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Patent History
- ApplicationUS 10/841125 2004-05-07
- PublicationUS 2005079618 2005-04-14
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published patent: Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids
Title | Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids |
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Priority Date | 2004-05-07 US 10/841125 2003-05-09 PCT/US2003014657 2003-05-09 US 10/469494P |
Inventors | |
Issue Date | 2005 |
Citation | US Published patent application US 2005079618. Washington, DC: US Patent and Trademark Office (USPTO), 2005 How to Cite? |
Abstract | Methods are disclosed herein for inducing homologous recombination in a host cell comprising a target nucleic acid, using a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule has a sufficient number of nucleotides homologous to the target nucleic acid to enable homologous recombination with the target nucleic acid. The host cell includes a de-repressible promoter operably linked to a nucleic acid encoding a single-stranded binding protein and is deficient for mismatch repair. Isolated host cells of use in this method are also disclosed. |
Persistent Identifier | http://hdl.handle.net/10722/176891 |
DC Field | Value | Language |
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dc.date.accessioned | 2012-11-30T08:38:40Z | - |
dc.date.available | 2012-11-30T08:38:40Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | US Published patent application US 2005079618. Washington, DC: US Patent and Trademark Office (USPTO), 2005 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/176891 | - |
dc.description.abstract | Methods are disclosed herein for inducing homologous recombination in a host cell comprising a target nucleic acid, using a single-stranded nucleic acid molecule. The single-stranded nucleic acid molecule has a sufficient number of nucleotides homologous to the target nucleic acid to enable homologous recombination with the target nucleic acid. The host cell includes a de-repressible promoter operably linked to a nucleic acid encoding a single-stranded binding protein and is deficient for mismatch repair. Isolated host cells of use in this method are also disclosed. | en_HK |
dc.relation.isreferencedby | US 7674621 (B2) 2010-03-09 | en_HK |
dc.relation.isreferencedby | US 2005273869 (A1) 2005-12-08 | en_HK |
dc.title | Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids | en_HK |
dc.type | Patent | en_US |
dc.description.nature | published_or_final_version | en_US |
dc.contributor.inventor | Court Donald L | en_HK |
dc.contributor.inventor | Li Xin-Tian | en_HK |
dc.contributor.inventor | Huang, J | en_HK |
dc.contributor.inventor | Costantino Nina | en_HK |
dc.contributor.inventor | Liu Depei | en_HK |
patents.identifier.application | US 10/841125 | en_HK |
patents.description.assignee | US GOV HEALTH & HUMAN SERV [US] | en_HK |
patents.description.country | United States of America | en_HK |
patents.date.publication | 2005-04-14 | en_HK |
patents.date.application | 2004-05-07 | en_HK |
patents.date.priority | 2004-05-07 US 10/841125 | en_HK |
patents.date.priority | 2003-05-09 PCT/US2003014657 | en_HK |
patents.date.priority | 2003-05-09 US 10/469494P | en_HK |
patents.description.cc | US | en_HK |
patents.identifier.publication | US 2005079618 | en_HK |
patents.relation.family | AU 2003228972 (A1) 2005-01-21 | en_HK |
patents.relation.family | US 2005079618 (A1) 2005-04-14 | en_HK |
patents.relation.family | US 7521242 (B2) 2009-04-21 | en_HK |
patents.relation.family | WO 2004106513 (A1) 2004-12-09 | en_HK |
patents.description.kind | A1 | en_HK |
patents.type | Patent_published | en_HK |