File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/nbm.923
- Scopus: eid_2-s2.0-9244232783
- PMID: 15526349
- WOS: WOS:000225332500007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models
Title | Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models |
---|---|
Authors | |
Keywords | Animal Contrast agent MION Mouse MR imaging Ultrasmall superparamagnetic iron oxide nanoparticle USPIO |
Issue Date | 2004 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087 |
Citation | Nmr In Biomedicine, 2004, v. 17 n. 7, p. 478-483 How to Cite? |
Abstract | Ultrasmall superparamagnetic iron oxide nanoparticles have been widely used during the past decade as MR intravascular contrast agents in the study of animal models. Such agents enhance both T 1 and T 2/T 2* relaxation, although for animal studies it is the later type of enhancement that is most commonly exploited. Their strong microscopic intravascular susceptibility effect enables the local blood volume distribution to be mapped in various organs. High spatial resolution and sensitivity can be achieved, because the long half-life of these agents in blood, combined with anesthetization, permits steady-state measurements over extended periods. This capability has been utilized to study the cerebrovascular blood volume distributions and their changes in normal, activated, pathologic and pharmacologically or genetically modified states, particularly in rodent animal models. It has also been applied to study blood volume changes in other tissues, such as the myocardium. The relaxation rate shifts ΔR 2 and ΔR 2* induced by iron oxide agents may differ depending on certain morphological characteristics of the microvascular network, and sensitive ΔR 2 and ΔR 2* mapping can potentially provide, in addition to blood volume, measurement of other important microvascular parameters such as blood vessel density and size. This work aims to review the applications of ultrasmall superparamagnetic iron oxide contrast agents in MR animal studies, with an emphasis on the investigation of microvascular parameters. Copyright © 2004 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/155773 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, EX | en_US |
dc.contributor.author | Tang, H | en_US |
dc.contributor.author | Jensen, JH | en_US |
dc.date.accessioned | 2012-08-08T08:35:17Z | - |
dc.date.available | 2012-08-08T08:35:17Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Nmr In Biomedicine, 2004, v. 17 n. 7, p. 478-483 | en_US |
dc.identifier.issn | 0952-3480 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/155773 | - |
dc.description.abstract | Ultrasmall superparamagnetic iron oxide nanoparticles have been widely used during the past decade as MR intravascular contrast agents in the study of animal models. Such agents enhance both T 1 and T 2/T 2* relaxation, although for animal studies it is the later type of enhancement that is most commonly exploited. Their strong microscopic intravascular susceptibility effect enables the local blood volume distribution to be mapped in various organs. High spatial resolution and sensitivity can be achieved, because the long half-life of these agents in blood, combined with anesthetization, permits steady-state measurements over extended periods. This capability has been utilized to study the cerebrovascular blood volume distributions and their changes in normal, activated, pathologic and pharmacologically or genetically modified states, particularly in rodent animal models. It has also been applied to study blood volume changes in other tissues, such as the myocardium. The relaxation rate shifts ΔR 2 and ΔR 2* induced by iron oxide agents may differ depending on certain morphological characteristics of the microvascular network, and sensitive ΔR 2 and ΔR 2* mapping can potentially provide, in addition to blood volume, measurement of other important microvascular parameters such as blood vessel density and size. This work aims to review the applications of ultrasmall superparamagnetic iron oxide contrast agents in MR animal studies, with an emphasis on the investigation of microvascular parameters. Copyright © 2004 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/13087 | en_US |
dc.relation.ispartof | NMR in Biomedicine | en_US |
dc.subject | Animal | - |
dc.subject | Contrast agent | - |
dc.subject | MION | - |
dc.subject | Mouse | - |
dc.subject | MR imaging | - |
dc.subject | Ultrasmall superparamagnetic iron oxide nanoparticle | - |
dc.subject | USPIO | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Flow Velocity - Physiology | en_US |
dc.subject.mesh | Contrast Media | en_US |
dc.subject.mesh | Disease Models, Animal | en_US |
dc.subject.mesh | Ferric Compounds - Diagnostic Use | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Image Enhancement - Methods | en_US |
dc.subject.mesh | Magnetic Resonance Imaging - Methods | en_US |
dc.subject.mesh | Microcirculation - Anatomy & Histology - Physiology | en_US |
dc.subject.mesh | Microspheres | en_US |
dc.subject.mesh | Models, Animal | en_US |
dc.subject.mesh | Particle Size | en_US |
dc.title | Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wu, EX:ewu1@hkucc.hku.hk | en_US |
dc.identifier.authority | Wu, EX=rp00193 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/nbm.923 | en_US |
dc.identifier.pmid | 15526349 | - |
dc.identifier.scopus | eid_2-s2.0-9244232783 | en_US |
dc.identifier.hkuros | 109188 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-9244232783&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 478 | en_US |
dc.identifier.epage | 483 | en_US |
dc.identifier.isi | WOS:000225332500007 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_US |
dc.identifier.scopusauthorid | Tang, H=36827331000 | en_US |
dc.identifier.scopusauthorid | Jensen, JH=7404521984 | en_US |
dc.identifier.issnl | 0952-3480 | - |