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Conference Paper: Combined auditory and optogenetic fMRI for investigation of visual cortical descending modulation of auditory midbrain processing
| Title | Combined auditory and optogenetic fMRI for investigation of visual cortical descending modulation of auditory midbrain processing |
|---|---|
| Authors | |
| Issue Date | 2016 |
| Citation | The 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore, 7-13 May 2016. How to Cite? |
| Abstract | In the auditory system, the midbrain inferior colliculus (IC) receives massive corticofugal projections, yet their functional implications remain unclear. Previous studies utilizing single neuron recordings and electrical activation or cryogenical inactivation of the cortex could not provide a cell-type specific understanding of the large-scale corticofugal modulation effects. This study combines auditory and optogenetic fMRI to investigate the corticofugal influences on auditory midbrain processing. Large-view fMRI was used to monitor the IC noise response during cell-type specific optogenetic stimulation of the VC. The results demonstrate the feasibility of this novel approach and show that VC normally facilitates auditory midbrain responses. |
| Description | Scientific Session - fMRI Basic Neuroscience, Including Optogenetics: no. 0481 |
| Persistent Identifier | http://hdl.handle.net/10722/234976 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gao, PP | - |
| dc.contributor.author | Chan, RW | - |
| dc.contributor.author | Leong, ATL | - |
| dc.contributor.author | Dong, CM | - |
| dc.contributor.author | Wu, EX | - |
| dc.date.accessioned | 2016-10-14T13:50:29Z | - |
| dc.date.available | 2016-10-14T13:50:29Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.citation | The 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore, 7-13 May 2016. | - |
| dc.identifier.uri | http://hdl.handle.net/10722/234976 | - |
| dc.description | Scientific Session - fMRI Basic Neuroscience, Including Optogenetics: no. 0481 | - |
| dc.description.abstract | In the auditory system, the midbrain inferior colliculus (IC) receives massive corticofugal projections, yet their functional implications remain unclear. Previous studies utilizing single neuron recordings and electrical activation or cryogenical inactivation of the cortex could not provide a cell-type specific understanding of the large-scale corticofugal modulation effects. This study combines auditory and optogenetic fMRI to investigate the corticofugal influences on auditory midbrain processing. Large-view fMRI was used to monitor the IC noise response during cell-type specific optogenetic stimulation of the VC. The results demonstrate the feasibility of this novel approach and show that VC normally facilitates auditory midbrain responses. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM 2016 | - |
| dc.title | Combined auditory and optogenetic fMRI for investigation of visual cortical descending modulation of auditory midbrain processing | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
| dc.identifier.authority | Wu, EX=rp00193 | - |
| dc.identifier.hkuros | 268577 | - |