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- Publisher Website: 10.1016/j.transproceed.2018.01.025
- Scopus: eid_2-s2.0-85046693736
- PMID: 29731072
- WOS: WOS:000431940700026
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Conference Paper: Changing Paradigm in the Surgical Management of Hepatocellular Carcinoma With Salvage Transplantation
Title | Changing Paradigm in the Surgical Management of Hepatocellular Carcinoma With Salvage Transplantation |
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Authors | |
Issue Date | 2018 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/transproceed |
Citation | Asian Transplantation Week 2017, Incheon, Korea, 18-22 October 2017. In Transplantation Proceedings, v. 50 n. 4, p. 1087-1093 How to Cite? |
Abstract | Objective: The objective of this study was to compare the long-term outcomes of primary and salvage liver transplantation for patients with hepatocellular carcinoma (HCC). Method: This was a 10-year retrospective analysis in a tertiary referral center. Results: There were 184 patients recruited (primary liver transplantation [pLT]:salvage liver transplantation [sLT], 143:41). The median follow-up time was 79 months. Operation time was shorter in the pLT group than the sLT group (661 ± 164 minutes vs 754 ± 206 minutes; P =.01) and the blood loss was 3749 mL and 3545 mL for pLT and sLT, respectively (P =.735). The reoperation rate was 5.6% and 4.9%, respectively (P = 1.0). The 5-year overall and disease-free survival rates from the time of transplantation for pLT and sLT were 84.1% versus 70.2% (P =.01) and 82.2% versus 65.8% (P =.01), respectively. The 5-year overall survival rate from the time of primary treatment for sLT was 80.3% (P =.1). Subgroup analysis of sLT showed that young age (50 vs 56 year old; P =.004) was the only factor associated with poor overall survival. Young age (P =.004) and microvascular permeation (P =.008) in the recurrent tumor were associated with HCC recurrence. Young age stands out to be the only independent factor associated with HCC recurrence. Conclusion: sLT is the treatment of choice for patients with recurrent HCC in regions of graft shortage. |
Persistent Identifier | http://hdl.handle.net/10722/259376 |
ISSN | 2023 Impact Factor: 0.8 2023 SCImago Journal Rankings: 0.318 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ma, KW | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | She, WH | - |
dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Dai, WC | - |
dc.contributor.author | Fung, JYY | - |
dc.contributor.author | Lo, CM | - |
dc.date.accessioned | 2018-09-03T04:06:22Z | - |
dc.date.available | 2018-09-03T04:06:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Asian Transplantation Week 2017, Incheon, Korea, 18-22 October 2017. In Transplantation Proceedings, v. 50 n. 4, p. 1087-1093 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | http://hdl.handle.net/10722/259376 | - |
dc.description.abstract | Objective: The objective of this study was to compare the long-term outcomes of primary and salvage liver transplantation for patients with hepatocellular carcinoma (HCC). Method: This was a 10-year retrospective analysis in a tertiary referral center. Results: There were 184 patients recruited (primary liver transplantation [pLT]:salvage liver transplantation [sLT], 143:41). The median follow-up time was 79 months. Operation time was shorter in the pLT group than the sLT group (661 ± 164 minutes vs 754 ± 206 minutes; P =.01) and the blood loss was 3749 mL and 3545 mL for pLT and sLT, respectively (P =.735). The reoperation rate was 5.6% and 4.9%, respectively (P = 1.0). The 5-year overall and disease-free survival rates from the time of transplantation for pLT and sLT were 84.1% versus 70.2% (P =.01) and 82.2% versus 65.8% (P =.01), respectively. The 5-year overall survival rate from the time of primary treatment for sLT was 80.3% (P =.1). Subgroup analysis of sLT showed that young age (50 vs 56 year old; P =.004) was the only factor associated with poor overall survival. Young age (P =.004) and microvascular permeation (P =.008) in the recurrent tumor were associated with HCC recurrence. Young age stands out to be the only independent factor associated with HCC recurrence. Conclusion: sLT is the treatment of choice for patients with recurrent HCC in regions of graft shortage. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/transproceed | - |
dc.relation.ispartof | Transplantation Proceedings | - |
dc.title | Changing Paradigm in the Surgical Management of Hepatocellular Carcinoma With Salvage Transplantation | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.email | She, WH: brianshe@hku.hk | - |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | - |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | - |
dc.identifier.email | Dai, WC: daiwc@HKUCC-COM.hku.hk | - |
dc.identifier.email | Fung, JYY: jfung@hkucc.hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.identifier.authority | Chok, KSH=rp02110 | - |
dc.identifier.authority | Cheung, TT=rp02129 | - |
dc.identifier.authority | Fung, JYY=rp00518 | - |
dc.identifier.authority | Lo, CM=rp00412 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.transproceed.2018.01.025 | - |
dc.identifier.pmid | 29731072 | - |
dc.identifier.scopus | eid_2-s2.0-85046693736 | - |
dc.identifier.hkuros | 288587 | - |
dc.identifier.volume | 50 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1087 | - |
dc.identifier.epage | 1093 | - |
dc.identifier.isi | WOS:000431940700026 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0041-1345 | - |