File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/S1499-3872(12)60159-3
- Scopus: eid_2-s2.0-84861978536
- PMID: 22672820
- WOS: WOS:000305109000006
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Rapid measurement of indocyanine green retention by pulse spectrophotometry: A validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma
Title | Rapid measurement of indocyanine green retention by pulse spectrophotometry: A validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma |
---|---|
Authors | |
Keywords | Child-Pugh A Hepatocellular Carcinoma Indocyanine Green Clearance Limon Liver Cirrhosis Pulse Spectrophotometry |
Issue Date | 2012 |
Publisher | The First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/ |
Citation | Hepatobiliary And Pancreatic Diseases International, 2012, v. 11 n. 3, p. 267-271 How to Cite? |
Abstract | BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly-developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON®, one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73. CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. © 2012, Hepatobiliary Pancreat Dis Int. |
Persistent Identifier | http://hdl.handle.net/10722/173027 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 0.720 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheung, TT | en_US |
dc.contributor.author | Chan, SC | en_US |
dc.contributor.author | Chok, KSH | en_US |
dc.contributor.author | Chan, ACY | en_US |
dc.contributor.author | Yu, WC | en_US |
dc.contributor.author | Poon, RTP | en_US |
dc.contributor.author | Lo, CM | en_US |
dc.contributor.author | Fan, ST | en_US |
dc.date.accessioned | 2012-10-30T06:26:39Z | - |
dc.date.available | 2012-10-30T06:26:39Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Hepatobiliary And Pancreatic Diseases International, 2012, v. 11 n. 3, p. 267-271 | en_US |
dc.identifier.issn | 1499-3872 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173027 | - |
dc.description.abstract | BACKGROUND: The indocyanine green (ICG) retention test is the most popular liver function test for selecting patients for major hepatectomy. Traditionally, it is done using spectrophotometry with serial blood sampling. The newly-developed pulse spectrophotometry is a faster alternative, but its accuracy on Child-Pugh A cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma has not been well documented. This study aimed to assess the accuracy of the LiMON®, one of the pulse spectrophotometry systems, in measuring preoperative ICG retention in these patients and to devise an easy formula for conversion of the results so that they can be compared with classical literature records where ICG retention was measured by the traditional method. METHODS: We measured the liver function of 70 Child-Pugh A cirrhotic patients before hepatectomy for hepatocellular carcinoma from September 2008 to January 2009. ICG retention at 15 minutes measured by traditional spectrophotometry (ICGR15) was compared with ICG retention at 15 minutes measured by the LiMON (ICGR15(L)). RESULTS: The median ICGR15 was 14.7% (5.6%-32%) and the median ICGR15(L) was 10.4% (1.2%-28%). The mean difference between them was -4.3606. There was a strong correlation between ICGR15 and ICGR15(L) (correlation coefficient, 0.844; 95% confidence interval, 0.762-0.899). The following formula was devised: ICGR15=1.16×ICGR15(L)+2.73. CONCLUSIONS: The LiMON provides a fast and repeatable way to measure ICG retention at 15 minutes, but with constant underestimation of the real value. Therefore, when comparing results obtained by traditional spectrophotometry and the LiMON, adjustment of results from the latter is necessary, and this can be done with a simple mathematical calculation using the above formula. © 2012, Hepatobiliary Pancreat Dis Int. | en_US |
dc.language | eng | en_US |
dc.publisher | The First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/ | en_US |
dc.relation.ispartof | Hepatobiliary and Pancreatic Diseases International | en_US |
dc.subject | Child-Pugh A | en_US |
dc.subject | Hepatocellular Carcinoma | en_US |
dc.subject | Indocyanine Green Clearance | en_US |
dc.subject | Limon | en_US |
dc.subject | Liver Cirrhosis | en_US |
dc.subject | Pulse Spectrophotometry | en_US |
dc.title | Rapid measurement of indocyanine green retention by pulse spectrophotometry: A validation study in 70 patients with Child-Pugh A cirrhosis before hepatectomy for hepatocellular carcinoma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, SC: chanlsc@hkucc.hku.hk | en_US |
dc.identifier.email | Chan, ACY: acchan@hku.hk | en_US |
dc.identifier.email | Poon, RTP: poontp@hkucc.hku.hk | en_US |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_US |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | - |
dc.identifier.email | Yu, WC: yuwc@hku.hk | - |
dc.identifier.email | Fan, ST: stfan@hku.hk | - |
dc.identifier.authority | Chan, SC=rp01568 | en_US |
dc.identifier.authority | Chan, ACY=rp00310 | en_US |
dc.identifier.authority | Poon, RTP=rp00446 | en_US |
dc.identifier.authority | Lo, CM=rp00412 | en_US |
dc.identifier.authority | Fan, ST=rp00355 | - |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1016/S1499-3872(12)60159-3 | en_US |
dc.identifier.pmid | 22672820 | - |
dc.identifier.scopus | eid_2-s2.0-84861978536 | en_US |
dc.identifier.hkuros | 211060 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84861978536&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 267 | en_US |
dc.identifier.epage | 271 | en_US |
dc.identifier.isi | WOS:000305109000006 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Cheung, TT=7103334165 | en_US |
dc.identifier.scopusauthorid | Chan, SC=7404255575 | en_US |
dc.identifier.scopusauthorid | Chok, KSH=6508229426 | en_US |
dc.identifier.scopusauthorid | Chan, ACY=15828849100 | en_US |
dc.identifier.scopusauthorid | Yu, WC=55216510100 | en_US |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_US |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_US |
dc.identifier.scopusauthorid | Fan, ST=55245914000 | en_US |
dc.identifier.issnl | 2352-9377 | - |