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Conference Paper: Outcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus
Title | Outcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus |
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Authors | |
Issue Date | 2015 |
Citation | The 11th World IHPBA Congress, Seoul, Korea, 22–27 March 2014. In HPB, 2015, v. 17, n. 5, p. 401-408 How to Cite? |
Abstract | BACKGROUND:
Hepatocellular carcinoma (HCC) with bile duct tumour thrombus (BDTT) is rare. The aim of the present study was to determine the prognosis of HCC with BDTT after a hepatectomy.
METHODS:
A retrospective analysis was performed on all HCC patients with BDTT having a hepatectomy from 1989 to 2012. The outcomes in these patients were compared with those in the control patients matched on a 1:6 ratio.
RESULTS:
Thirty-seven HCC patients with BDTT having a hepatectomy (the BDTT group) were compared with 222 control patients. Patients in the BDTT group had poorer liver function (43.2% had Child-Pugh B disease). More patients in this group had a major hepatectomy (91.9% versus 27.5%, P = 0.001), portal vein resection (10.8% versus 1.4%, P = 0.006), en-bloc resection with adjacent structures (16.2% versus 5.4%, P = 0.041), hepaticojejunostomy (75.7% versus 1.6%, P < 0.001) and complications (51.4% versus 31.1%, P = 0.016). The two groups had similar hospital mortality (2.7% versus 5.0%, P = 0.856), 5-year overall survival (38.5% versus 34.6%, P = 0.59) and 5-year disease-free survival (21.1% versus 20.8%, P = 0.81). Multivariate analysis showed that lymphovascular permeation, tumour size and post-operative complication were significant predictors for worse survival whereas BDTT was not.
DISCUSSION:
A major hepatectomy, extrahepatic biliary resection and hepaticojejunostomy should be the standard for HCC with BDTT, and long-term survival is possible after radical surgery.
© 2014 International Hepato-Pancreato-Biliary Association. |
Description | This study was presented at the 11th World IHPBA Congress, 22–27 March 2014, Seoul. |
Persistent Identifier | http://hdl.handle.net/10722/221378 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.141 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, TCL | - |
dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Dai, WC | - |
dc.contributor.author | Chan, SC | - |
dc.contributor.author | Poon, RTP | - |
dc.contributor.author | Fan, ST | - |
dc.contributor.author | Lo, CM | - |
dc.date.accessioned | 2015-11-18T06:09:09Z | - |
dc.date.available | 2015-11-18T06:09:09Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 11th World IHPBA Congress, Seoul, Korea, 22–27 March 2014. In HPB, 2015, v. 17, n. 5, p. 401-408 | - |
dc.identifier.issn | 1365-182X | - |
dc.identifier.uri | http://hdl.handle.net/10722/221378 | - |
dc.description | This study was presented at the 11th World IHPBA Congress, 22–27 March 2014, Seoul. | - |
dc.description.abstract | BACKGROUND: Hepatocellular carcinoma (HCC) with bile duct tumour thrombus (BDTT) is rare. The aim of the present study was to determine the prognosis of HCC with BDTT after a hepatectomy. METHODS: A retrospective analysis was performed on all HCC patients with BDTT having a hepatectomy from 1989 to 2012. The outcomes in these patients were compared with those in the control patients matched on a 1:6 ratio. RESULTS: Thirty-seven HCC patients with BDTT having a hepatectomy (the BDTT group) were compared with 222 control patients. Patients in the BDTT group had poorer liver function (43.2% had Child-Pugh B disease). More patients in this group had a major hepatectomy (91.9% versus 27.5%, P = 0.001), portal vein resection (10.8% versus 1.4%, P = 0.006), en-bloc resection with adjacent structures (16.2% versus 5.4%, P = 0.041), hepaticojejunostomy (75.7% versus 1.6%, P < 0.001) and complications (51.4% versus 31.1%, P = 0.016). The two groups had similar hospital mortality (2.7% versus 5.0%, P = 0.856), 5-year overall survival (38.5% versus 34.6%, P = 0.59) and 5-year disease-free survival (21.1% versus 20.8%, P = 0.81). Multivariate analysis showed that lymphovascular permeation, tumour size and post-operative complication were significant predictors for worse survival whereas BDTT was not. DISCUSSION: A major hepatectomy, extrahepatic biliary resection and hepaticojejunostomy should be the standard for HCC with BDTT, and long-term survival is possible after radical surgery. © 2014 International Hepato-Pancreato-Biliary Association. | - |
dc.language | eng | - |
dc.relation.ispartof | HPB | - |
dc.subject.mesh | Bile Ducts - surgery | - |
dc.subject.mesh | Carcinoma, Hepatocellular - complications/diagnosis - surgery | - |
dc.subject.mesh | Hepatectomy - methods | - |
dc.subject.mesh | Liver Neoplasms - complications/diagnosis - surgery | - |
dc.subject.mesh | Thrombosis - diagnosis - etiology - surgery | - |
dc.title | Outcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/hpb.12368 | - |
dc.identifier.pmcid | PMC4402050 | - |
dc.identifier.scopus | eid_2-s2.0-84927515203 | - |
dc.identifier.hkuros | 241968 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 401 | - |
dc.identifier.epage | 408 | - |
dc.identifier.eissn | 1477-2574 | - |
dc.identifier.isi | WOS:000352796600004 | - |
dc.customcontrol.immutable | sml 170228 amended | - |
dc.identifier.issnl | 1365-182X | - |