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- Publisher Website: 10.7554/eLife.26733
- Scopus: eid_2-s2.0-85029187084
- PMID: 28737489
- WOS: WOS:000408333900001
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Article: Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma
Title | Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma |
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Authors | |
Issue Date | 2017 |
Publisher | eLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/ |
Citation | eLife, 2017, v. 6, p. e26733 How to Cite? |
Abstract | Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high NFATc2 expression predicted poor tumor differentiation, adverse recurrence-free and cancer-specific overall survivals. Mechanistic investigations identified NFATc2 response elements in the 3' enhancer region of SOX2, and NFATc2/SOX2 coupling upregulates ALDH1A1 by binding to its 5' enhancer. Through this axis, oxidative stress induced by cancer drug treatment is attenuated, leading to increased resistance in a mutation-independent manner. Targeting this axis provides a novel approach for the long-term treatment of lung cancer through TIC elimination. |
Persistent Identifier | http://hdl.handle.net/10722/247669 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.932 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xiao, Z | - |
dc.contributor.author | Liu, J | - |
dc.contributor.author | WANG, S | - |
dc.contributor.author | ZHU, Y | - |
dc.contributor.author | GAO, X | - |
dc.contributor.author | Qin, J | - |
dc.contributor.author | Wang, J | - |
dc.contributor.author | Wong, MP | - |
dc.date.accessioned | 2017-10-18T08:30:45Z | - |
dc.date.available | 2017-10-18T08:30:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | eLife, 2017, v. 6, p. e26733 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10722/247669 | - |
dc.description.abstract | Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high NFATc2 expression predicted poor tumor differentiation, adverse recurrence-free and cancer-specific overall survivals. Mechanistic investigations identified NFATc2 response elements in the 3' enhancer region of SOX2, and NFATc2/SOX2 coupling upregulates ALDH1A1 by binding to its 5' enhancer. Through this axis, oxidative stress induced by cancer drug treatment is attenuated, leading to increased resistance in a mutation-independent manner. Targeting this axis provides a novel approach for the long-term treatment of lung cancer through TIC elimination. | - |
dc.language | eng | - |
dc.publisher | eLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/ | - |
dc.relation.ispartof | eLife | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Nfatc2 Enhances Tumor-initiating Phenotypes Through The Nfatc2/sox2/aldh Axis In Lung Adenocarcinoma | - |
dc.type | Article | - |
dc.identifier.email | Xiao, Z: xiaozj@hku.hk | - |
dc.identifier.email | Liu, J: jingliue@hku.hk | - |
dc.identifier.email | Wong, MP: mwpik@hku.hk | - |
dc.identifier.authority | Wong, MP=rp00348 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.7554/eLife.26733 | - |
dc.identifier.pmid | 28737489 | - |
dc.identifier.pmcid | PMC5570574 | - |
dc.identifier.scopus | eid_2-s2.0-85029187084 | - |
dc.identifier.hkuros | 280919 | - |
dc.identifier.volume | 6 | - |
dc.identifier.spage | e26733 | - |
dc.identifier.epage | e26733 | - |
dc.identifier.isi | WOS:000408333900001 | - |
dc.publisher.place | Cambridge, UK | - |
dc.identifier.issnl | 2050-084X | - |