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Conference Paper: Low Volume Deceased Donor Liver Transplantation Alongside Living Donor Liver Transplantation
Title | Low Volume Deceased Donor Liver Transplantation Alongside Living Donor Liver Transplantation |
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Authors | |
Issue Date | 2010 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 |
Citation | International Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S145-S146, abstract no. P92 How to Cite? |
Abstract | Background: Living donor liver transplantation (LDLT) is to date the only realistic lifesaving treatment alternative to deceased donor liver transplantation. With advances in surgical techniques and therapeutics in the last decade, despite the use of a partial graft, which is often small-for-size, LDLT is at least as good as deceased donor liver transplantation (DDLT).
Methods: We looked into the outcomes of DDLT, in low volume, by international standards, alongside a matured LDLT service. Comparison was made between our LDLT and overseas DDLT.
Results: From 1991 to the end of 2007, we performed 185 DDLT (Era I, n=59, Era II, n=126). Era I coincided with the fi rst 50 LDLT in our center and was considered the formative period. All donors were brain-dead and heart-beating with a median age of 47.5 (range, 9 – 76 years). Up to 65.9% of recipients
were hepatitis B carriers. Up to 29.7% were transplanted on high urgency basis and 14.6% for hepatocellular carcinoma. The Model for End-stage Liver Disease score was 21 (range, 6 – 56). Before transplantation, 15.7% were in the intensive care unit and 19.7% in hospital. Hospital mortality
rate dropped from 13.6% (8/59) of Era I to 4.8% (6/126) of Era II (p =0.035). Recipient survival rates of Era I were 84.8%, 79.7%, and 76.3% and increased to 92.9%, 89.6%, and 88.0% at 1, 3, and 5 years (p = 0.0147). Only recipients underwent retransplantation (3.2%) and 1 failed. From Era II, recipient survivals surpassed the average 1- and 5-year survivals of DDLT by international standards.
Conclusion: DDLT alongside LDLT has excellent results despite a small number. |
Description | Poster Session I - Outcomes |
Persistent Identifier | http://hdl.handle.net/10722/241096 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.700 |
DC Field | Value | Language |
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dc.contributor.author | Chan, SC | - |
dc.contributor.author | Lo, CM | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Tsang, SH | - |
dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Sharr, WW | - |
dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Fan, ST | - |
dc.date.accessioned | 2017-05-24T06:39:43Z | - |
dc.date.available | 2017-05-24T06:39:43Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | International Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S145-S146, abstract no. P92 | - |
dc.identifier.issn | 1527-6465 | - |
dc.identifier.uri | http://hdl.handle.net/10722/241096 | - |
dc.description | Poster Session I - Outcomes | - |
dc.description.abstract | Background: Living donor liver transplantation (LDLT) is to date the only realistic lifesaving treatment alternative to deceased donor liver transplantation. With advances in surgical techniques and therapeutics in the last decade, despite the use of a partial graft, which is often small-for-size, LDLT is at least as good as deceased donor liver transplantation (DDLT). Methods: We looked into the outcomes of DDLT, in low volume, by international standards, alongside a matured LDLT service. Comparison was made between our LDLT and overseas DDLT. Results: From 1991 to the end of 2007, we performed 185 DDLT (Era I, n=59, Era II, n=126). Era I coincided with the fi rst 50 LDLT in our center and was considered the formative period. All donors were brain-dead and heart-beating with a median age of 47.5 (range, 9 – 76 years). Up to 65.9% of recipients were hepatitis B carriers. Up to 29.7% were transplanted on high urgency basis and 14.6% for hepatocellular carcinoma. The Model for End-stage Liver Disease score was 21 (range, 6 – 56). Before transplantation, 15.7% were in the intensive care unit and 19.7% in hospital. Hospital mortality rate dropped from 13.6% (8/59) of Era I to 4.8% (6/126) of Era II (p =0.035). Recipient survival rates of Era I were 84.8%, 79.7%, and 76.3% and increased to 92.9%, 89.6%, and 88.0% at 1, 3, and 5 years (p = 0.0147). Only recipients underwent retransplantation (3.2%) and 1 failed. From Era II, recipient survivals surpassed the average 1- and 5-year survivals of DDLT by international standards. Conclusion: DDLT alongside LDLT has excellent results despite a small number. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 | - |
dc.relation.ispartof | Liver Transplantation | - |
dc.rights | Liver Transplantation. Copyright © John Wiley & Sons, Inc. | - |
dc.title | Low Volume Deceased Donor Liver Transplantation Alongside Living Donor Liver Transplantation | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, SC: chanlsc@hkucc.hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | - |
dc.identifier.email | Sharr, WW: wwsharr@hku.hk | - |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | - |
dc.identifier.email | Fan, ST: stfan@hku.hk | - |
dc.identifier.authority | Chan, SC=rp01568 | - |
dc.identifier.authority | Lo, CM=rp00412 | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.identifier.authority | Cheung, TT=rp02129 | - |
dc.identifier.authority | Chok, KSH=rp02110 | - |
dc.identifier.authority | Fan, ST=rp00355 | - |
dc.identifier.doi | 10.1002/lt.22086 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | Suppl. 1 | - |
dc.identifier.spage | S145 | - |
dc.identifier.epage | S146 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1527-6465 | - |