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- Publisher Website: 10.1017/S0950268816000583
- Scopus: eid_2-s2.0-84961943347
- PMID: 27018720
- WOS: WOS:000379785200009
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Article: Quantifying homologous and heterologous antibody titre rises after influenza virus infection
Title | Quantifying homologous and heterologous antibody titre rises after influenza virus infection |
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Authors | |
Keywords | Antibody epidemiology influenza serology |
Issue Date | 2016 |
Publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG |
Citation | Epidemiology and Infection, 2016, v. 144 n. 11, p. 2306-2316 How to Cite? |
Abstract | Most influenza virus infections are associated with mild disease. One approach to estimate the occurrence of influenza virus infections in individuals is via repeated measurement of humoral antibody titres. We used baseline and convalescent antibody titres measured by haemagglutination inhibition (HI) and viral neutralization (VN) assays against influenza A(H1N1), A(H3N2) and B viruses to investigate the characteristics of antibody rises following virologically confirmed influenza virus infections in participants in a community-based study. Multivariate models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following influenza A virus infections. In 122 participants with PCR-confirmed influenza A virus infection, homologous antibody titres rose by geometric means of 1·2- to 10·2-fold after infection with A(H1N1), A(H3N2) and A(H1N1)pdm09. Significant cross-reactions were observed between A(H1N1)pdm09 and seasonal A(H1N1). Antibody titre rises for some subtypes and assays varied by age, receipt of oseltamivir treatment, and recent receipt of influenza vaccination. In conclusion, we provided a quantitative description of the mean and variation in rises in influenza virus antibody titres following influenza virus infection. The multivariate patterns in boosting of antibody titres following influenza virus infection could be taken into account to improve estimates of cumulative incidence of infection in seroepidemiological studies. |
Persistent Identifier | http://hdl.handle.net/10722/230492 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.830 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Freeman, G | - |
dc.contributor.author | Perera, RAPM | - |
dc.contributor.author | Ngan, E | - |
dc.contributor.author | Fang, J | - |
dc.contributor.author | Cauchemez, ST | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.date.accessioned | 2016-08-23T14:17:21Z | - |
dc.date.available | 2016-08-23T14:17:21Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Epidemiology and Infection, 2016, v. 144 n. 11, p. 2306-2316 | - |
dc.identifier.issn | 0950-2688 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230492 | - |
dc.description.abstract | Most influenza virus infections are associated with mild disease. One approach to estimate the occurrence of influenza virus infections in individuals is via repeated measurement of humoral antibody titres. We used baseline and convalescent antibody titres measured by haemagglutination inhibition (HI) and viral neutralization (VN) assays against influenza A(H1N1), A(H3N2) and B viruses to investigate the characteristics of antibody rises following virologically confirmed influenza virus infections in participants in a community-based study. Multivariate models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following influenza A virus infections. In 122 participants with PCR-confirmed influenza A virus infection, homologous antibody titres rose by geometric means of 1·2- to 10·2-fold after infection with A(H1N1), A(H3N2) and A(H1N1)pdm09. Significant cross-reactions were observed between A(H1N1)pdm09 and seasonal A(H1N1). Antibody titre rises for some subtypes and assays varied by age, receipt of oseltamivir treatment, and recent receipt of influenza vaccination. In conclusion, we provided a quantitative description of the mean and variation in rises in influenza virus antibody titres following influenza virus infection. The multivariate patterns in boosting of antibody titres following influenza virus infection could be taken into account to improve estimates of cumulative incidence of infection in seroepidemiological studies. | - |
dc.language | eng | - |
dc.publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG | - |
dc.relation.ispartof | Epidemiology and Infection | - |
dc.rights | Epidemiology and Infection. Copyright © Cambridge University Press. | - |
dc.rights | This article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder. | - |
dc.subject | Antibody | - |
dc.subject | epidemiology | - |
dc.subject | influenza | - |
dc.subject | serology | - |
dc.title | Quantifying homologous and heterologous antibody titre rises after influenza virus infection | - |
dc.type | Article | - |
dc.identifier.email | Freeman, G: gfreeman@hku.hk | - |
dc.identifier.email | Perera, RAPM: mahenp@hku.hk | - |
dc.identifier.email | Fang, J: vickyf@hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Freeman, G=rp01694 | - |
dc.identifier.authority | Perera, RAPM=rp02500 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1017/S0950268816000583 | - |
dc.identifier.pmid | 27018720 | - |
dc.identifier.scopus | eid_2-s2.0-84961943347 | - |
dc.identifier.hkuros | 260246 | - |
dc.identifier.volume | 144 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 2306 | - |
dc.identifier.epage | 2316 | - |
dc.identifier.isi | WOS:000379785200009 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0950-2688 | - |