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Article: Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation

TitleComparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation
Authors
KeywordsGraves' ophthalmopathy
Intensity-modulated radiation therapy
Retro-orbital irradiation
Issue Date2012
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.ro-journal.com
Citation
Radiation Oncology, 2012, v. 7, article no. 199 How to Cite?
AbstractBackground: We would like to investigate the if IMRT produced better target coverage and dose sparing to adjacent normal structures as compared with 3-dimensional conformal radiotherapy (3DCRT) and lateral opposing fields (LOF) for patients with Graves’ ophthalmopathy treated with retro-orbital irradiation. Methods: Ten consecutive patients diagnosed with Graves’ ophthalmopathy were prospectively recruited into this study. An individual IMRT, 3DCRT and LOF plan was created for each patient. Conformity index (CI), homogeneity index (HI) and other dosimetric parameters of the targets and organs-at-risk (OAR) generated by IMRT were compared with the other two techniques. Results: Mann–Whitney U test demonstrated that CI generated by IMRT was superior to that produced by 3DCRT and LOF (p=0.005 for both respectively). Similarly HI with IMRT was proven better than 3DCRT (p=0.007) and LOF (p=0.005). IMRT gave rise to better dose sparing to some OARs including globes, lenses and optic nerves as compared with 3DCRT but not with LOF. Conclusions: IMRT, as compared with 3DCRT and LOF, was found to have a better target coverage, conformity and homogeneity and dose sparing to some surrounding structures, despite a slight increase but clinically negligible dose to other structures. Dosimetrically it might be a preferred treatment technique and a longer follow up is warranted to establish its role in routine clinical use.
Persistent Identifierhttp://hdl.handle.net/10722/183709
ISSN
2018 Impact Factor: 2.895
2015 SCImago Journal Rankings: 1.278
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, VHFen_US
dc.contributor.authorNg, CYen_US
dc.contributor.authorChoi, CWen_US
dc.contributor.authorLuk, MYen_US
dc.contributor.authorLeung, TWen_US
dc.contributor.authorAu, GKHen_US
dc.contributor.authorKwong, DLWen_US
dc.date.accessioned2013-06-18T04:09:22Z-
dc.date.available2013-06-18T04:09:22Z-
dc.date.issued2012en_US
dc.identifier.citationRadiation Oncology, 2012, v. 7, article no. 199en_US
dc.identifier.issn1748-717X-
dc.identifier.urihttp://hdl.handle.net/10722/183709-
dc.description.abstractBackground: We would like to investigate the if IMRT produced better target coverage and dose sparing to adjacent normal structures as compared with 3-dimensional conformal radiotherapy (3DCRT) and lateral opposing fields (LOF) for patients with Graves’ ophthalmopathy treated with retro-orbital irradiation. Methods: Ten consecutive patients diagnosed with Graves’ ophthalmopathy were prospectively recruited into this study. An individual IMRT, 3DCRT and LOF plan was created for each patient. Conformity index (CI), homogeneity index (HI) and other dosimetric parameters of the targets and organs-at-risk (OAR) generated by IMRT were compared with the other two techniques. Results: Mann–Whitney U test demonstrated that CI generated by IMRT was superior to that produced by 3DCRT and LOF (p=0.005 for both respectively). Similarly HI with IMRT was proven better than 3DCRT (p=0.007) and LOF (p=0.005). IMRT gave rise to better dose sparing to some OARs including globes, lenses and optic nerves as compared with 3DCRT but not with LOF. Conclusions: IMRT, as compared with 3DCRT and LOF, was found to have a better target coverage, conformity and homogeneity and dose sparing to some surrounding structures, despite a slight increase but clinically negligible dose to other structures. Dosimetrically it might be a preferred treatment technique and a longer follow up is warranted to establish its role in routine clinical use.-
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.ro-journal.com-
dc.relation.ispartofRadiation Oncologyen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectGraves' ophthalmopathy-
dc.subjectIntensity-modulated radiation therapy-
dc.subjectRetro-orbital irradiation-
dc.titleComparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiationen_US
dc.typeArticleen_US
dc.identifier.emailLee, VHF: vhflee@hku.hken_US
dc.identifier.emailNg, CY: ngchoryi@hku.hken_US
dc.identifier.emailChoi, CW: hcchoi@hku.hken_US
dc.identifier.emailLuk, MY: myluk@hkucc.hku.hken_US
dc.identifier.emailLeung, TW: ltw920@hkucc.hku.hken_US
dc.identifier.emailAu, GKH: hkugkhau@hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_US
dc.identifier.authorityLee, VHF=rp00264en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1748-717X-7-199-
dc.identifier.pmid23181900-
dc.identifier.pmcidPMC3573990-
dc.identifier.scopuseid_2-s2.0-84869875624-
dc.identifier.hkuros214647en_US
dc.identifier.hkuros239721-
dc.identifier.volume7en_US
dc.identifier.spagearticle no. 199-
dc.identifier.epagearticle no. 199-
dc.identifier.isiWOS:000315406700001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1748-717X-

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