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- Publisher Website: 10.1007/978-3-319-18440-1_26
- Scopus: eid_2-s2.0-84940122046
- PMID: 26303486
- WOS: WOS:000362449400027
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Conference Paper: Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea
Title | Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea |
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Authors | |
Keywords | Chemoreceptor NO synthase Obstructive sleep apnea |
Issue Date | 2015 |
Publisher | Springer International Publishing. |
Citation | The 19th International Meeting of the International Society for Arterial Chemoreception (ISAC-19), Leeds, UK., 29 June-3 July 2014. In Advances in Experimental Medicine and Biology, 2015, v. 860, p. 233-237. How to Cite? |
Abstract | The carotid body functions to maintain the blood gas homeostasis, whereas anomalous carotid chemoreceptor activities could be pathogenic in patients with sleep apnea. Recent findings suggest an upregulation of renin-angiotensin system (Lam SY, Liu Y, Ng KM et al. Exp Physiol 99:220–231, 2014), which could lead to inflammation in the carotid body during intermittent hypoxia (Lam SY, Liu Y, Ng KM et al. Histochem Cell Biol 137:303–317, 2012). In addition, the level of nitric oxide detected in the carotid body was significantly decreased following intermittent hypoxia for days. These locally regulated mechanisms are proposed to be a significant part of the hypoxia-mediated maladaptive changes of the carotid body, which could play a role in the pathophysiological cascade of sleep apnea in patients with an overactivity of the chemoreflex. |
Description | Adv Exp Med Biol v.860 entitled: Arterial Chemoreceptors in Physiology and Pathophysiology |
Persistent Identifier | http://hdl.handle.net/10722/231448 |
ISBN | |
ISSN | 2021 Impact Factor: 3.650 2023 SCImago Journal Rankings: 0.244 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fung, ML | - |
dc.date.accessioned | 2016-09-20T05:23:11Z | - |
dc.date.available | 2016-09-20T05:23:11Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 19th International Meeting of the International Society for Arterial Chemoreception (ISAC-19), Leeds, UK., 29 June-3 July 2014. In Advances in Experimental Medicine and Biology, 2015, v. 860, p. 233-237. | - |
dc.identifier.isbn | 978-3-319-18439-5 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.uri | http://hdl.handle.net/10722/231448 | - |
dc.description | Adv Exp Med Biol v.860 entitled: Arterial Chemoreceptors in Physiology and Pathophysiology | - |
dc.description.abstract | The carotid body functions to maintain the blood gas homeostasis, whereas anomalous carotid chemoreceptor activities could be pathogenic in patients with sleep apnea. Recent findings suggest an upregulation of renin-angiotensin system (Lam SY, Liu Y, Ng KM et al. Exp Physiol 99:220–231, 2014), which could lead to inflammation in the carotid body during intermittent hypoxia (Lam SY, Liu Y, Ng KM et al. Histochem Cell Biol 137:303–317, 2012). In addition, the level of nitric oxide detected in the carotid body was significantly decreased following intermittent hypoxia for days. These locally regulated mechanisms are proposed to be a significant part of the hypoxia-mediated maladaptive changes of the carotid body, which could play a role in the pathophysiological cascade of sleep apnea in patients with an overactivity of the chemoreflex. | - |
dc.language | eng | - |
dc.publisher | Springer International Publishing. | - |
dc.relation.ispartof | Advances in Experimental Medicine and Biology | - |
dc.relation.ispartof | Arterial Chemoreceptors in Physiology and Pathophysiology | - |
dc.subject | Chemoreceptor | - |
dc.subject | NO synthase | - |
dc.subject | Obstructive sleep apnea | - |
dc.title | Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Fung, ML: fungml@hku.hk | - |
dc.identifier.authority | Fung, ML=rp00433 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/978-3-319-18440-1_26 | - |
dc.identifier.pmid | 26303486 | - |
dc.identifier.scopus | eid_2-s2.0-84940122046 | - |
dc.identifier.hkuros | 266077 | - |
dc.identifier.hkuros | 252249 | - |
dc.identifier.spage | 233 | - |
dc.identifier.epage | 237 | - |
dc.identifier.isi | WOS:000362449400027 | - |
dc.publisher.place | Switzerland | - |
dc.customcontrol.immutable | sml 170504 amended | - |
dc.identifier.issnl | 0065-2598 | - |