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Conference Paper: Accurate Prediction of Milan Criteria: The Role of Dual Tracer 18F-FDG and 11C-Acetate PET-CT Scan.
Title | Accurate Prediction of Milan Criteria: The Role of Dual Tracer 18F-FDG and 11C-Acetate PET-CT Scan. |
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Authors | |
Issue Date | 2010 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 |
Citation | International Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S69, abstract no. O-3 How to Cite? |
Abstract | Background: Since CT scan has been notorious for its low sensitivity for small HCC, it gave a poor predict of Milan criteria before liver transplantation.The objective of this study is to evaluate whether dual tracer PET CT is a more sensitive and accurate tumour staging method.
Method: Between January 2004 and September 2009, we retrospectively reviewed fi fty-eight patients who had dual tracer whole body PET scan before operation. In this group of patients, 30 patients underwent hepatectomy and 28 underwent liver transplantation. All patients were found to have HCC
proven by pathological assessment. The result of HCC staging and Milan criteria according to CT scan, 18F-FDG PET, 18F-FDG and 11C-acetate PET CT were compared with the pathological result after operation.
Results: In this study, the sensitivity of 18F-FDG PET, CT scan, 18F-FDG and 11C-acetate PET CT were 60%, 62% and 96% respectively. 25 patients had HCC inside Milan criteria and 33 patients had HCC out of Milan criteria. Using CT scan alone, the prediction for within and outside pathological Milan
criteria was 52% and 70% (P=1). Using 18F-FDG PET alone, the prediction for within and outside pathological Milan criteria was 56% and 63% (P=0.538). Using 18F-FDG and 11C-acetate PET CT, the prediction for within and outside pathological Milan criteria was 100% and 93% (P=1). Using 18F-FDG PET alone, 35 patients were found defi nitive for HCC, only15 patients had a same tumour staging when compared with the fi nal pathology (p=0.048). Using CT scan alone, 36 patients were found defi nitive for HCC, only 9 patients had a same tumour staging (p=0.024). Using 18F-FDG and 11C-acetate PET CT, 56 patients were found defi nitive for HCC, and 41 patients had a same tumour staging (p=0.262). 5 patients had additional pathology detected by dual tracer PET CT.
Conclusion: 18F-FDG and 11C-acetate PET CT provide better prediction for Milan criteria and tumour staging at pathological examination when compared to CT scan alone. It is a good revaluation method for patient selection before liver transplantation |
Description | Plenary Session I |
Persistent Identifier | http://hdl.handle.net/10722/241098 |
ISSN | 2021 Impact Factor: 6.112 2020 SCImago Journal Rankings: 1.814 |
DC Field | Value | Language |
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dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Chan, SC | - |
dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Ng, KKC | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Sharr, WW | - |
dc.contributor.author | Poon, RTP | - |
dc.contributor.author | Lo, CM | - |
dc.contributor.author | Fan, ST | - |
dc.date.accessioned | 2017-05-24T07:22:53Z | - |
dc.date.available | 2017-05-24T07:22:53Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | International Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S69, abstract no. O-3 | - |
dc.identifier.issn | 1527-6465 | - |
dc.identifier.uri | http://hdl.handle.net/10722/241098 | - |
dc.description | Plenary Session I | - |
dc.description.abstract | Background: Since CT scan has been notorious for its low sensitivity for small HCC, it gave a poor predict of Milan criteria before liver transplantation.The objective of this study is to evaluate whether dual tracer PET CT is a more sensitive and accurate tumour staging method. Method: Between January 2004 and September 2009, we retrospectively reviewed fi fty-eight patients who had dual tracer whole body PET scan before operation. In this group of patients, 30 patients underwent hepatectomy and 28 underwent liver transplantation. All patients were found to have HCC proven by pathological assessment. The result of HCC staging and Milan criteria according to CT scan, 18F-FDG PET, 18F-FDG and 11C-acetate PET CT were compared with the pathological result after operation. Results: In this study, the sensitivity of 18F-FDG PET, CT scan, 18F-FDG and 11C-acetate PET CT were 60%, 62% and 96% respectively. 25 patients had HCC inside Milan criteria and 33 patients had HCC out of Milan criteria. Using CT scan alone, the prediction for within and outside pathological Milan criteria was 52% and 70% (P=1). Using 18F-FDG PET alone, the prediction for within and outside pathological Milan criteria was 56% and 63% (P=0.538). Using 18F-FDG and 11C-acetate PET CT, the prediction for within and outside pathological Milan criteria was 100% and 93% (P=1). Using 18F-FDG PET alone, 35 patients were found defi nitive for HCC, only15 patients had a same tumour staging when compared with the fi nal pathology (p=0.048). Using CT scan alone, 36 patients were found defi nitive for HCC, only 9 patients had a same tumour staging (p=0.024). Using 18F-FDG and 11C-acetate PET CT, 56 patients were found defi nitive for HCC, and 41 patients had a same tumour staging (p=0.262). 5 patients had additional pathology detected by dual tracer PET CT. Conclusion: 18F-FDG and 11C-acetate PET CT provide better prediction for Milan criteria and tumour staging at pathological examination when compared to CT scan alone. It is a good revaluation method for patient selection before liver transplantation | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 | - |
dc.relation.ispartof | Liver Transplantation | - |
dc.rights | Liver Transplantation. Copyright © John Wiley & Sons, Inc. | - |
dc.title | Accurate Prediction of Milan Criteria: The Role of Dual Tracer 18F-FDG and 11C-Acetate PET-CT Scan. | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | - |
dc.identifier.email | Chan, SC: chanlsc@hkucc.hku.hk | - |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.email | Sharr, WW: wwsharr@hku.hk | - |
dc.identifier.email | Poon, RTP: poontp@hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
dc.identifier.email | Fan, ST: stfan@hku.hk | - |
dc.identifier.authority | Cheung, TT=rp02129 | - |
dc.identifier.authority | Chan, SC=rp01568 | - |
dc.identifier.authority | Chok, KSH=rp02110 | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.identifier.authority | Poon, RTP=rp00446 | - |
dc.identifier.authority | Lo, CM=rp00412 | - |
dc.identifier.authority | Fan, ST=rp00355 | - |
dc.identifier.doi | 10.1002/lt.22086 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | Suppl. 1 | - |
dc.identifier.spage | S69 | - |
dc.identifier.epage | S69 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1527-6465 | - |