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Conference Paper: Dissecting the gender disparity of hepatocellular carcinoma: roles of HBV X protein and androgen receptor
| Title | Dissecting the gender disparity of hepatocellular carcinoma: roles of HBV X protein and androgen receptor |
|---|---|
| Authors | |
| Keywords | Medical sciences Oncology |
| Issue Date | 2013 |
| Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
| Citation | The 104th Annual Meeting of the American Association for Cancer Research (AACR 2013), Washington, DC., 6-10 April 2013. In Cancer Research, 2013, v. 73 n. 8 suppl. 1, abstract no. 4778 How to Cite? |
| Abstract | Hepatocellular carcinoma (HCC) is a leading cancer worldwide and especially prevalent in Southeast Asia, due to prevalent hepatitis B virus (HBV) infection. HBV-associated HCC has a male predominance, with a male-to-female ratio of about 4-5:1. HBV is a partially double-stranded DNA virus containing four overlapping open reading frames. Among them, X gene is most frequently integrated into host genome naturally and plays an important role in hepatocarcinogenesis. In male HBV carriers, the risk of HCC development is significantly increased in those with higher serum androgen and androgen receptor (AR) activity. HBV infection may, therefore, particularly cooperate with male-specific AR signalling to accelerate hepatocarcinogenesis. In this study, we ... |
| Description | Conference Theme: Personalizing Cancer Care Through Discovery Science Poster Session 7 - Transformation and Promotion: abstract no. 4778 This journal suppl. entitled: Proceedings: AACR 104th Annual Meeting ... 2013 |
| Persistent Identifier | http://hdl.handle.net/10722/186892 |
| ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chiu, YT | en_US |
| dc.contributor.author | Ng, IOL | - |
| dc.date.accessioned | 2013-08-20T12:23:36Z | - |
| dc.date.available | 2013-08-20T12:23:36Z | - |
| dc.date.issued | 2013 | en_US |
| dc.identifier.citation | The 104th Annual Meeting of the American Association for Cancer Research (AACR 2013), Washington, DC., 6-10 April 2013. In Cancer Research, 2013, v. 73 n. 8 suppl. 1, abstract no. 4778 | en_US |
| dc.identifier.issn | 0008-5472 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/186892 | - |
| dc.description | Conference Theme: Personalizing Cancer Care Through Discovery Science | - |
| dc.description | Poster Session 7 - Transformation and Promotion: abstract no. 4778 | - |
| dc.description | This journal suppl. entitled: Proceedings: AACR 104th Annual Meeting ... 2013 | - |
| dc.description.abstract | Hepatocellular carcinoma (HCC) is a leading cancer worldwide and especially prevalent in Southeast Asia, due to prevalent hepatitis B virus (HBV) infection. HBV-associated HCC has a male predominance, with a male-to-female ratio of about 4-5:1. HBV is a partially double-stranded DNA virus containing four overlapping open reading frames. Among them, X gene is most frequently integrated into host genome naturally and plays an important role in hepatocarcinogenesis. In male HBV carriers, the risk of HCC development is significantly increased in those with higher serum androgen and androgen receptor (AR) activity. HBV infection may, therefore, particularly cooperate with male-specific AR signalling to accelerate hepatocarcinogenesis. In this study, we ... | - |
| dc.language | eng | en_US |
| dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
| dc.relation.ispartof | Cancer Research | en_US |
| dc.subject | Medical sciences | - |
| dc.subject | Oncology | - |
| dc.title | Dissecting the gender disparity of hepatocellular carcinoma: roles of HBV X protein and androgen receptor | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Chiu, YT: eytchiu@hku.hk | en_US |
| dc.identifier.email | Ng, IOL: iolng@hku.hk | - |
| dc.description.nature | link_to_OA_fulltext | - |
| dc.identifier.doi | 10.1158/1538-7445.AM2013-4778 | - |
| dc.identifier.hkuros | 218413 | en_US |
| dc.identifier.volume | 73 | - |
| dc.identifier.issue | 8 suppl. 1 | - |
| dc.identifier.isi | WOS:000331220604341 | - |
| dc.publisher.place | United States | - |
| dc.identifier.issnl | 0008-5472 | - |