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Conference Paper: RISKY DECISION-MAKING PERFORMANCE IN PATIENTS WITH EARLY SCHIZOPHRENIA-SPECTRUM DISORDER
Title | RISKY DECISION-MAKING PERFORMANCE IN PATIENTS WITH EARLY SCHIZOPHRENIA-SPECTRUM DISORDER |
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Authors | |
Issue Date | 2018 |
Publisher | Oxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/ |
Citation | The Sixth Biennial Schizophrenia International Research Society (SIRS) Conference, Florence, Italy, 4-8 April 2018. Abstracts in Schizophrenia Bulletin, 2018, v. 44 n. s1, p. S243-S244 How to Cite? |
Abstract | Background: Dysfunction in risky decision-making has been regarded as one potential contributing factor to functional impairment exhibited in patients with schizophrenia. Literature has revealed suboptimal risky decision-making in chronic schizophrenia patients. However, abnormality in risky decision-making has not been investigated in the early stage of illness. This study aimed to examine whether early schizophrenia patients displayed aberrant risky decision-making using two well-validated paradigms including Balloon Analogue Risk Task (BART; Lejuez et al., 2002) and Risky-Gains Task (RGT; Paulus et al., 2003).
Methods: Thirty-three clinically-stable patients diagnosed with DSM-V schizophrenia-spectrum disorder (including schizophrenia, schizoaffective disorder or schizophreniform disorder) were recruited from specialized early intervention service for psychosis in Hong Kong. A group of healthy controls (n=32), matched with age, gender and educational levels, was enrolled for comparison. All participants were evaluated with a brief battery of cognitive assessment and two computerized risky decision-making tasks. Symptom assessment was also conducted for patients.
Results: In both BART and RGT, patients with early schizophrenia-spectrum disorder performed worse than healthy controls regarding total points gained and reaction time. In BART, patients had significantly lower adjusted scores (F(1,63)=7.8, p<0.05) and lower balloon exploration rates than controls (F(1,63)=11.5, p<0.001), indicating that patients exhibited a tendency toward risk-aversion. In GRT, three-way analysis of variance revealed significant group x response interaction (F(1,63)=7.8, p<0.05), with post-hoc independent t-test showing that patients significantly preferred safe over risky options than controls (t=2.6, p<0.05). There were no significant correlations of risky decision-making parameters with symptom ratings and cognitive functions.
Discussion: We extend previous findings of chronic samples to patients with early schizophrenia-spectrum disorder and indicate that suboptimal risky decision-making with risk-aversion preference has also been observed in the early course of illness. Further research is warranted to clarify the longitudinal change of aberrant risk-aversive behavioral patterns and its relationship with prospective functional and symptom outcomes. |
Description | Poster Session II - no. F62 |
Persistent Identifier | http://hdl.handle.net/10722/260805 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 2.249 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Luk, SK | - |
dc.contributor.author | Lee, TMC | - |
dc.contributor.author | Chen, EYH | - |
dc.contributor.author | Chang, WC | - |
dc.date.accessioned | 2018-09-14T08:47:45Z | - |
dc.date.available | 2018-09-14T08:47:45Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | The Sixth Biennial Schizophrenia International Research Society (SIRS) Conference, Florence, Italy, 4-8 April 2018. Abstracts in Schizophrenia Bulletin, 2018, v. 44 n. s1, p. S243-S244 | - |
dc.identifier.issn | 0586-7614 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260805 | - |
dc.description | Poster Session II - no. F62 | - |
dc.description.abstract | Background: Dysfunction in risky decision-making has been regarded as one potential contributing factor to functional impairment exhibited in patients with schizophrenia. Literature has revealed suboptimal risky decision-making in chronic schizophrenia patients. However, abnormality in risky decision-making has not been investigated in the early stage of illness. This study aimed to examine whether early schizophrenia patients displayed aberrant risky decision-making using two well-validated paradigms including Balloon Analogue Risk Task (BART; Lejuez et al., 2002) and Risky-Gains Task (RGT; Paulus et al., 2003). Methods: Thirty-three clinically-stable patients diagnosed with DSM-V schizophrenia-spectrum disorder (including schizophrenia, schizoaffective disorder or schizophreniform disorder) were recruited from specialized early intervention service for psychosis in Hong Kong. A group of healthy controls (n=32), matched with age, gender and educational levels, was enrolled for comparison. All participants were evaluated with a brief battery of cognitive assessment and two computerized risky decision-making tasks. Symptom assessment was also conducted for patients. Results: In both BART and RGT, patients with early schizophrenia-spectrum disorder performed worse than healthy controls regarding total points gained and reaction time. In BART, patients had significantly lower adjusted scores (F(1,63)=7.8, p<0.05) and lower balloon exploration rates than controls (F(1,63)=11.5, p<0.001), indicating that patients exhibited a tendency toward risk-aversion. In GRT, three-way analysis of variance revealed significant group x response interaction (F(1,63)=7.8, p<0.05), with post-hoc independent t-test showing that patients significantly preferred safe over risky options than controls (t=2.6, p<0.05). There were no significant correlations of risky decision-making parameters with symptom ratings and cognitive functions. Discussion: We extend previous findings of chronic samples to patients with early schizophrenia-spectrum disorder and indicate that suboptimal risky decision-making with risk-aversion preference has also been observed in the early course of illness. Further research is warranted to clarify the longitudinal change of aberrant risk-aversive behavioral patterns and its relationship with prospective functional and symptom outcomes. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/ | - |
dc.relation.ispartof | Schizophrenia Bulletin | - |
dc.relation.ispartof | 6th Schizophrenia International Research Society Conference | - |
dc.title | RISKY DECISION-MAKING PERFORMANCE IN PATIENTS WITH EARLY SCHIZOPHRENIA-SPECTRUM DISORDER | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lee, TMC: tmclee@hku.hk | - |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | - |
dc.identifier.email | Chang, WC: changwc@hku.hk | - |
dc.identifier.authority | Lee, TMC=rp00564 | - |
dc.identifier.authority | Chen, EYH=rp00392 | - |
dc.identifier.authority | Chang, WC=rp01465 | - |
dc.identifier.doi | 10.1093/schbul/sby017.593 | - |
dc.identifier.hkuros | 291394 | - |
dc.identifier.volume | 44 | - |
dc.identifier.issue | s1 | - |
dc.identifier.spage | S243 | - |
dc.identifier.epage | S244 | - |
dc.identifier.isi | WOS:000429541800588 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0586-7614 | - |