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- Publisher Website: 10.1002/hipo.10017
- Scopus: eid_2-s2.0-0035986210
- PMID: 12099490
- WOS: WOS:000176246600010
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Article: Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus
Title | Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus |
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Authors | |
Keywords | CA1 |
Issue Date | 2002 |
Citation | Hippocampus, 2002, v. 12, n. 3, p. 398-404 How to Cite? |
Abstract | Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cessation of the environmental manipulation remain unknown. Using a novelty exposure procedure modified from the method of neonatal handling, we exposed neonatal rats to a non-home environment for 3 min/day during the first 3 weeks of life. We examined the LTP of both population spikes and excitatory postsynaptic potentials (EPSPs), in vitro, in the CA1 of the hippocampus during adulthood (7-8 and 13-14 months of age). We found that both the LTP of population spikes and the LTP of EPSPs were enhanced among animals who experienced neonatal novelty exposure. These results demonstrate that effective environmental enhancement of LTP can be achieved by as brief and as transient a manipulation as a 3-min/day exposure over the first 3 weeks of life. The resulting enhancement can outlast the environmental manipulation by at least 1 year. © 2002 Wiley-Liss, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/228014 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 1.115 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tang, Akaysha C. | - |
dc.contributor.author | Zou, Bende | - |
dc.date.accessioned | 2016-08-01T06:44:58Z | - |
dc.date.available | 2016-08-01T06:44:58Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Hippocampus, 2002, v. 12, n. 3, p. 398-404 | - |
dc.identifier.issn | 1050-9631 | - |
dc.identifier.uri | http://hdl.handle.net/10722/228014 | - |
dc.description.abstract | Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cessation of the environmental manipulation remain unknown. Using a novelty exposure procedure modified from the method of neonatal handling, we exposed neonatal rats to a non-home environment for 3 min/day during the first 3 weeks of life. We examined the LTP of both population spikes and excitatory postsynaptic potentials (EPSPs), in vitro, in the CA1 of the hippocampus during adulthood (7-8 and 13-14 months of age). We found that both the LTP of population spikes and the LTP of EPSPs were enhanced among animals who experienced neonatal novelty exposure. These results demonstrate that effective environmental enhancement of LTP can be achieved by as brief and as transient a manipulation as a 3-min/day exposure over the first 3 weeks of life. The resulting enhancement can outlast the environmental manipulation by at least 1 year. © 2002 Wiley-Liss, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Hippocampus | - |
dc.subject | CA1 | - |
dc.title | Neonatal exposure to novelty enhances long-term potentiation in CA1 of the rat hippocampus | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/hipo.10017 | - |
dc.identifier.pmid | 12099490 | - |
dc.identifier.scopus | eid_2-s2.0-0035986210 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 398 | - |
dc.identifier.epage | 404 | - |
dc.identifier.isi | WOS:000176246600010 | - |
dc.identifier.issnl | 1050-9631 | - |