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Conference Paper: Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis
Title | Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis |
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Authors | |
Keywords | Medical sciences Oncology |
Issue Date | 2014 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | The 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. 1565 How to Cite? |
Abstract | Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ... |
Description | Molecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565 This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ... |
Persistent Identifier | http://hdl.handle.net/10722/197695 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ko, FCF | - |
dc.contributor.author | Yeung, YS | - |
dc.contributor.author | Mao, X | - |
dc.contributor.author | Yam, JWP | - |
dc.date.accessioned | 2014-05-29T08:42:46Z | - |
dc.date.available | 2014-05-29T08:42:46Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. 1565 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/197695 | - |
dc.description | Molecular and Cellular Biology - Poster Presentations - Proffered Abstracts - Poster Presentations - Tumor Suppressors 2: abstract no. 1565 | - |
dc.description | This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014 ... | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene critically involved in hepatocarcinogenesis. DLC1 is a Rho GTPase activating protein (RhoGAP), which serves as the negative regulator of Rho proteins. Rho proteins are important in remodeling of actin cytoskeleton, transcription regulation, cell proliferation, tumorigenesis and metastasis. Apart from RhoGAP activity, the inhibitory activity of DLC1 is also dependent on its proper focal adhesion localization. It has been found that tensin proteins are responsible for directing DLC1 to the focal adhesions via their interaction which is important to the tumor suppression activity of DLC1. Recently, we identified that ... | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | - |
dc.subject | Medical sciences | - |
dc.subject | Oncology | - |
dc.title | Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Ko, FCF: bokcf@hku.hk | - |
dc.identifier.email | Yeung, YS: yeungys@hku.hk | - |
dc.identifier.email | Mao, X: susanmao@hku.hk | - |
dc.identifier.email | Yam, JWP: judyyam@pathology.hku.hk | - |
dc.identifier.authority | Yam, JWP=rp00468 | - |
dc.description.nature | abstract | - |
dc.identifier.doi | 10.1158/1538-7445.AM2014-1565 | - |
dc.identifier.hkuros | 228911 | - |
dc.identifier.volume | 74 | - |
dc.identifier.issue | 19 suppl. | - |
dc.identifier.isi | WOS:000349906901291 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0008-5472 | - |