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- Publisher Website: 10.1093/infdis/jiu186
- Scopus: eid_2-s2.0-84907423861
- PMID: 24676208
- WOS: WOS:000344607800003
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Article: Association between antibody titers and protection against influenza virus infection within households
Title | Association between antibody titers and protection against influenza virus infection within households |
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Authors | |
Keywords | Antibody Influenza Family Health Transmission Immunity |
Issue Date | 2014 |
Publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/ |
Citation | Journal of Infectious Diseases , 2014, v. 210 n. 5, p. 684-692 How to Cite? |
Abstract | BACKGROUND: Previous studies have established that antibody titer measured by the hemagglutination-inhibiting (HAI) assay is correlated with protection against influenza virus infection, with an HAI titer of 1:40 generally associated with 50% protection. METHODS: We recruited index cases with confirmed influenza virus infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. Serum samples collected from a subset of household contacts were tested by HAI and microneutralization (MN) assays against prevalent influenza viruses. We analyzed the data using an individual hazard-based transmission model that adjusted for age and vaccination history. RESULTS: Compared to a reference group with antibody titers <1:10, we found that HAI titers of 1:40 against influenza A(H1N1) and A(H3N2) were associated with 31% (95% confidence interval [CI], 13%-46%) and 31% (CI, 1%-53%) protection against polymerase chain reaction (PCR)-confirmed A(H1N1) and A(H3N2) virus infection, respectively, while an MN titer of 1:40 against A(H3N2) was associated with 49% (95% CI, 7%-81%) protection against PCR-confirmed A(H3N2) virus infection. CONCLUSIONS: An HAI titer of 1:40 was associated with substantially less than 50% protection against PCR-confirmed influenza virus infection within households, perhaps because of exposures of greater duration or intensity in that confined setting. |
Persistent Identifier | http://hdl.handle.net/10722/206886 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsang, TK | - |
dc.contributor.author | Cauchemez, S | - |
dc.contributor.author | Perera, RAPM | - |
dc.contributor.author | Freeman, G | - |
dc.contributor.author | Fang, VJ | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.date.accessioned | 2014-12-02T11:14:19Z | - |
dc.date.available | 2014-12-02T11:14:19Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Infectious Diseases , 2014, v. 210 n. 5, p. 684-692 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10722/206886 | - |
dc.description.abstract | BACKGROUND: Previous studies have established that antibody titer measured by the hemagglutination-inhibiting (HAI) assay is correlated with protection against influenza virus infection, with an HAI titer of 1:40 generally associated with 50% protection. METHODS: We recruited index cases with confirmed influenza virus infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. Serum samples collected from a subset of household contacts were tested by HAI and microneutralization (MN) assays against prevalent influenza viruses. We analyzed the data using an individual hazard-based transmission model that adjusted for age and vaccination history. RESULTS: Compared to a reference group with antibody titers <1:10, we found that HAI titers of 1:40 against influenza A(H1N1) and A(H3N2) were associated with 31% (95% confidence interval [CI], 13%-46%) and 31% (CI, 1%-53%) protection against polymerase chain reaction (PCR)-confirmed A(H1N1) and A(H3N2) virus infection, respectively, while an MN titer of 1:40 against A(H3N2) was associated with 49% (95% CI, 7%-81%) protection against PCR-confirmed A(H3N2) virus infection. CONCLUSIONS: An HAI titer of 1:40 was associated with substantially less than 50% protection against PCR-confirmed influenza virus infection within households, perhaps because of exposures of greater duration or intensity in that confined setting. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/ | - |
dc.relation.ispartof | Journal of Infectious Diseases | - |
dc.subject | Antibody | - |
dc.subject | Influenza | - |
dc.subject | Family Health | - |
dc.subject | Transmission | - |
dc.subject | Immunity | - |
dc.title | Association between antibody titers and protection against influenza virus infection within households | - |
dc.type | Article | - |
dc.identifier.email | Perera, RAPM: mahenperera@hku.hk | - |
dc.identifier.email | Freeman, G: gfreeman@hku.hk | - |
dc.identifier.email | Fang, VJ: vickyf@hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Perera, RAPM=rp02500 | - |
dc.identifier.authority | Freeman, G=rp01694 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/infdis/jiu186 | - |
dc.identifier.pmid | 24676208 | - |
dc.identifier.pmcid | PMC4148604 | - |
dc.identifier.scopus | eid_2-s2.0-84907423861 | - |
dc.identifier.hkuros | 241509 | - |
dc.identifier.hkuros | 296996 | - |
dc.identifier.volume | 210 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 684 | - |
dc.identifier.epage | 692 | - |
dc.identifier.isi | WOS:000344607800003 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-1899 | - |