.authorWei, LLen_US
dc.contributor.authorTam, HKAen_US
dc.contributor.authorWong, CMen_US
dc.date.accessioned2012-07-16T09:56:51Z-
dc.date.available2012-07-16T09:56:51Z-
dc.date.issued2012en_US
dc.identifier.citationThe 103rd Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. In Cancer Research, 2012, v. 72 n. 8S, abstract no. 1059en_US
dc.identifier.urihttp://hdl.handle.net/10722/153102-
dc.descriptionPoster Session 1 - Chromatin Regulators: abstract no. 1059-
dc.description.abstractEpigenetic alternation is a common dysregulated event in hepatocellular carcinoma (HCC) development. Through interrogating the expression of 90 major epigenetic regulating genes, we identified SUV39H1, the prototype histone methyltransferase as one of the most frequently up-regulated epigenetic regulators in human HCC (61%, 23/38). SUV39H1 is responsible for H3K9 trimethylation establishment and essentially involves in heterochromatin formation and transcriptional repression. We found that SUV39H1 up-regulation in human HCC was significantly associated with ...-
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research.-
dc.relation.ispartofCancer Research,en_US
dc.titleSUV39H1 promotes HCC tumorigenesis and is targeted by tumor suppressive miRNA-125ben_US
dc.typeConference_Paperen_US
dc.identifier.emailFan, DNY: dorfan@hku.hken_US
dc.identifier.emailTsang, FHC: h0423902@hku.hken_US
dc.identifier.emailAu, SLK: alkuen@hku.hken_US
dc.identifier.emailWei, LL: larrywei@hku.hken_US
dc.identifier.emailWong, CM: jcmwong@hkucc.hku.hk-
dc.identifier.authorityWong, CM=rp00231en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/1538-7445.AM2012-1059-
dc.identifier.hkuros201255en_US
dc.identifier.volume72-
dc.identifier.issue8S, abstract no. 1059-
dc.identifier.isiWOS:000209701605054-
dc.publisher.placeUnited States-
dc.description.otherThe Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012.-

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