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Patent History
- ApplicationEP 20060704231 2006-02-01
- PublicationEP 1846004 2007-10-24
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published patent: NEW USES OF DINUCLEOTIDE POLYPHOSPHATE DERIVATIVES
Title | NEW USES OF DINUCLEOTIDE POLYPHOSPHATE DERIVATIVES |
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Priority Date | 2006-02-01 PCT/GB2006000343 2005-02-03 GB20050002250 |
Inventors | |
Issue Date | 2007 |
Citation | EP Published Patent application EP 1846004. European Patent Office (EPO), Escapenet, 2007 How to Cite? |
Abstract | The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X<1> and X<2> are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX<3>X<4>-,-NH-,-O- ; wherein X<3> and X<4 >are selected from H, CI, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1 , 2, 3, 4 and 5; W is selected from 0, 1 , 2, 3, 4 and 5; and V plus W is an integer from 2 to 6. |
Persistent Identifier | http://hdl.handle.net/10722/176750 |
References |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:38:26Z | - |
dc.date.available | 2012-11-30T08:38:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | EP Published Patent application EP 1846004. European Patent Office (EPO), Escapenet, 2007 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/176750 | - |
dc.description.abstract | The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X<1> and X<2> are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX<3>X<4>-,-NH-,-O- ; wherein X<3> and X<4 >are selected from H, CI, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1 , 2, 3, 4 and 5; W is selected from 0, 1 , 2, 3, 4 and 5; and V plus W is an integer from 2 to 6. | en_HK |
dc.title | NEW USES OF DINUCLEOTIDE POLYPHOSPHATE DERIVATIVES | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | Miller, Andrew David | en_HK |
dc.contributor.inventor | Wright, Michael | en_HK |
dc.contributor.inventor | Lozovaya, Natalya | en_HK |
dc.contributor.inventor | Tanner, JA | en_HK |
patents.identifier.application | EP 20060704231 | en_HK |
patents.description.assignee | IMUTHES LTD [GB] | en_HK |
patents.description.country | European Patent Office | en_HK |
patents.date.publication | 2007-10-24 | en_HK |
dc.relation.references | WO 03000056 (A1) 2003-01-03 | en_HK |
dc.relation.references | WO 03039473 (A3) 2003-10-23 | en_HK |
dc.relation.references | WO 03039473 (A2) 2003-05-15 | en_HK |
dc.relation.references | US 2003125299 (A1) 2003-07-03 | en_HK |
dc.relation.references | US 7256183 (B2) 2007-08-14 | en_HK |
dc.relation.references | US 2002103158 (A1) 2002-08-01 | en_HK |
dc.relation.references | US 6555675 (B2) 2003-04-29 | en_HK |
dc.relation.references | US 2002193340 (A1) 2002-12-19 | en_HK |
dc.relation.references | US 6696425 (B2) 2004-02-24 | en_HK |
dc.relation.references | WO 9903480 (A1) 1999-01-28 | en_HK |
dc.relation.references | WO 9855494 (A1) 1998-12-10 | en_HK |
dc.relation.references | US 5837861 (A) 1998-11-17 | en_HK |
dc.relation.references | WO 9834942 (A3) 2000-01-06 | en_HK |
dc.relation.references | WO 9834942 (A2) 1998-08-13 | en_HK |
dc.relation.references | XP 009067425 | en_HK |
patents.date.application | 2006-02-01 | en_HK |
patents.date.priority | 2006-02-01 PCT/GB2006000343 | en_HK |
patents.date.priority | 2005-02-03 GB20050002250 | en_HK |
patents.description.cc | EP | en_HK |
patents.identifier.publication | EP 1846004 | en_HK |
patents.relation.family | AU 2006210715 (A1) 2006-08-10 | en_HK |
patents.relation.family | CA 2596959 (A1) 2006-08-10 | en_HK |
patents.relation.family | CN 101180066 (A) 2008-05-14 | en_HK |
patents.relation.family | EP 1846004 (A1) 2007-10-24 | en_HK |
patents.relation.family | JP 2008528665 (A) 2008-07-31 | en_HK |
patents.relation.family | US 2008319184 (A1) 2008-12-25 | en_HK |
patents.relation.family | WO 2006082397 (A1) 2006-08-10 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |