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- Publisher Website: 10.1007/s12072-017-9821-2
- Scopus: eid_2-s2.0-85029716129
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Article: Comparable short- and long-term outcomes in deceased-donor and living-donor liver retransplantation
Title | Comparable short- and long-term outcomes in deceased-donor and living-donor liver retransplantation |
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Authors | |
Keywords | Biliary complications Deceased-donor liver re-transplantation Graft failure Hepatic artery thrombosis Living-donor liver re-transplantation |
Issue Date | 2017 |
Publisher | Springer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0 |
Citation | Hepatology International, 2017, v. 11 n. 6, p. 517-522 How to Cite? |
Abstract | Background and purpose: There is a big controversy over liver retransplantation, the only life-saving treatment for patients with a failing or failed liver graft. This retrospective study tried to determine if living-donor liver retransplantation (re-LDLT) is a justifiable alternative to deceased-donor liver retransplantation (re-DDLT). Methods: Anonymous data of liver transplant patients from January 2000 to April 2016 were reviewed. Recipients of retransplantation were divided into the re-DDLT and re-LDLT groups. The groups were compared in demographic characteristics, pre-retransplant and intraoperative details, and short- and long-term outcomes. Risk for living donors was examined. Results: Twenty-nine patients had 33 re-DDLTs and 15 patients received re-LDLT. The re-LDLT group had lighter grafts (525 vs. 1295 g, p ≤ 0.001), a smaller ratio of graft weight to recipient standard liver volume (56.98 vs. 107.7%, p ≤ 0.001), and shorter cold ischemia (106 vs. 451 min, p ≤ 0.001). The groups were otherwise comparable. Two patients in the re-DDLT group had Grade-5 complication. The groups were similar in patient survival (p = 0.326) and graft survival (p = 0.102). No living donors died, but three of them developed Grade-1 complications. Conclusion: With the required expertise, re-LDLT can produce results comparable to those of re-DDLT while keeping donor risk at bay. In places where the demand for deceased-donor liver grafts far outstrips supply, re-LDLT can be considered as an alternative to re-DDLT if the expertise is available and if the potential recipient benefits can balance out the potential donor risks. |
Persistent Identifier | http://hdl.handle.net/10722/259379 |
ISSN | 2023 Impact Factor: 5.9 2023 SCImago Journal Rankings: 1.813 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Fung, JYY | - |
dc.contributor.author | Dai, WC | - |
dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Lo, CM | - |
dc.date.accessioned | 2018-09-03T04:06:27Z | - |
dc.date.available | 2018-09-03T04:06:27Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Hepatology International, 2017, v. 11 n. 6, p. 517-522 | - |
dc.identifier.issn | 1936-0533 | - |
dc.identifier.uri | http://hdl.handle.net/10722/259379 | - |
dc.description.abstract | Background and purpose: There is a big controversy over liver retransplantation, the only life-saving treatment for patients with a failing or failed liver graft. This retrospective study tried to determine if living-donor liver retransplantation (re-LDLT) is a justifiable alternative to deceased-donor liver retransplantation (re-DDLT). Methods: Anonymous data of liver transplant patients from January 2000 to April 2016 were reviewed. Recipients of retransplantation were divided into the re-DDLT and re-LDLT groups. The groups were compared in demographic characteristics, pre-retransplant and intraoperative details, and short- and long-term outcomes. Risk for living donors was examined. Results: Twenty-nine patients had 33 re-DDLTs and 15 patients received re-LDLT. The re-LDLT group had lighter grafts (525 vs. 1295 g, p ≤ 0.001), a smaller ratio of graft weight to recipient standard liver volume (56.98 vs. 107.7%, p ≤ 0.001), and shorter cold ischemia (106 vs. 451 min, p ≤ 0.001). The groups were otherwise comparable. Two patients in the re-DDLT group had Grade-5 complication. The groups were similar in patient survival (p = 0.326) and graft survival (p = 0.102). No living donors died, but three of them developed Grade-1 complications. Conclusion: With the required expertise, re-LDLT can produce results comparable to those of re-DDLT while keeping donor risk at bay. In places where the demand for deceased-donor liver grafts far outstrips supply, re-LDLT can be considered as an alternative to re-DDLT if the expertise is available and if the potential recipient benefits can balance out the potential donor risks. | - |
dc.language | eng | - |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0 | - |
dc.relation.ispartof | Hepatology International | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/[insert DOI] | - |
dc.subject | Biliary complications | - |
dc.subject | Deceased-donor liver re-transplantation | - |
dc.subject | Graft failure | - |
dc.subject | Hepatic artery thrombosis | - |
dc.subject | Living-donor liver re-transplantation | - |
dc.title | Comparable short- and long-term outcomes in deceased-donor and living-donor liver retransplantation | - |
dc.type | Article | - |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | - |
dc.identifier.email | Chan, ACY: acchan@hku.hk | - |
dc.identifier.email | Fung, JYY: jfung@hkucc.hku.hk | - |
dc.identifier.email | Dai, WC: daiwc@HKUCC-COM.hku.hk | - |
dc.identifier.email | Cheung, TT: cheung68@hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
dc.identifier.authority | Chok, KSH=rp02110 | - |
dc.identifier.authority | Chan, ACY=rp00310 | - |
dc.identifier.authority | Fung, JYY=rp00518 | - |
dc.identifier.authority | Cheung, TT=rp02129 | - |
dc.identifier.authority | Lo, CM=rp00412 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s12072-017-9821-2 | - |
dc.identifier.scopus | eid_2-s2.0-85029716129 | - |
dc.identifier.hkuros | 288607 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 517 | - |
dc.identifier.epage | 522 | - |
dc.identifier.isi | WOS:000416341100007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1936-0533 | - |