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Article: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

TitleAssociation between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations
Authors
SEOW, WJMatsuo, KCHUISUNG, CAShiraishi, KSONG, MSKIM, HNWONG, MPHONG, YCHosgood, HDWANG, ZMCHANG, ISPARK, KHLU, DLIU, JJSHEN, HBJEON, HSGUAN, PTAN, WYU, JMWANG, CLSIHOE, ADLKIM, JHCHEN, YCHOI, YYChatterjee, NHUNG, JYRothman, NKIM, JSCHEN, KYOON, HLStevens, VLCAI, QYSU, YCLIN, CCPARK, IKXU, PDONG, JKIM, CHE, QCTUCKER, MKohno, TWU, YLLaird-Offringa, LATSAI, FYPENG, RPCHEN, CYVermeulen, RWU, JJLIM, WYCHEN, KCCHAN, JKCCHU, MJLI, YJLI, JHBerndt, SLSHIN, MHZHOU, BSCHanock, SJWEI, HCHEN, HYYU, CJJIN, LLO, YLCHEN, YHFraumeni, JFCHEN, YSLIU, JMarconett, CNYamaji, TLANDI, MTYANG, YLan, QHICKS, BMitsudomi, TWYATT, KLI, SAYatabe, YDAI, JCMA, HXWANG, PJIN, GFSONG, BCHUNG, LPWANG, ZHCHENG, SSCAPORASO, NELI, XLZHANG, XCREN, YWZHENG, WCUI, PZheng, HIwasaki, MShimazu, TTsugane, SAN, SJZHU, JJJiang, GNGUO, HFEI, KALBANES, DWU, GPCHIEN, LHLAWRENCE, CCHEN, HLKIM, YTSHU, XQHSIAO, CFKIM, YCBASSIG, BACHANG, JHO, JCMHE, XZJU, BTBURDETT, LKUBO, MHU, ZBDAIGO, YSUNG, JSITO, YMomozawa, YAshikawa, KKamatanI, YHonda, TSakamoto, HKunitoh, HWU, WYEAGER, MWANG, WCTSAI, YHTSUTA, KWatanabe, SINokihara, HMiyagi, YNakayama, HMatsumoto, STsuboi, MGOTO, KYIN, ZHSHI, JXWANG, JCSUNG, SWJACOBS, KBWang, JWTakahashi, AGOTO, AMinamiya, YShimizu, KTanaka, KWU, TCWEI, FSJUNG, YJWONG, JYYCHUNG, CCMatsuda, FHutchinson, ASU, JLI, YQKIM, YHOH, IJSONG, FJLee, VHFYANG, TYSU, WCCHEN, YMHU, LMCHANG, GCCHEN, KYLIU, LIHUANG, MSYANG, PCCHOI, JELIN, HCXU, JXIANG, YBSEOW, APARK, JYCHEN, CHKWEON, SSCHEN, CJLI, HXKANG, CHGAO, YTWU, CLIN, DXQIAN, BY
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2017, v. 26 n. 2, p. 454-465 How to Cite?
AbstractTo evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.
DescriptionLink to Free access
Persistent Identifierhttp://hdl.handle.net/10722/240908
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.602
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSEOW, WJ-
dc.contributor.authorMatsuo, KC-
dc.contributor.authorHUISUNG, CA-
dc.contributor.authorShiraishi, K-
dc.contributor.authorSONG, MS-
dc.contributor.authorKIM, HN-
dc.contributor.authorWONG, MP-
dc.contributor.authorHONG, YC-
dc.contributor.authorHosgood, HD-
dc.contributor.authorWANG, ZM-
dc.contributor.authorCHANG, IS-
dc.contributor.authorPARK, KH-
dc.contributor.authorLU, D-
dc.contributor.authorLIU, JJ-
dc.contributor.authorSHEN, HB-
dc.contributor.authorJEON, HS-
dc.contributor.authorGUAN, P-
dc.contributor.authorTAN, W-
dc.contributor.authorYU, JM-
dc.contributor.authorWANG, CL-
dc.contributor.authorSIHOE, ADL-
dc.contributor.authorKIM, JH-
dc.contributor.authorCHEN, Y-
dc.contributor.authorCHOI, YY-
dc.contributor.authorChatterjee, N-
dc.contributor.authorHUNG, JY-
dc.contributor.authorRothman, N-
dc.contributor.authorKIM, JS-
dc.contributor.authorCHEN, K-
dc.contributor.authorYOON, HL-
dc.contributor.authorStevens, VL-
dc.contributor.authorCAI, QY-
dc.contributor.authorSU, YC-
dc.contributor.authorLIN, CC-
dc.contributor.authorPARK, IK-
dc.contributor.authorXU, P-
dc.contributor.authorDONG, J-
dc.contributor.authorKIM, C-
dc.contributor.authorHE, QC-
dc.contributor.authorTUCKER, M-
dc.contributor.authorKohno, T-
dc.contributor.authorWU, YL-
dc.contributor.authorLaird-Offringa, LA-
dc.contributor.authorTSAI, FY-
dc.contributor.authorPENG, RP-
dc.contributor.authorCHEN, CY-
dc.contributor.authorVermeulen, R-
dc.contributor.authorWU, JJ-
dc.contributor.authorLIM, WY-
dc.contributor.authorCHEN, KC-
dc.contributor.authorCHAN, JKC-
dc.contributor.authorCHU, MJ-
dc.contributor.authorLI, YJ-
dc.contributor.authorLI, JH-
dc.contributor.authorBerndt, SL-
dc.contributor.authorSHIN, MH-
dc.contributor.authorZHOU, BS-
dc.contributor.authorCHanock, SJ-
dc.contributor.authorWEI, H-
dc.contributor.authorCHEN, HY-
dc.contributor.authorYU, CJ-
dc.contributor.authorJIN, L-
dc.contributor.authorLO, YL-
dc.contributor.authorCHEN, YH-
dc.contributor.authorFraumeni, JF-
dc.contributor.authorCHEN, YS-
dc.contributor.authorLIU, J-
dc.contributor.authorMarconett, CN-
dc.contributor.authorYamaji, T-
dc.contributor.authorLANDI, MT-
dc.contributor.authorYANG, Y-
dc.contributor.authorLan, Q-
dc.contributor.authorHICKS, B-
dc.contributor.authorMitsudomi, T-
dc.contributor.authorWYATT, K-
dc.contributor.authorLI, SA-
dc.contributor.authorYatabe, Y-
dc.contributor.authorDAI, JC-
dc.contributor.authorMA, HX-
dc.contributor.authorWANG, P-
dc.contributor.authorJIN, GF-
dc.contributor.authorSONG, B-
dc.contributor.authorCHUNG, LP-
dc.contributor.authorWANG, ZH-
dc.contributor.authorCHENG, SS-
dc.contributor.authorCAPORASO, NE-
dc.contributor.authorLI, XL-
dc.contributor.authorZHANG, XC-
dc.contributor.authorREN, YW-
dc.contributor.authorZHENG, W-
dc.contributor.authorCUI, P-
dc.contributor.authorZheng, H-
dc.contributor.authorIwasaki, M-
dc.contributor.authorShimazu, T-
dc.contributor.authorTsugane, S-
dc.contributor.authorAN, SJ-
dc.contributor.authorZHU, JJ-
dc.contributor.authorJiang, GN-
dc.contributor.authorGUO, H-
dc.contributor.authorFEI, K-
dc.contributor.authorALBANES, D-
dc.contributor.authorWU, GP-
dc.contributor.authorCHIEN, LH-
dc.contributor.authorLAWRENCE, C-
dc.contributor.authorCHEN, HL-
dc.contributor.authorKIM, YT-
dc.contributor.authorSHU, XQ-
dc.contributor.authorHSIAO, CF-
dc.contributor.authorKIM, YC-
dc.contributor.authorBASSIG, BA-
dc.contributor.authorCHANG, J-
dc.contributor.authorHO, JCM-
dc.contributor.authorHE, XZ-
dc.contributor.authorJU, BT-
dc.contributor.authorBURDETT, L-
dc.contributor.authorKUBO, M-
dc.contributor.authorHU, ZB-
dc.contributor.authorDAIGO, Y-
dc.contributor.authorSUNG, JS-
dc.contributor.authorITO, Y-
dc.contributor.authorMomozawa, Y-
dc.contributor.authorAshikawa, K-
dc.contributor.authorKamatanI, Y-
dc.contributor.authorHonda, T-
dc.contributor.authorSakamoto, H-
dc.contributor.authorKunitoh, H-
dc.contributor.authorWU, W-
dc.contributor.authorYEAGER, M-
dc.contributor.authorWANG, WC-
dc.contributor.authorTSAI, YH-
dc.contributor.authorTSUTA, K-
dc.contributor.authorWatanabe, SI-
dc.contributor.authorNokihara, H-
dc.contributor.authorMiyagi, Y-
dc.contributor.authorNakayama, H-
dc.contributor.authorMatsumoto, S-
dc.contributor.authorTsuboi, M-
dc.contributor.authorGOTO, K-
dc.contributor.authorYIN, ZH-
dc.contributor.authorSHI, JX-
dc.contributor.authorWANG, JC-
dc.contributor.authorSUNG, SW-
dc.contributor.authorJACOBS, KB-
dc.contributor.authorWang, JW-
dc.contributor.authorTakahashi, A-
dc.contributor.authorGOTO, A-
dc.contributor.authorMinamiya, Y-
dc.contributor.authorShimizu, K-
dc.contributor.authorTanaka, K-
dc.contributor.authorWU, TC-
dc.contributor.authorWEI, FS-
dc.contributor.authorJUNG, YJ-
dc.contributor.authorWONG, JYY-
dc.contributor.authorCHUNG, CC-
dc.contributor.authorMatsuda, F-
dc.contributor.authorHutchinson, A-
dc.contributor.authorSU, J-
dc.contributor.authorLI, YQ-
dc.contributor.authorKIM, YH-
dc.contributor.authorOH, IJ-
dc.contributor.authorSONG, FJ-
dc.contributor.authorLee, VHF-
dc.contributor.authorYANG, TY-
dc.contributor.authorSU, WC-
dc.contributor.authorCHEN, YM-
dc.contributor.authorHU, LM-
dc.contributor.authorCHANG, GC-
dc.contributor.authorCHEN, KY-
dc.contributor.authorLIU, LI-
dc.contributor.authorHUANG, MS-
dc.contributor.authorYANG, PC-
dc.contributor.authorCHOI, JE-
dc.contributor.authorLIN, HC-
dc.contributor.authorXU, J-
dc.contributor.authorXIANG, YB-
dc.contributor.authorSEOW, A-
dc.contributor.authorPARK, JY-
dc.contributor.authorCHEN, CH-
dc.contributor.authorKWEON, SS-
dc.contributor.authorCHEN, CJ-
dc.contributor.authorLI, HX-
dc.contributor.authorKANG, CH-
dc.contributor.authorGAO, YT-
dc.contributor.authorWU, C-
dc.contributor.authorLIN, DX-
dc.contributor.authorQIAN, BY-
dc.date.accessioned2017-05-22T09:19:16Z-
dc.date.available2017-05-22T09:19:16Z-
dc.date.issued2017-
dc.identifier.citationHuman Molecular Genetics, 2017, v. 26 n. 2, p. 454-465-
dc.identifier.issn0964-6906-
dc.identifier.urihttp://hdl.handle.net/10722/240908-
dc.descriptionLink to Free access-
dc.description.abstractTo evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/-
dc.relation.ispartofHuman Molecular Genetics-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleAssociation between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations-
dc.typeArticle-
dc.identifier.emailZheng, H: zhengh42@hku.hk-
dc.identifier.emailLee, VHF: vhflee@hku.hk-
dc.identifier.authorityLee, VHF=rp00264-
dc.identifier.doi10.1093/hmg/ddw414-
dc.identifier.pmid28025329-
dc.identifier.pmcidPMC5856088-
dc.identifier.scopuseid_2-s2.0-85018291744-
dc.identifier.hkuros272104-
dc.identifier.hkuros309324-
dc.identifier.volume26-
dc.identifier.issue2-
dc.identifier.spage454-
dc.identifier.epage465-
dc.identifier.isiWOS:000397066400018-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0964-6906-

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