File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.spinee.2011.02.029
- Scopus: eid_2-s2.0-80051550253
- PMID: 21640659
- WOS: WOS:000293592500001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Natural history of spinal deformity in a patient with Ehlers-Danlos syndrome: case report with 20 year follow-up
Title | Natural history of spinal deformity in a patient with Ehlers-Danlos syndrome: case report with 20 year follow-up |
---|---|
Authors | |
Keywords | Congenital Connective tissue Ehlers-Danlos Scoliosis Spine |
Issue Date | 2011 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/spinee |
Citation | The Spine Journal, 2011, v. 11 n. 7, p. e1-e4 How to Cite? |
Abstract | BACKGROUND CONTEXT: Scoliosis can present in patients with Ehlers-Danlos syndrome (EDS) and can be surgically treated despite possible complications. The long-term natural history of the progression of spinal deformity, particularly scoliosis, and associated complications in EDS patients remains relatively unknown. PURPOSE: To assess the progression of spinal deformity and associated complications in a patient with EDS, who was not surgically treated for her spine condition and was followed up for 20 years. STUDY DESIGN: A case report. METHODS: A 9-year-old female with EDS presented to the orthopedic clinic with scoliosis and mild thoracic hyperkyphosis. The patient was followed up for a 20-year period. Progression of her spinal deformity and associated complications were noted. RESULTS: The patient's curve progressed rapidly in the initial follow-up period an 83 degrees worsening from the age of 9 to 10 years. Because she refused surgical intervention, her spinal deformity continued to progress. As such, by the age of 29 years, she presented with 115 degrees from T9 to L4 with severe hyperkyphosis. The patient eventually developed respiratory compromise and diminished functional capacity. CONCLUSIONS: In patients with EDS, scoliosis may progress rapidly and unrelentingly, and if not treated early may lead to respiratory compromise. Close follow-up of such patients is imperative, and appropriate management should be sought to prevent potentially fatal morbidities. |
Description | Case report |
Persistent Identifier | http://hdl.handle.net/10722/170178 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.804 |
ISI Accession Number ID | |
References | |
Grants |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Natarajan, D | en_US |
dc.contributor.author | Samartzis, D | en_US |
dc.contributor.author | Wong, YW | en_US |
dc.contributor.author | Luk, KDK | en_US |
dc.contributor.author | Cheung, KMC | en_US |
dc.date.accessioned | 2012-10-30T06:05:52Z | - |
dc.date.available | 2012-10-30T06:05:52Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | The Spine Journal, 2011, v. 11 n. 7, p. e1-e4 | en_US |
dc.identifier.issn | 1529-9430 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170178 | - |
dc.description | Case report | - |
dc.description.abstract | BACKGROUND CONTEXT: Scoliosis can present in patients with Ehlers-Danlos syndrome (EDS) and can be surgically treated despite possible complications. The long-term natural history of the progression of spinal deformity, particularly scoliosis, and associated complications in EDS patients remains relatively unknown. PURPOSE: To assess the progression of spinal deformity and associated complications in a patient with EDS, who was not surgically treated for her spine condition and was followed up for 20 years. STUDY DESIGN: A case report. METHODS: A 9-year-old female with EDS presented to the orthopedic clinic with scoliosis and mild thoracic hyperkyphosis. The patient was followed up for a 20-year period. Progression of her spinal deformity and associated complications were noted. RESULTS: The patient's curve progressed rapidly in the initial follow-up period an 83 degrees worsening from the age of 9 to 10 years. Because she refused surgical intervention, her spinal deformity continued to progress. As such, by the age of 29 years, she presented with 115 degrees from T9 to L4 with severe hyperkyphosis. The patient eventually developed respiratory compromise and diminished functional capacity. CONCLUSIONS: In patients with EDS, scoliosis may progress rapidly and unrelentingly, and if not treated early may lead to respiratory compromise. Close follow-up of such patients is imperative, and appropriate management should be sought to prevent potentially fatal morbidities. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/spinee | en_US |
dc.relation.ispartof | The Spine Journal | en_US |
dc.subject | Congenital | - |
dc.subject | Connective tissue | - |
dc.subject | Ehlers-Danlos | - |
dc.subject | Scoliosis | - |
dc.subject | Spine | - |
dc.subject.mesh | Disease Progression | en_US |
dc.subject.mesh | Ehlers-Danlos Syndrome - complications - pathology - radiography | en_US |
dc.subject.mesh | Follow-Up Studies | en_US |
dc.subject.mesh | Kyphosis - etiology - pathology - radiography | en_US |
dc.subject.mesh | Scoliosis - etiology - pathology - radiography | en_US |
dc.title | Natural history of spinal deformity in a patient with Ehlers-Danlos syndrome: case report with 20 year follow-up | en_US |
dc.type | Article | en_US |
dc.identifier.email | Samartzis, D: dspine@hku.hk | en_US |
dc.identifier.email | Wong, YW: yatwa@hkucc.hku.hk | en_US |
dc.identifier.email | Luk, KDK: hcm21000@hku.hk | en_US |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.authority | Samartzis, D=rp01430 | en_US |
dc.identifier.authority | Luk, KDK=rp00333 | en_US |
dc.identifier.authority | Cheung, KMC=rp00387 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.spinee.2011.02.029 | en_US |
dc.identifier.pmid | 21640659 | - |
dc.identifier.scopus | eid_2-s2.0-80051550253 | en_US |
dc.identifier.hkuros | 207319 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80051550253&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | e1 | en_US |
dc.identifier.epage | e4 | en_US |
dc.identifier.isi | WOS:000293592500001 | - |
dc.publisher.place | Netherlands | en_US |
dc.relation.project | Developmental genomics and skeletal research | - |
dc.identifier.scopusauthorid | Cheung, KMC=7402406754 | en_US |
dc.identifier.scopusauthorid | Luk, KDK=7201921573 | en_US |
dc.identifier.scopusauthorid | Wong, YW=36247941700 | en_US |
dc.identifier.scopusauthorid | Samartzis, D=34572771100 | en_US |
dc.identifier.scopusauthorid | Natarajan, D=35334874800 | en_US |
dc.identifier.citeulike | 9496794 | - |
dc.identifier.issnl | 1529-9430 | - |