published patent: High-Throughput Diagnostic Assay For the Human Virus Causing Severe Acute Respiratory Syndrome (SARS)

TitleHigh-Throughput Diagnostic Assay For the Human Virus Causing Severe Acute Respiratory Syndrome (SARS)
Priority Date2009-06-12 US 12/483301
2004-03-24 US 10/807807
2003-03-24 US 10/457031P
2003-03-26 US 10/457730P
2003-04-02 US 10/459931P
2003-04-03 US 10/460357P
2003-04-08 US 10/461265P
2003-04-14 US 10/462805P
2003-04-23 US 10/464886P
2003-04-25 US 10/465738P
2003-05-14 US 10/470935P
Inventors
Issue Date2010
Citation
US Published patent application US 2010285457. Washington, DC: US Patent and Trademark Office (USPTO), 2010 How to Cite?
AbstractThe present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ("hSARS virus"). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.
Persistent Identifierhttp://hdl.handle.net/10722/177002

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:55Z-
dc.date.available2012-11-30T08:38:55Z-
dc.date.issued2010-
dc.identifier.citationUS Published patent application US 2010285457. Washington, DC: US Patent and Trademark Office (USPTO), 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177002-
dc.description.abstractThe present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans ("hSARS virus"). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be used for diagnosis and monitoring the spread of SARS and is based on the nucleotide sequences of the N (nucleocapsid)-gene of the hSARS virus. The present method eliminates false negative results and provides increased sensitivity for the assay. The invention also discloses the S (spike)-gene of the hSARS virus. The invention further relates to the deduced amino acid sequences of the N-gene and S-gene products of the hSARS virus and to the use of the N-gene and S-gene products in diagnostic methods. The invention further encompasses diagnostic assays and kits comprising antibodies generated against the N-gene or S-gene product.en_HK
dc.titleHigh-Throughput Diagnostic Assay For the Human Virus Causing Severe Acute Respiratory Syndrome (SARS)en_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorPeiris, JSMen_HK
dc.contributor.inventorYuen, KYen_HK
dc.contributor.inventorPoon, LLMen_HK
dc.contributor.inventorGuan, Yen_HK
dc.contributor.inventorChan Kwok Hungen_HK
dc.contributor.inventorNicholls, JMen_HK
dc.contributor.inventorLeung, FCCen_HK
patents.identifier.applicationUS 12/483301en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2010-11-11en_HK
patents.date.application2009-06-12en_HK
patents.date.priority2009-06-12 US 12/483301en_HK
patents.date.priority2004-03-24 US 10/807807en_HK
patents.date.priority2003-03-24 US 10/457031Pen_HK
patents.date.priority2003-03-26 US 10/457730Pen_HK
patents.date.priority2003-04-02 US 10/459931Pen_HK
patents.date.priority2003-04-03 US 10/460357Pen_HK
patents.date.priority2003-04-08 US 10/461265Pen_HK
patents.date.priority2003-04-14 US 10/462805Pen_HK
patents.date.priority2003-04-23 US 10/464886Pen_HK
patents.date.priority2003-04-25 US 10/465738Pen_HK
patents.date.priority2003-05-14 US 10/470935Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2010285457en_HK
patents.relation.familyCN 1761745 (A) 2006-04-19en_HK
patents.relation.familyCN 100543132 (C) 2009-09-23en_HK
patents.relation.familyCN 1768074 (A) 2006-05-03en_HK
patents.relation.familyCN 1768140 (A) 2006-05-03en_HK
patents.relation.familyCN 101186920 (A) 2008-05-28en_HK
patents.relation.familyCN 102021147 (A) 2011-04-20en_HK
patents.relation.familyUS 2005009009 (A1) 2005-01-13en_HK
patents.relation.familyUS 7267942 (B2) 2007-09-11en_HK
patents.relation.familyUS 2008069838 (A1) 2008-03-20en_HK
patents.relation.familyUS 7375202 (B2) 2008-05-20en_HK
patents.relation.familyUS 2005181357 (A1) 2005-08-18en_HK
patents.relation.familyUS 7547512 (B2) 2009-06-16en_HK
patents.relation.familyUS 2010080824 (A1) 2010-04-01en_HK
patents.relation.familyUS 7785775 (B2) 2010-08-31en_HK
patents.relation.familyUS 2010184019 (A1) 2010-07-22en_HK
patents.relation.familyUS 2010285457 (A1) 2010-11-11en_HK
patents.relation.familyWO 2004085455 (A1) 2004-10-07en_HK
patents.relation.familyWO 2004085633 (A1) 2004-10-07en_HK
patents.relation.familyWO 2004085650 (A1) 2004-10-07en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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