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Conference Paper: Gene expression noise in transcriptional negative auto-regulation in mammalian cell
| Title | Gene expression noise in transcriptional negative auto-regulation in mammalian cell |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 20, poster no. 15 How to Cite? |
| Abstract | Negative auto-regulation (N.A.R) is the simplest and most widely spread type of genetic network motif. Although previous work has demonstrated that N.A.R can reduce gene expression noise, the dynamic relationship between repression strength and its noise reduction effect has not been well documented in Mammalian cell. Here we construct N.A.R cascades using repressor tetR to suppress its own promoter, which contains different number of tetR binding site, in HEK 293 cell. To measure protein production ... |
| Description | Poster presentation - Theme 1: Cell biology |
| Persistent Identifier | http://hdl.handle.net/10722/203850 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, L | en_US |
| dc.contributor.author | Huang, J | en_US |
| dc.date.accessioned | 2014-09-19T16:42:19Z | - |
| dc.date.available | 2014-09-19T16:42:19Z | - |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 20, poster no. 15 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/203850 | - |
| dc.description | Poster presentation - Theme 1: Cell biology | - |
| dc.description.abstract | Negative auto-regulation (N.A.R) is the simplest and most widely spread type of genetic network motif. Although previous work has demonstrated that N.A.R can reduce gene expression noise, the dynamic relationship between repression strength and its noise reduction effect has not been well documented in Mammalian cell. Here we construct N.A.R cascades using repressor tetR to suppress its own promoter, which contains different number of tetR binding site, in HEK 293 cell. To measure protein production ... | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | Hong Kong Inter-University 2014 Biochemistry Postgraduate Symposium | en_US |
| dc.title | Gene expression noise in transcriptional negative auto-regulation in mammalian cell | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Liu, L: lzliu@hku.hk | en_US |
| dc.identifier.email | Huang, J: jdhuang@hku.hk | en_US |
| dc.identifier.authority | Huang, J=rp00451 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 240327 | en_US |
| dc.identifier.hkuros | 270510 | - |
| dc.identifier.spage | 20, poster no. 15 | - |
| dc.identifier.epage | 20, poster no. 15 | - |