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Article: Zinc intake, zinc bioavailability and plasma zinc in obese adolescents with clinical insulin resistance following low energy diets
Title | Zinc intake, zinc bioavailability and plasma zinc in obese adolescents with clinical insulin resistance following low energy diets |
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Authors | |
Keywords | Obesity Phytate Zinc Adolescents Insulin resistance |
Issue Date | 2016 |
Citation | Annals of Nutrition and Metabolism, 2016, v. 69, n. 2, p. 135-141 How to Cite? |
Abstract | © 2016 S. Karger AG, Basel.Background: Zinc has a critical role in metabolism and growth. This study aims to determine the effects of low-energy diets differing in macronutrient composition on zinc intake, estimated zinc bioavailability (phytate:zinc molar ratio) and plasma zinc concentration and associations between zinc status and cardiometabolic markers in obese adolescents with clinical insulin resistance (IR). Methods: Eighty-seven obese adolescents (10-17 years, body mass index z-score 2.3 ± 0.37) with clinical IR were randomized to a low-energy diet (6.0-8.0 MJ), which was either high carbohydrate or moderate carbohydrate with increased protein. Twenty-four-hour dietary recalls were collected at 6, 9 and 12 weeks. Plasma zinc concentration and cardiometabolic markers were assessed at baseline and 12 weeks. Results: Zinc intake did not differ between the 2 diet groups (p = 0.612). The high-carbohydrate group had a higher phytate intake (894 vs. 671 mg, p = 0.018) and phytate:zinc molar ratio (9.4 vs. 7.4, p = 0.009) than the increased-protein group. Plasma zinc concentration did not change from baseline in either of the diet groups, but correlated positively with zinc intake (r = 0.235, p = 0.042) and % energy from protein (r = 0.383, p = 0.001), and inversely with % energy from carbohydrate (r = -0.296, p = 0.010). Conclusions: Low energy diets for obese adolescents at risk of diabetes may need increased protein content to optimize zinc bioavailability. |
Persistent Identifier | http://hdl.handle.net/10722/236632 |
ISSN | 2021 Impact Factor: 5.923 2020 SCImago Journal Rankings: 0.926 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, Mandy | - |
dc.contributor.author | Heath, Anne Louise M | - |
dc.contributor.author | Gow, Megan | - |
dc.contributor.author | Baur, Louise A. | - |
dc.contributor.author | Cowell, Chris T. | - |
dc.contributor.author | Samman, Samir | - |
dc.contributor.author | Garnett, Sarah P. | - |
dc.date.accessioned | 2016-12-01T09:08:27Z | - |
dc.date.available | 2016-12-01T09:08:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Annals of Nutrition and Metabolism, 2016, v. 69, n. 2, p. 135-141 | - |
dc.identifier.issn | 0250-6807 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236632 | - |
dc.description.abstract | © 2016 S. Karger AG, Basel.Background: Zinc has a critical role in metabolism and growth. This study aims to determine the effects of low-energy diets differing in macronutrient composition on zinc intake, estimated zinc bioavailability (phytate:zinc molar ratio) and plasma zinc concentration and associations between zinc status and cardiometabolic markers in obese adolescents with clinical insulin resistance (IR). Methods: Eighty-seven obese adolescents (10-17 years, body mass index z-score 2.3 ± 0.37) with clinical IR were randomized to a low-energy diet (6.0-8.0 MJ), which was either high carbohydrate or moderate carbohydrate with increased protein. Twenty-four-hour dietary recalls were collected at 6, 9 and 12 weeks. Plasma zinc concentration and cardiometabolic markers were assessed at baseline and 12 weeks. Results: Zinc intake did not differ between the 2 diet groups (p = 0.612). The high-carbohydrate group had a higher phytate intake (894 vs. 671 mg, p = 0.018) and phytate:zinc molar ratio (9.4 vs. 7.4, p = 0.009) than the increased-protein group. Plasma zinc concentration did not change from baseline in either of the diet groups, but correlated positively with zinc intake (r = 0.235, p = 0.042) and % energy from protein (r = 0.383, p = 0.001), and inversely with % energy from carbohydrate (r = -0.296, p = 0.010). Conclusions: Low energy diets for obese adolescents at risk of diabetes may need increased protein content to optimize zinc bioavailability. | - |
dc.language | eng | - |
dc.relation.ispartof | Annals of Nutrition and Metabolism | - |
dc.subject | Obesity | - |
dc.subject | Phytate | - |
dc.subject | Zinc | - |
dc.subject | Adolescents | - |
dc.subject | Insulin resistance | - |
dc.title | Zinc intake, zinc bioavailability and plasma zinc in obese adolescents with clinical insulin resistance following low energy diets | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000450728 | - |
dc.identifier.scopus | eid_2-s2.0-84991810692 | - |
dc.identifier.volume | 69 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 135 | - |
dc.identifier.epage | 141 | - |
dc.identifier.eissn | 1421-9697 | - |
dc.identifier.isi | WOS:000388417300057 | - |
dc.identifier.issnl | 0250-6807 | - |