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Conference Paper: Long-term analysis of a prospective randomized trial of hepatic resection versus radiofrequency ablation for early stage hepatocellular carcinoma
Title | Long-term analysis of a prospective randomized trial of hepatic resection versus radiofrequency ablation for early stage hepatocellular carcinoma |
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Authors | |
Issue Date | 2017 |
Publisher | Wiley. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1868-6982 |
Citation | Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association & The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery, Yokohama, Japan, 7–10 June 2017. In Journal of Hepato-Biliary-Pancreatic Sciences, 2017, v. 24 n. S1, p. A88, abstract no. PL-3 How to Cite? |
Abstract | Background: Both hepatic resection (HR) and radiofrequency ablation (RFA) are treatment of choice for early stage hepatocellular carcinoma (HCC). This prospective randomized study aims to test the hypothesis that RFA is superior than HR in terms of reduced tumor recurrence and better long–term survival.
Methods: Two hundreds and eighteen patients with early stage HCC (tumor size ≤ 5cm and tumor nodules ≤ 3) were randomized into HR group (n = 109) and RFA group (n = 109). Primary and secondary
outcome measure was overall tumor recurrence and patientsʼsurvival, respectively.
Results: RFA group had significantly shorter treatment duration, less blood loss and shorted hospital stay when compared with HR group. The 1–year, 3–year, 5–year and 10–year overall survival rates for HR
group and RFA group were 94.5%, 80.6%, 66.5%, 47.6% and 95.4%, 82.3%, 66.4%, 41.8%, respectively. Meanwhile, the 1–year, 3–year, 5–year and 10–year disease–free survival rates for HR group and RFA
groups were 74.1%, 50.9%, 41.5%, 31.9% and 70.6%, 46.6%, 33.6%, 18. 6%, respectively. No statistical significant difference was found between 2 groups in overall and disease–free survival.
Conclusion: Both HR and RFA are effective treatment modalities for early stage HCC in terms of similar overall survival and disease–free survival rates. |
Description | Plenary Oral – Best of the Best Presentation |
Persistent Identifier | http://hdl.handle.net/10722/243421 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.045 |
DC Field | Value | Language |
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dc.contributor.author | Ng, KCK | - |
dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Wong, TCL | - |
dc.contributor.author | Lo, CM | - |
dc.date.accessioned | 2017-08-25T02:54:36Z | - |
dc.date.available | 2017-08-25T02:54:36Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association & The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery, Yokohama, Japan, 7–10 June 2017. In Journal of Hepato-Biliary-Pancreatic Sciences, 2017, v. 24 n. S1, p. A88, abstract no. PL-3 | - |
dc.identifier.issn | 1868-6974 | - |
dc.identifier.uri | http://hdl.handle.net/10722/243421 | - |
dc.description | Plenary Oral – Best of the Best Presentation | - |
dc.description.abstract | Background: Both hepatic resection (HR) and radiofrequency ablation (RFA) are treatment of choice for early stage hepatocellular carcinoma (HCC). This prospective randomized study aims to test the hypothesis that RFA is superior than HR in terms of reduced tumor recurrence and better long–term survival. Methods: Two hundreds and eighteen patients with early stage HCC (tumor size ≤ 5cm and tumor nodules ≤ 3) were randomized into HR group (n = 109) and RFA group (n = 109). Primary and secondary outcome measure was overall tumor recurrence and patientsʼsurvival, respectively. Results: RFA group had significantly shorter treatment duration, less blood loss and shorted hospital stay when compared with HR group. The 1–year, 3–year, 5–year and 10–year overall survival rates for HR group and RFA group were 94.5%, 80.6%, 66.5%, 47.6% and 95.4%, 82.3%, 66.4%, 41.8%, respectively. Meanwhile, the 1–year, 3–year, 5–year and 10–year disease–free survival rates for HR group and RFA groups were 74.1%, 50.9%, 41.5%, 31.9% and 70.6%, 46.6%, 33.6%, 18. 6%, respectively. No statistical significant difference was found between 2 groups in overall and disease–free survival. Conclusion: Both HR and RFA are effective treatment modalities for early stage HCC in terms of similar overall survival and disease–free survival rates. | - |
dc.language | eng | - |
dc.publisher | Wiley. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1868-6982 | - |
dc.relation.ispartof | Journal of Hepato-Biliary-Pancreatic Sciences | - |
dc.title | Long-term analysis of a prospective randomized trial of hepatic resection versus radiofrequency ablation for early stage hepatocellular carcinoma | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Ng, KCK: kkcng@hku.hk | - |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | - |
dc.identifier.email | Wong, TCL: wongtcl@hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hku.hk | - |
dc.identifier.authority | Chok, KSH=rp02110 | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.identifier.authority | Cheung, TT=rp02129 | - |
dc.identifier.authority | Wong, TCL=rp01679 | - |
dc.identifier.authority | Lo, CM=rp00412 | - |
dc.identifier.doi | 10.1002/jhbp.475 | - |
dc.identifier.hkuros | 275128 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | S1 | - |
dc.identifier.spage | A88 | - |
dc.identifier.epage | A88 | - |
dc.publisher.place | Japan | - |
dc.identifier.issnl | 1868-6974 | - |