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Conference Paper: Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133
Title | Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133 |
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Authors | |
Keywords | Medical sciences Oncology |
Issue Date | 2014 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | Proceedings of the 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. LB-53 How to Cite? |
Abstract | Tumor relapse after therapy typifies hepatocellular carcinoma (HCC) and is believed to be attributable to residual cancer stem cells (CSCs) that survive initial treatment. We have previously identified a CSC population derived from HCC that is characterized by the expression of the transmembrane glycoprotein, CD133. Despite our growing knowledge of the importance of a functional CD133+ liver CSC subset in driving HCC, the regulatory mechanism of CD133 is not known. Epigenetic changes are believed to be essential in the control of cancer and stem cells. We report here the dynamic epigenetic regulation of the functional liver CSC marker CD133 by promoter methylation and miR-142-3p regulation. Unlike in other tumor types, we found DNA methylation to only play a minor role in the control of CD133 expression in HCC. More importantly, our results revealed that miR-142-3p plays an integral part in the direct targeting of ... |
Description | This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA |
Persistent Identifier | http://hdl.handle.net/10722/214788 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ng, KY | - |
dc.contributor.author | Chai, S | - |
dc.contributor.author | Tong, M | - |
dc.contributor.author | Kwan, PS | - |
dc.contributor.author | Chan, YP | - |
dc.contributor.author | Lee, KW | - |
dc.contributor.author | Wong, N | - |
dc.contributor.author | Guan, XY | - |
dc.contributor.author | Ma, S | - |
dc.date.accessioned | 2015-08-21T11:55:45Z | - |
dc.date.available | 2015-08-21T11:55:45Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Proceedings of the 105th Annual Meeting of the American Association for Cancer Research (AACR 2014), San Diego, CA., 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19 suppl., abstract no. LB-53 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/10722/214788 | - |
dc.description | This journal suppl. entitled: Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA | - |
dc.description.abstract | Tumor relapse after therapy typifies hepatocellular carcinoma (HCC) and is believed to be attributable to residual cancer stem cells (CSCs) that survive initial treatment. We have previously identified a CSC population derived from HCC that is characterized by the expression of the transmembrane glycoprotein, CD133. Despite our growing knowledge of the importance of a functional CD133+ liver CSC subset in driving HCC, the regulatory mechanism of CD133 is not known. Epigenetic changes are believed to be essential in the control of cancer and stem cells. We report here the dynamic epigenetic regulation of the functional liver CSC marker CD133 by promoter methylation and miR-142-3p regulation. Unlike in other tumor types, we found DNA methylation to only play a minor role in the control of CD133 expression in HCC. More importantly, our results revealed that miR-142-3p plays an integral part in the direct targeting of ... | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | - |
dc.relation.ispartof | Cancer Research | - |
dc.subject | Medical sciences | - |
dc.subject | Oncology | - |
dc.title | Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133 | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Ng, KY: jkyng@hku.hk | - |
dc.identifier.email | Tong, M: caroltm@hku.hk | - |
dc.identifier.email | Lee, KW: tkwlee@hkucc.hku.hk | - |
dc.identifier.email | Guan, XY: xyguan@hkucc.hku.hk | - |
dc.identifier.email | Ma, S: stefma@hku.hk | - |
dc.identifier.authority | Lee, KW=rp00447 | - |
dc.identifier.authority | Guan, XY=rp00454 | - |
dc.identifier.authority | Ma, S=rp00506 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1158/1538-7445.AM2014-LB-53 | - |
dc.identifier.hkuros | 248965 | - |
dc.identifier.hkuros | 276958 | - |
dc.identifier.volume | 74 | - |
dc.identifier.issue | 19 suppl. | - |
dc.identifier.isi | WOS:000349910205388 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0008-5472 | - |