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Conference Paper: Optogenetic Resting-State FMRI Reveals Thalamic Modulation of Long-Range Sensory Networks.

TitleOptogenetic Resting-State FMRI Reveals Thalamic Modulation of Long-Range Sensory Networks.
Authors
Leong, ATLWang, XChan, RWHo, CCQiu, YDong, CMWu, EX
Issue Date2017
PublisherThe International Society for Magnetic Resonance in Medicine.
Citation
The International Society of Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition, Honolulu, HI, USA, 22-27 April 2017 How to Cite?
AbstractOne grand challenge in contemporary neuroscience is to achieve an integrated understanding of large-scale brain-wide networks. Resting-state functional MRI (rsfMRI) has helped reveal such brain-wide networks, yet, the neural bases underlying them remain unclear. Utilizing optogenetic excitation and pharmacological inactivation to manipulate the neural activity of somatosensory thalamocortical neurons, the present study demonstrated that rsfMRI connectivity is enhanced and decreased respectively. Furthermore, our findings suggest that optogenetically-evoked propagating low frequency activity (~1Hz) within the thalamo-cortico-thalamic network facilitate the enhancement of rsfMRI connectivity. Our work offers an exciting avenue to dissect the underlying neural bases of brain-wide functional connectivity.
DescriptionPower Pitch Session: Cutting Edge fMRI - abstract no. 0239
Persistent Identifierhttp://hdl.handle.net/10722/247804

 

DC FieldValueLanguage
dc.contributor.authorLeong, ATL-
dc.contributor.authorWang, X-
dc.contributor.authorChan, RW-
dc.contributor.authorHo, CC-
dc.contributor.authorQiu, Y-
dc.contributor.authorDong, CM-
dc.contributor.authorWu, EX-
dc.date.accessioned2017-10-18T08:32:55Z-
dc.date.available2017-10-18T08:32:55Z-
dc.date.issued2017-
dc.identifier.citationThe International Society of Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition, Honolulu, HI, USA, 22-27 April 2017-
dc.identifier.urihttp://hdl.handle.net/10722/247804-
dc.descriptionPower Pitch Session: Cutting Edge fMRI - abstract no. 0239-
dc.description.abstractOne grand challenge in contemporary neuroscience is to achieve an integrated understanding of large-scale brain-wide networks. Resting-state functional MRI (rsfMRI) has helped reveal such brain-wide networks, yet, the neural bases underlying them remain unclear. Utilizing optogenetic excitation and pharmacological inactivation to manipulate the neural activity of somatosensory thalamocortical neurons, the present study demonstrated that rsfMRI connectivity is enhanced and decreased respectively. Furthermore, our findings suggest that optogenetically-evoked propagating low frequency activity (~1Hz) within the thalamo-cortico-thalamic network facilitate the enhancement of rsfMRI connectivity. Our work offers an exciting avenue to dissect the underlying neural bases of brain-wide functional connectivity.-
dc.languageeng-
dc.publisherThe International Society for Magnetic Resonance in Medicine. -
dc.relation.ispartofISMRM 2017 Annual Meeting & Exhibition-
dc.titleOptogenetic Resting-State FMRI Reveals Thalamic Modulation of Long-Range Sensory Networks. -
dc.typeConference_Paper-
dc.identifier.emailChan, RW: russchan@connect.hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193-
dc.identifier.hkuros280424-
dc.publisher.placeUnited States-

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