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- Publisher Website: 10.1109/EMBC.2012.6346417
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- PMID: 23366378
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Conference Paper: In vivo manganese-enhanced MRI for visuotopic brain mapping
Title | In vivo manganese-enhanced MRI for visuotopic brain mapping |
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Authors | |
Keywords | Visual Perception - physiology |
Issue Date | 2012 |
Publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 |
Citation | The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 2279-2282 How to Cite? |
Abstract | This study explored the feasibility of localized manganese-enhanced MRI (MEMRI) via 3 different routes of Mn(2+) administrations for visuotopic brain mapping of retinal, callosal, cortico-subcortical, transsynaptic and horizontal connections in normal adult rats. Upon fractionated intravitreal Mn(2+) injection, Mn enhancements were observed in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn(2+) injection and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn(2+) injection. Direct, single-dose Mn(2+) injection to the LGN resulted in Mn enhancement by 13-21% in V1 and 8-11% in SC of the ipsilateral hemisphere at 8 to 24 hours after Mn(2+) administration. Intracortical, single-dose Mn(2+) injection to the visual cortex resulted in Mn enhancement by 53-65% in ipsilateral LGN, 15-26% in ipsilateral SC, 32-34% in the splenium of corpus callosum and 17-25% in contralateral V1/V2 transition zone at 8 to 24 hours after Mn(2+) administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Laminar-specific horizontal cortical connections were also observed in the ipsilateral hemisphere. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components and connections in the visual system longitudinally during development, plasticity, pharmacological interventions and genetic modifications. |
Persistent Identifier | http://hdl.handle.net/10722/191623 |
ISBN | |
ISSN | 2020 SCImago Journal Rankings: 0.282 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, KC | en_US |
dc.contributor.author | Wu, EX | en_US |
dc.date.accessioned | 2013-10-15T07:14:43Z | - |
dc.date.available | 2013-10-15T07:14:43Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2012), San Diego, CA., 28 August-1 September 2012. In IEEE Engineering in Medicine and Biology Society Conference Proceedings, 2012, p. 2279-2282 | en_US |
dc.identifier.isbn | 978-1-4577-1787-1 | - |
dc.identifier.issn | 1557-170X | - |
dc.identifier.uri | http://hdl.handle.net/10722/191623 | - |
dc.description.abstract | This study explored the feasibility of localized manganese-enhanced MRI (MEMRI) via 3 different routes of Mn(2+) administrations for visuotopic brain mapping of retinal, callosal, cortico-subcortical, transsynaptic and horizontal connections in normal adult rats. Upon fractionated intravitreal Mn(2+) injection, Mn enhancements were observed in the contralateral superior colliculus (SC) and lateral geniculate nucleus (LGN) by 45-60% at 1-3 days after initial Mn(2+) injection and in the contralateral primary visual cortex (V1) by about 10% at 2-3 days after initial Mn(2+) injection. Direct, single-dose Mn(2+) injection to the LGN resulted in Mn enhancement by 13-21% in V1 and 8-11% in SC of the ipsilateral hemisphere at 8 to 24 hours after Mn(2+) administration. Intracortical, single-dose Mn(2+) injection to the visual cortex resulted in Mn enhancement by 53-65% in ipsilateral LGN, 15-26% in ipsilateral SC, 32-34% in the splenium of corpus callosum and 17-25% in contralateral V1/V2 transition zone at 8 to 24 hours after Mn(2+) administration. Notably, some patchy patterns were apparent near the V1/V2 border of the contralateral hemisphere. Laminar-specific horizontal cortical connections were also observed in the ipsilateral hemisphere. The current results demonstrated the sensitivity of MEMRI for assessing the neuroarchitecture of the visual brains in vivo without depth-limitation, and may possess great potentials for studying the basic neural components and connections in the visual system longitudinally during development, plasticity, pharmacological interventions and genetic modifications. | - |
dc.language | eng | en_US |
dc.publisher | Institute of Electrical and Electronics Engineers. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 | - |
dc.relation.ispartof | IEEE Engineering in Medicine and Biology Society Conference Proceedings | en_US |
dc.subject | Visual Perception - physiology | - |
dc.subject.mesh | Brain Mapping - methods | - |
dc.subject.mesh | Evoked Potentials, Visual - physiology | - |
dc.subject.mesh | Image Enhancement - methods | - |
dc.subject.mesh | Magnetic Resonance Imaging - methods | - |
dc.subject.mesh | Manganese - diagnostic use | - |
dc.subject.mesh | Nerve Net - physiology | - |
dc.title | In vivo manganese-enhanced MRI for visuotopic brain mapping | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | en_US |
dc.identifier.authority | Wu, EX=rp00193 | en_US |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1109/EMBC.2012.6346417 | - |
dc.identifier.pmid | 23366378 | - |
dc.identifier.scopus | eid_2-s2.0-84880946317 | - |
dc.identifier.hkuros | 225949 | en_US |
dc.identifier.spage | 2279 | - |
dc.identifier.epage | 2282 | - |
dc.publisher.place | United States | en_US |
dc.customcontrol.immutable | sml 131107 | - |
dc.identifier.issnl | 1557-170X | - |