File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: Individual correlates of infectivity of influenza A virus infections in households
Title | Individual correlates of infectivity of influenza A virus infections in households |
---|---|
Authors | |
Issue Date | 2016 |
Publisher | International Society for Influenza and Other Respiratory Virus Diseases. |
Citation | The 9th International Scientific Conference of Options for the Control of Influenza (Options-9), Chicago, IL., 24-28 August 2016. In Conference Program, 2016, p. 126, abstract no. P-125 How to Cite? |
Abstract | BACKGROUND: Identifying individual correlates of infectivity of influenza virus
is important for disease control and prevention. Viral shedding is used as a
proxy measure of infectivity in many studies. However, the evidence for this is
limited.
METHOD: In a detailed study of influenza virus transmission within households
in 2008-12, we recruited index cases with confirmed influenza infection from
outpatient clinics, and followed up their household contacts for 7-10 days
to identify secondary infections. We used individual-based hazard models to
characterize the relationship between individual viral shedding and individual
infectivity.
RESULTS: We analyzed 386 households with 1147 household contacts. Index
cases were separated into 3 groups according to their estimated level of
viral shedding at symptom onset. We did not find a statistically significant
association of virus shedding with transmission. Index cases in medium and
higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%)
and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower
viral shedding group.
CONCLUSION: Individual levels of viral shedding measured by RT-PCR in the nose
and throat was not strongly correlated with individual infectivity in households.
Our study was underpowered to confirm a possible weak to moderate
association of viral shedding with infectivity. Other correlates of infectivity
should be examined in future studies. |
Description | Poster Sessions: no. P-125 |
Persistent Identifier | http://hdl.handle.net/10722/233611 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tsang, KL | - |
dc.contributor.author | Fang, J | - |
dc.contributor.author | Chan, KH | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.contributor.author | Cauchemez, ST | - |
dc.date.accessioned | 2016-09-20T05:37:56Z | - |
dc.date.available | 2016-09-20T05:37:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | The 9th International Scientific Conference of Options for the Control of Influenza (Options-9), Chicago, IL., 24-28 August 2016. In Conference Program, 2016, p. 126, abstract no. P-125 | - |
dc.identifier.uri | http://hdl.handle.net/10722/233611 | - |
dc.description | Poster Sessions: no. P-125 | - |
dc.description.abstract | BACKGROUND: Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. METHOD: In a detailed study of influenza virus transmission within households in 2008-12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7-10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. RESULTS: We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. CONCLUSION: Individual levels of viral shedding measured by RT-PCR in the nose and throat was not strongly correlated with individual infectivity in households. Our study was underpowered to confirm a possible weak to moderate association of viral shedding with infectivity. Other correlates of infectivity should be examined in future studies. | - |
dc.language | eng | - |
dc.publisher | International Society for Influenza and Other Respiratory Virus Diseases. | - |
dc.relation.ispartof | ISIRV Options-9 Conference | - |
dc.title | Individual correlates of infectivity of influenza A virus infections in households | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Tsang, KL: matklab@hku.hk | - |
dc.identifier.email | Fang, J: vickyf@hku.hk | - |
dc.identifier.email | Chan, KH: chankh2@hkucc.hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Chan, KH=rp01921 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.identifier.hkuros | 266502 | - |
dc.identifier.hkuros | 270572 | - |
dc.identifier.spage | 126, abstract no. P-125 | - |
dc.identifier.epage | 126, abstract no. P-125 | - |
dc.publisher.place | United States | - |