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- Publisher Website: 10.1111/j.1477-2574.2012.00491.x
- Scopus: eid_2-s2.0-84865126884
- PMID: 22882199
- WOS: WOS:000307500300008
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Article: Effects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosis
Title | Effects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosis |
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Authors | |
Keywords | Body Mass Index Donor Hepatectomy Fatty Change Liver Transplantation Living Donor Steatotic Donor |
Issue Date | 2012 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1365182X.asp |
Citation | Hpb, 2012, v. 14 n. 9, p. 619-624 How to Cite? |
Abstract | Background: Hepatic steatosis is a major concern in living donor liver transplantation. Factors affecting hepatic functional status after a donor right hepatectomy (with the middle hepatic vein included in the graft) with a focus on changes owing to steatosis were retrospectively studied. Methods: Donors (n= 325) were categorized into three groups: G0 (no steatosis, n= 178), G1 (< = 10% steatosis, n= 128) and G2 (>10% steatosis, n= 19). Donors with >20% steatosis were excluded. Changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin levels and prothrombin time (PT) were assessed. Factors predicting steatosis were also assessed. A liver biopsy was performed on selected donors. Results: The ALT level rose until day 3 in G1 and day 6 in G2 (P < 0.05). The AST level rose until day 7 in G2 (P < 0.05) but stayed unchanged in G1. The bilirubin level was higher only on day 1 in G2 (P < 0.05). By day 30, no significant difference between any groups was noted. Receiver-operating characteristic (ROC) area under the curve for body mass index (BMI) on predicting steatosis was 0.75 [confidence interval (CI) = 69-80]. Among donors with a BMI > 23.5 kg/m 2, 75% had steatosis. Five donors had >20% steatosis and were not assessed. Conclusion: Using a liver with up to 20% steatosis in right liver donation, even if the middle hepatic vein is included in the graft, is safe. For Asian donors, a BMI > 23.5 kg/m 2 is a guide in deciding whether to perform a liver biopsy for steatosis. © 2012 International Hepato-Pancreato-Biliary Association. |
Persistent Identifier | http://hdl.handle.net/10722/173042 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.141 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Siriwardana, RC | en_US |
dc.contributor.author | Chan, SC | en_US |
dc.contributor.author | Chok, KSH | en_US |
dc.contributor.author | Lo, CM | en_US |
dc.contributor.author | Fan, ST | en_US |
dc.date.accessioned | 2012-10-30T06:26:56Z | - |
dc.date.available | 2012-10-30T06:26:56Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Hpb, 2012, v. 14 n. 9, p. 619-624 | en_US |
dc.identifier.issn | 1365-182X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/173042 | - |
dc.description.abstract | Background: Hepatic steatosis is a major concern in living donor liver transplantation. Factors affecting hepatic functional status after a donor right hepatectomy (with the middle hepatic vein included in the graft) with a focus on changes owing to steatosis were retrospectively studied. Methods: Donors (n= 325) were categorized into three groups: G0 (no steatosis, n= 178), G1 (< = 10% steatosis, n= 128) and G2 (>10% steatosis, n= 19). Donors with >20% steatosis were excluded. Changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin levels and prothrombin time (PT) were assessed. Factors predicting steatosis were also assessed. A liver biopsy was performed on selected donors. Results: The ALT level rose until day 3 in G1 and day 6 in G2 (P < 0.05). The AST level rose until day 7 in G2 (P < 0.05) but stayed unchanged in G1. The bilirubin level was higher only on day 1 in G2 (P < 0.05). By day 30, no significant difference between any groups was noted. Receiver-operating characteristic (ROC) area under the curve for body mass index (BMI) on predicting steatosis was 0.75 [confidence interval (CI) = 69-80]. Among donors with a BMI > 23.5 kg/m 2, 75% had steatosis. Five donors had >20% steatosis and were not assessed. Conclusion: Using a liver with up to 20% steatosis in right liver donation, even if the middle hepatic vein is included in the graft, is safe. For Asian donors, a BMI > 23.5 kg/m 2 is a guide in deciding whether to perform a liver biopsy for steatosis. © 2012 International Hepato-Pancreato-Biliary Association. | en_US |
dc.language | eng | en_US |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1365182X.asp | en_US |
dc.relation.ispartof | HPB | en_US |
dc.subject | Body Mass Index | en_US |
dc.subject | Donor Hepatectomy | en_US |
dc.subject | Fatty Change | en_US |
dc.subject | Liver Transplantation | en_US |
dc.subject | Living Donor | en_US |
dc.subject | Steatotic Donor | en_US |
dc.title | Effects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_US |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_US |
dc.identifier.email | Siriwardana, RC: rohan@hku.hk | - |
dc.identifier.email | Chan, SC: chanlsc@hkucc.hku.hk | - |
dc.identifier.authority | Lo, CM=rp00412 | en_US |
dc.identifier.authority | Fan, ST=rp00355 | en_US |
dc.identifier.authority | Chan, SC=rp01568 | - |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1477-2574.2012.00491.x | en_US |
dc.identifier.pmid | 22882199 | - |
dc.identifier.scopus | eid_2-s2.0-84865126884 | en_US |
dc.identifier.hkuros | 211017 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84865126884&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.spage | 619 | en_US |
dc.identifier.epage | 624 | en_US |
dc.identifier.isi | WOS:000307500300008 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Siriwardana, RC=35321203400 | en_US |
dc.identifier.scopusauthorid | Chan, SC=36901164300 | en_US |
dc.identifier.scopusauthorid | Chok, KSH=6508229426 | en_US |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_US |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_US |
dc.identifier.issnl | 1365-182X | - |