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- Publisher Website: 10.5732/cjc.014.10170
- Scopus: eid_2-s2.0-84909969283
- PMID: 25367335
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Article: The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma
Title | The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma |
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Authors | |
Keywords | Cell signaling Epstein-Barr virus Human leukocyte antigen Inflammation NPC genetics |
Issue Date | 2014 |
Publisher | Sun Yat-Sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/ |
Citation | Chinese Journal of Cancer, 2014, v. 33 n. 11, p. 556-568 How to Cite? |
Abstract | The interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen (HLA) complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/211735 |
ISSN | 2019 Impact Factor: 5.760 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lung, ML | - |
dc.contributor.author | Cheung, AKL | - |
dc.contributor.author | Ko, JMY | - |
dc.contributor.author | Lung, HL | - |
dc.contributor.author | Cheng, Y | - |
dc.contributor.author | Dai, W | - |
dc.date.accessioned | 2015-07-21T02:09:25Z | - |
dc.date.available | 2015-07-21T02:09:25Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Chinese Journal of Cancer, 2014, v. 33 n. 11, p. 556-568 | - |
dc.identifier.issn | 1000-467X | - |
dc.identifier.uri | http://hdl.handle.net/10722/211735 | - |
dc.description.abstract | The interplay between host cell genetics and Epstein-Barr virus (EBV) infection contributes to the development of nasopharyngeal carcinoma (NPC). Understanding the host genetic and epigenetic alterations and the influence of EBV on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of NPC and provide useful biomarkers and targets for diagnosis and therapy. In this review, we provide an update of the oncogenes and tumor suppressor genes associated with NPC, as well as genes associated with NPC risk including those involved in carcinogen detoxification and DNA repair. We also describe the importance of host genetics that govern the human leukocyte antigen (HLA) complex and immune responses, and we describe the impact of EBV infection on host cell signaling changes and epigenetic regulation of gene expression. High-power genomic sequencing approaches are needed to elucidate the genetic basis for inherited susceptibility to NPC and to identify the genes and pathways driving its molecular pathogenesis. | - |
dc.language | eng | - |
dc.publisher | Sun Yat-Sen University Cancer Center. The Journal's web site is located at http://www.cjcsysu.cn/ | - |
dc.relation.ispartof | Chinese Journal of Cancer | - |
dc.subject | Cell signaling | - |
dc.subject | Epstein-Barr virus | - |
dc.subject | Human leukocyte antigen | - |
dc.subject | Inflammation | - |
dc.subject | NPC genetics | - |
dc.title | The interplay of host genetic factors and Epstein-Barr virus in the development of nasopharyngeal carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Lung, ML: mlilung@hku.hk | - |
dc.identifier.email | Cheung, AKL: arthurhk@hku.hk | - |
dc.identifier.email | Ko, JMY: joko@hku.hk | - |
dc.identifier.email | Lung, HL: hllung2@hku.hk | - |
dc.identifier.email | Cheng, Y: yuecheng@HKUCC-COM.hku.hk | - |
dc.identifier.email | Dai, W: weidai2@hku.hk | - |
dc.identifier.authority | Lung, ML=rp00300 | - |
dc.identifier.authority | Cheung, AKL=rp01769 | - |
dc.identifier.authority | Ko, JMY=rp02011 | - |
dc.identifier.authority | Lung, HL=rp00299 | - |
dc.identifier.authority | Cheng, Y=rp01320 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.5732/cjc.014.10170 | - |
dc.identifier.pmid | 25367335 | - |
dc.identifier.pmcid | PMC4244319 | - |
dc.identifier.scopus | eid_2-s2.0-84909969283 | - |
dc.identifier.hkuros | 244292 | - |
dc.identifier.hkuros | 244976 | - |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 556 | - |
dc.identifier.epage | 568 | - |
dc.identifier.isi | WOS:000345261300006 | - |
dc.publisher.place | China | - |
dc.identifier.issnl | 1000-467X | - |