Resting-state functional connectivity altered by complete and partial corpus callosotomy in rats

Abstract

Resting-state fMRI has been increasingly used in the diagnosis of a variety of brain diseases. However, the underlying mechanism of the spontaneous fluctuations in rsfMRI signals is still under debate. In this study, the effects of complete and partial transection of corpus callosum (CC) on rsfMRI signal were investigated. The loss of interhemispheric functional connections after the complete transection of CC was observed. More importantly, partial CC transection disrupted only the specific intercortical functional connection that is known to be anatomically connected through CC. These findings further indicate that the spontaneous fluctuations in rsfMRI signal largely reflect the anatomical connections.