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- Publisher Website: 10.1093/aje/kwv110
- Scopus: eid_2-s2.0-84944235926
- PMID: 26400854
- WOS: WOS:000362786700007
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Article: Comparative Epidemiology of Influenza B Yamagata- and Victoria-Lineage Viruses in Households
Title | Comparative Epidemiology of Influenza B Yamagata- and Victoria-Lineage Viruses in Households |
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Authors | |
Keywords | Disease transmission Influenza Influenza B virus Victoria lineage Yamagata lineage |
Issue Date | 2015 |
Publisher | Oxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/ |
Citation | American Journal of Epidemiology, 2015, v. 182 n. 8, p. 705-713 How to Cite? |
Abstract | Influenza B viruses split into 2 distinct lineages in the early 1980s, commonly named the Victoria and Yamagata lineages. There are few data on the comparative epidemiology of Victoria- and Yamagata-lineage viruses. In 2007–2011, we enrolled 75 and 34 households containing index patients with acute respiratory illness who tested positive for Yamagata- and Victoria-lineage viruses, respectively, from outpatient clinics in Hong Kong, China. These index patients and their household contacts were followed up for 7–10 days. We examined overall risk of polymerase chain reaction–confirmed infection among household contacts and the risk of secondary infection within households using an individual-based hazard model that accounted for tertiary transmission and infections occurring outside the household. We found that for Victoria-lineage viruses, the risk of within-household infection among household contacts aged ≤15 years was significantly higher (risk ratio = 12.9, 95% credibility interval: 4.2, 43.6) than that for older household contacts, while for Yamagata-lineage viruses, the risk of within-household infection for household contacts did not differ by age. Influenza B Yamagata- and Victoria-lineage viruses have similar characteristics in terms of viral shedding and clinical illness. The mechanisms underlying these epidemiologic differences deserve further investigation. |
Persistent Identifier | http://hdl.handle.net/10722/230488 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 0.837 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, C | - |
dc.contributor.author | Chan, KH | - |
dc.contributor.author | Tsang, TK | - |
dc.contributor.author | Fang, VJ | - |
dc.contributor.author | Fung, ROP | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Cauchemez, S | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.date.accessioned | 2016-08-23T14:17:19Z | - |
dc.date.available | 2016-08-23T14:17:19Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | American Journal of Epidemiology, 2015, v. 182 n. 8, p. 705-713 | - |
dc.identifier.issn | 0002-9262 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230488 | - |
dc.description.abstract | Influenza B viruses split into 2 distinct lineages in the early 1980s, commonly named the Victoria and Yamagata lineages. There are few data on the comparative epidemiology of Victoria- and Yamagata-lineage viruses. In 2007–2011, we enrolled 75 and 34 households containing index patients with acute respiratory illness who tested positive for Yamagata- and Victoria-lineage viruses, respectively, from outpatient clinics in Hong Kong, China. These index patients and their household contacts were followed up for 7–10 days. We examined overall risk of polymerase chain reaction–confirmed infection among household contacts and the risk of secondary infection within households using an individual-based hazard model that accounted for tertiary transmission and infections occurring outside the household. We found that for Victoria-lineage viruses, the risk of within-household infection among household contacts aged ≤15 years was significantly higher (risk ratio = 12.9, 95% credibility interval: 4.2, 43.6) than that for older household contacts, while for Yamagata-lineage viruses, the risk of within-household infection for household contacts did not differ by age. Influenza B Yamagata- and Victoria-lineage viruses have similar characteristics in terms of viral shedding and clinical illness. The mechanisms underlying these epidemiologic differences deserve further investigation. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/ | - |
dc.relation.ispartof | American Journal of Epidemiology | - |
dc.subject | Disease transmission | - |
dc.subject | Influenza | - |
dc.subject | Influenza B virus | - |
dc.subject | Victoria lineage | - |
dc.subject | Yamagata lineage | - |
dc.title | Comparative Epidemiology of Influenza B Yamagata- and Victoria-Lineage Viruses in Households | - |
dc.type | Article | - |
dc.identifier.email | Xu, C: xuceline@hku.hk | - |
dc.identifier.email | Chan, KH: chankh2@hkucc.hku.hk | - |
dc.identifier.email | Tsang, TK: matklab@hku.hk | - |
dc.identifier.email | Fang, VJ: vickyf@hku.hk | - |
dc.identifier.email | Fung, ROP: ropfung@hkucc.hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Chan, KH=rp01921 | - |
dc.identifier.authority | Tsang, TK=rp02571 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/aje/kwv110 | - |
dc.identifier.pmid | 26400854 | - |
dc.identifier.pmcid | PMC4715237 | - |
dc.identifier.scopus | eid_2-s2.0-84944235926 | - |
dc.identifier.hkuros | 260235 | - |
dc.identifier.volume | 182 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 705 | - |
dc.identifier.epage | 713 | - |
dc.identifier.isi | WOS:000362786700007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0002-9262 | - |