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- Publisher Website: 10.1210/jc.2014-1944
- Scopus: eid_2-s2.0-84907647157
- PMID: 24955610
- WOS: WOS:000343423300004
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Article: Effect of fat loss on arterial elasticity in obese adolescents with clinical insulin resistance: RESIST study
Title | Effect of fat loss on arterial elasticity in obese adolescents with clinical insulin resistance: RESIST study |
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Authors | |
Issue Date | 2014 |
Citation | Journal of Clinical Endocrinology and Metabolism, 2014, v. 99, n. 10, p. E1846-E1853 How to Cite? |
Abstract | Copyright © 2014 by the Endocrine Society.Context: Reduced arterial elasticity contributesto an obesity-related increase in cardiovascular risk in adults.Objective: To evaluate the effect of fat loss on arterial elasticity in obese adolescents at risk of type 2 diabetes.Design: A secondary data analysis of the RESIST study was performed in two hospitals in Sydney, Australia.Participants: The study included 56 subjects (ages, 10 to 17 y; 25 males) with prediabetes and/or clinical features of insulin resistance.Intervention: A 12-month lifestyle plus metformin intervention.Outcomes: Arterial elasticity and systemic vascular resistance were measured using radial tonometry pulse contour analysis, percentage body fat (%BF) was measured by dual-energy x-ray absorptiometry, and insulin sensitivity index was derived from an oral glucose tolerance test and lipids.Results: Adolescents (n = 31) with decreased %BF (mean change [range], -4.4% [-18.3 to -0.01%]) afterthe intervention had significant increases in the mean large arterial elasticity index (mean change [95%CI], 5.1 [1.9 to 8.2] mL/mm Hg ∗ 10; P =.003) and insulin sensitivity index (0.5 [0.1 to 0.9]; P =.010) and a decrease in systemic vascular resistance (-82 [-129 to -35] dyne ∗ s ∗ cm-5; P =.001). There were no significant changes in these parameters in adolescents who increased their %BF. Nor was there any significant change in the mean small arterial elasticity index in either group.Conclusion: Long-term follow-up of these adolescents is warranted to assess whether the observed changes in vascular elasticity will lead to a clinical benefit including reduced cardiovascular morbidity and mortality. |
Persistent Identifier | http://hdl.handle.net/10722/236684 |
ISSN | 2021 Impact Factor: 6.134 2020 SCImago Journal Rankings: 2.206 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, Mandy | - |
dc.contributor.author | Gow, Megan | - |
dc.contributor.author | Baur, Louise A. | - |
dc.contributor.author | Benitez-Aguirre, Paul Z. | - |
dc.contributor.author | Tam, Charmaine S. | - |
dc.contributor.author | Donaghue, Kim C. | - |
dc.contributor.author | Craig, Maria E. | - |
dc.contributor.author | Cowell, Chris T. | - |
dc.contributor.author | Garnett, Sarah P. | - |
dc.date.accessioned | 2016-12-01T09:08:36Z | - |
dc.date.available | 2016-12-01T09:08:36Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2014, v. 99, n. 10, p. E1846-E1853 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | http://hdl.handle.net/10722/236684 | - |
dc.description.abstract | Copyright © 2014 by the Endocrine Society.Context: Reduced arterial elasticity contributesto an obesity-related increase in cardiovascular risk in adults.Objective: To evaluate the effect of fat loss on arterial elasticity in obese adolescents at risk of type 2 diabetes.Design: A secondary data analysis of the RESIST study was performed in two hospitals in Sydney, Australia.Participants: The study included 56 subjects (ages, 10 to 17 y; 25 males) with prediabetes and/or clinical features of insulin resistance.Intervention: A 12-month lifestyle plus metformin intervention.Outcomes: Arterial elasticity and systemic vascular resistance were measured using radial tonometry pulse contour analysis, percentage body fat (%BF) was measured by dual-energy x-ray absorptiometry, and insulin sensitivity index was derived from an oral glucose tolerance test and lipids.Results: Adolescents (n = 31) with decreased %BF (mean change [range], -4.4% [-18.3 to -0.01%]) afterthe intervention had significant increases in the mean large arterial elasticity index (mean change [95%CI], 5.1 [1.9 to 8.2] mL/mm Hg ∗ 10; P =.003) and insulin sensitivity index (0.5 [0.1 to 0.9]; P =.010) and a decrease in systemic vascular resistance (-82 [-129 to -35] dyne ∗ s ∗ cm-5; P =.001). There were no significant changes in these parameters in adolescents who increased their %BF. Nor was there any significant change in the mean small arterial elasticity index in either group.Conclusion: Long-term follow-up of these adolescents is warranted to assess whether the observed changes in vascular elasticity will lead to a clinical benefit including reduced cardiovascular morbidity and mortality. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Endocrinology and Metabolism | - |
dc.title | Effect of fat loss on arterial elasticity in obese adolescents with clinical insulin resistance: RESIST study | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1210/jc.2014-1944 | - |
dc.identifier.pmid | 24955610 | - |
dc.identifier.scopus | eid_2-s2.0-84907647157 | - |
dc.identifier.volume | 99 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | E1846 | - |
dc.identifier.epage | E1853 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.isi | WOS:000343423300004 | - |
dc.identifier.issnl | 0021-972X | - |