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- Publisher Website: 10.1542/peds.2014-1738
- Scopus: eid_2-s2.0-84920440293
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Article: Methylphenidate and the Risk of Trauma
Title | Methylphenidate and the Risk of Trauma |
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Authors | |
Issue Date | 2015 |
Citation | Pediatrics, 2015, v. 135 n. 1, p. 40-48 How to Cite? |
Abstract | BACKGROUND AND OBJECTIVE: Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are prone to sustaining trauma that requires emergency department (ED) admission. Methylphenidate (MPH) can reduce ADHD symptoms and may thus theoretically reduce the risk of trauma-related ED admission, but previous studies do not make this association clear. This study examines this association. METHODS: A total of 17 381 patients aged 6 to 19 years who received MPH prescriptions were identified by using the Clinical Data Analysis & Reporting System (2001–2013). Using a self-controlled case series study design, the relative incidence of trauma-related ED admissions was compared with periods of patient exposure and nonexposure to MPH. RESULTS: Among 17 381 patients prescribed MPH, 4934 had at least 1 trauma-related ED admission. The rate of trauma-related ED admission was lower during exposed periods compared with non-exposed periods (incidence rate ratio [IRR]: 0.91 [95% confidence interval (CI): 0.86–0.97]). The findings were similar only when the incident trauma episode was assessed (IRR: 0.89 [95% CI: 0.82–0.96]). A similar protective association was found in both genders. In validation analysis using nontrauma-related ED admissions as a negative control outcome, no statistically significant association was found (IRR: 0.99 [95% CI: 0.95–1.02]). All sensitivity analyses demonstrated consistent results. CONCLUSIONS: This study supports the hypothesis that MPH is associated with a reduced risk of trauma- related ED admission in children and adolescents. A similar protective association was found in both male and female patients. This protective association should be considered in clinical practice. |
Persistent Identifier | http://hdl.handle.net/10722/207251 |
ISSN | 2023 Impact Factor: 6.2 2023 SCImago Journal Rankings: 2.437 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Man, KCK | en_US |
dc.contributor.author | Chan, EW | en_US |
dc.contributor.author | Coghill, D | en_US |
dc.contributor.author | Douglas, I | en_US |
dc.contributor.author | Ip, P | en_US |
dc.contributor.author | Leung, LP | en_US |
dc.contributor.author | Tsui, MSH | en_US |
dc.contributor.author | Wong, WHS | en_US |
dc.contributor.author | Wong, ICK | en_US |
dc.date.accessioned | 2014-12-19T09:35:40Z | - |
dc.date.available | 2014-12-19T09:35:40Z | - |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Pediatrics, 2015, v. 135 n. 1, p. 40-48 | en_US |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.uri | http://hdl.handle.net/10722/207251 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE: Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) are prone to sustaining trauma that requires emergency department (ED) admission. Methylphenidate (MPH) can reduce ADHD symptoms and may thus theoretically reduce the risk of trauma-related ED admission, but previous studies do not make this association clear. This study examines this association. METHODS: A total of 17 381 patients aged 6 to 19 years who received MPH prescriptions were identified by using the Clinical Data Analysis & Reporting System (2001–2013). Using a self-controlled case series study design, the relative incidence of trauma-related ED admissions was compared with periods of patient exposure and nonexposure to MPH. RESULTS: Among 17 381 patients prescribed MPH, 4934 had at least 1 trauma-related ED admission. The rate of trauma-related ED admission was lower during exposed periods compared with non-exposed periods (incidence rate ratio [IRR]: 0.91 [95% confidence interval (CI): 0.86–0.97]). The findings were similar only when the incident trauma episode was assessed (IRR: 0.89 [95% CI: 0.82–0.96]). A similar protective association was found in both genders. In validation analysis using nontrauma-related ED admissions as a negative control outcome, no statistically significant association was found (IRR: 0.99 [95% CI: 0.95–1.02]). All sensitivity analyses demonstrated consistent results. CONCLUSIONS: This study supports the hypothesis that MPH is associated with a reduced risk of trauma- related ED admission in children and adolescents. A similar protective association was found in both male and female patients. This protective association should be considered in clinical practice. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Pediatrics | en_US |
dc.title | Methylphenidate and the Risk of Trauma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, KCK: mkckth@hku.hk | en_US |
dc.identifier.email | Chan, EW: ewchan@hku.hk | en_US |
dc.identifier.email | Ip, P: patricip@hku.hk | en_US |
dc.identifier.email | Tsui, MSH: mshtsui@hkucc.hku.hk | en_US |
dc.identifier.email | Wong, WHS: whswong@hku.hk | en_US |
dc.identifier.email | Wong, ICK: wongick@hku.hk | en_US |
dc.identifier.authority | Chan, EW=rp01587 | en_US |
dc.identifier.authority | Ip, P=rp01337 | en_US |
dc.identifier.authority | Wong, ICK=rp01480 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1542/peds.2014-1738 | en_US |
dc.identifier.scopus | eid_2-s2.0-84920440293 | - |
dc.identifier.hkuros | 241950 | en_US |
dc.identifier.hkuros | 281697 | - |
dc.identifier.eissn | 1098-4275 | - |
dc.identifier.isi | WOS:000347172200047 | - |
dc.identifier.issnl | 0031-4005 | - |