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Article: Comparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome

TitleComparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome
Authors
KeywordsDry eye disease
Rheumatoid arthritis
Sjogren syndrome
Tear osmolarity
Issue Date2017
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corneajrnl.com/
Citation
Cornea, 2017, v. 36 n. 7, p. 805-809 How to Cite?
AbstractPurpose: To compare tear osmolarity (TO) and other dry eye parameters in rheumatoid arthritis (RA) patients with or without secondary Sjogren syndrome (sSS). Methods: Consecutive patients with RA were divided into a sSS group and no-sSS group using conventional diagnostic criteria by rheumatologists using symptomatology, Schirmer test score, and anti-Ro or anti-La autoantibody status. The TO, Ocular Surface Disease Index, dry eye disease (DED) parameters [such as tear breakup time (TBUT) and corneal staining score] and the systemic inflammatory markers [erythrocyte sedimentation rate (ESR) and Creactive protein (CRP)] were compared. Correlation analyses between TO and the DED parameters and inflammatory markers were also performed. Results: A total of 42 cases with mean age 54.8 6 12.3 were included, with 12 patients (29%) having sSS and 30 (71%) without sSS. TO was increased in both groups (329 6 20 and 319 6 25 mOsm/L, respectively), but no statistically significant difference was found between the 2 groups (P = 0.126). RA with sSS had significantly shorter TBUT, higher corneal staining score, and ESR CRP levels (P < 0.05). TO did not correlate with the Schirmer test score, but had significant positive correlations with age, corneal staining score, ESR, and CRP levels, and a significant negative correlation with TBUT. Conclusions: TO was increased in RA patients with or without sSS. There was no significant correlation between TO and the Schirmer test score, and the physician could not use TO to diagnose sSS. However, TO correlated well with both DED parameters (TBUT and corneal staining score) and systemic inflammatory markers (ESR and CRP). © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/240878
ISSN
2019 Impact Factor: 2.215
2015 SCImago Journal Rankings: 1.273
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, LKA-
dc.contributor.authorChoy, NKB-
dc.contributor.authorChan, TCY-
dc.contributor.authorWong, YHI-
dc.contributor.authorLai, JSM-
dc.contributor.authorMok, MYT-
dc.date.accessioned2017-05-22T09:18:42Z-
dc.date.available2017-05-22T09:18:42Z-
dc.date.issued2017-
dc.identifier.citationCornea, 2017, v. 36 n. 7, p. 805-809-
dc.identifier.issn0277-3740-
dc.identifier.urihttp://hdl.handle.net/10722/240878-
dc.description.abstractPurpose: To compare tear osmolarity (TO) and other dry eye parameters in rheumatoid arthritis (RA) patients with or without secondary Sjogren syndrome (sSS). Methods: Consecutive patients with RA were divided into a sSS group and no-sSS group using conventional diagnostic criteria by rheumatologists using symptomatology, Schirmer test score, and anti-Ro or anti-La autoantibody status. The TO, Ocular Surface Disease Index, dry eye disease (DED) parameters [such as tear breakup time (TBUT) and corneal staining score] and the systemic inflammatory markers [erythrocyte sedimentation rate (ESR) and Creactive protein (CRP)] were compared. Correlation analyses between TO and the DED parameters and inflammatory markers were also performed. Results: A total of 42 cases with mean age 54.8 6 12.3 were included, with 12 patients (29%) having sSS and 30 (71%) without sSS. TO was increased in both groups (329 6 20 and 319 6 25 mOsm/L, respectively), but no statistically significant difference was found between the 2 groups (P = 0.126). RA with sSS had significantly shorter TBUT, higher corneal staining score, and ESR CRP levels (P < 0.05). TO did not correlate with the Schirmer test score, but had significant positive correlations with age, corneal staining score, ESR, and CRP levels, and a significant negative correlation with TBUT. Conclusions: TO was increased in RA patients with or without sSS. There was no significant correlation between TO and the Schirmer test score, and the physician could not use TO to diagnose sSS. However, TO correlated well with both DED parameters (TBUT and corneal staining score) and systemic inflammatory markers (ESR and CRP). © 2017 Wolters Kluwer Health, Inc. All rights reserved.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corneajrnl.com/-
dc.relation.ispartofCornea-
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)-
dc.subjectDry eye disease-
dc.subjectRheumatoid arthritis-
dc.subjectSjogren syndrome-
dc.subjectTear osmolarity-
dc.titleComparison of Tear Osmolarity in Rheumatoid Arthritis Patients With and Without Secondary Sjogren Syndrome-
dc.typeArticle-
dc.identifier.emailNg, LKA: nlk008@hku.hk-
dc.identifier.emailChoy, NKB: bnkchoy@hku.hk-
dc.identifier.emailWong, YHI: wongyhi@hku.hk-
dc.identifier.emailLai, JSM: laism@hku.hk-
dc.identifier.emailMok, MYT: temy@hkucc.hku.hk-
dc.identifier.authorityNg, LKA=rp01842-
dc.identifier.authorityChoy, NKB=rp01795-
dc.identifier.authorityWong, YHI=rp01467-
dc.identifier.authorityLai, JSM=rp00295-
dc.identifier.authorityMok, MYT=rp00490-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/ICO.0000000000001227-
dc.identifier.pmid28486313-
dc.identifier.scopuseid_2-s2.0-85020850969-
dc.identifier.hkuros272319-
dc.identifier.volume36-
dc.identifier.issue7-
dc.identifier.spage805-
dc.identifier.epage809-
dc.identifier.isiWOS:000403270200009-
dc.publisher.placeUnited States-
dc.identifier.issnl0277-3740-

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