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Conference Paper: Balance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation

TitleBalance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation
Authors
Chan, YSJiang, QFLai, SKWu, LKMa, CWShum, DKY
Issue Date2017
PublisherThe Japan Society for Neuroscience
Citation
60th Annual Meeting of Japan Society for Neurochemistry, Sendai, Japan, 7-9 September 2017. In Bulletin of the Japanese Society for Neurochemistry, 2017, v. 56 n. 2, p. 119, abstract no. 1S4-2 How to Cite?
AbstractActivity-dependent synaptic plasticity plays a key role in the refinement of neural circuits and expression of behaviors during development. It is unclear if synaptic plasticity of excitatory and inhibitory transmission in the developing circuit of the vestibular nucleus impacts on behavioral outcome. We demonstrated that the efficacy of glutamatergic synapses in the vestibular nucleus enabled postnatal emergence of graviceptive reflex in rats. Modulating the pre- and postsynaptic plasticity of GABAergic synapses also shifted the time for postnatal emergence of this behavior. Neonatal perturbation of glutamate or GABA receptor-mediated transmission not only deterred the establishment of internal spatial map in relay stations of the mature vestibular system but also caused lasting deficits in spatial cognition well into adulthood. Taken together, balance of excitatory and inhibitory synapses in the developing vestibular network is critical for orchestrating behavioral presentation of spatial recognition.[HKRGC-GRF 762313, 17131816; NSFC-RCG N_HKU735/14]
DescriptionSymposia: The new aspects of neurotransmitters and receptors in neuropsychiatric disorders
Persistent Identifierhttp://hdl.handle.net/10722/261282

 

DC FieldValueLanguage
dc.contributor.authorChan, YS-
dc.contributor.authorJiang, QF-
dc.contributor.authorLai, SK-
dc.contributor.authorWu, LK-
dc.contributor.authorMa, CW-
dc.contributor.authorShum, DKY-
dc.date.accessioned2018-09-14T08:55:40Z-
dc.date.available2018-09-14T08:55:40Z-
dc.date.issued2017-
dc.identifier.citation60th Annual Meeting of Japan Society for Neurochemistry, Sendai, Japan, 7-9 September 2017. In Bulletin of the Japanese Society for Neurochemistry, 2017, v. 56 n. 2, p. 119, abstract no. 1S4-2-
dc.identifier.urihttp://hdl.handle.net/10722/261282-
dc.descriptionSymposia: The new aspects of neurotransmitters and receptors in neuropsychiatric disorders-
dc.description.abstractActivity-dependent synaptic plasticity plays a key role in the refinement of neural circuits and expression of behaviors during development. It is unclear if synaptic plasticity of excitatory and inhibitory transmission in the developing circuit of the vestibular nucleus impacts on behavioral outcome. We demonstrated that the efficacy of glutamatergic synapses in the vestibular nucleus enabled postnatal emergence of graviceptive reflex in rats. Modulating the pre- and postsynaptic plasticity of GABAergic synapses also shifted the time for postnatal emergence of this behavior. Neonatal perturbation of glutamate or GABA receptor-mediated transmission not only deterred the establishment of internal spatial map in relay stations of the mature vestibular system but also caused lasting deficits in spatial cognition well into adulthood. Taken together, balance of excitatory and inhibitory synapses in the developing vestibular network is critical for orchestrating behavioral presentation of spatial recognition.[HKRGC-GRF 762313, 17131816; NSFC-RCG N_HKU735/14]-
dc.languageeng-
dc.publisherThe Japan Society for Neuroscience-
dc.relation.ispartofBulletin of Japan Soc Neurochemistry-
dc.relation.ispartof60th Annual Meeting of Japan Society for Neurochemistry-
dc.titleBalance of excitatory-inhibitory transmission in the developing vestibular nucleus tunes the brain circuitry for navigation-
dc.typeConference_Paper-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailWu, LK: lwu03@hku.hk-
dc.identifier.emailMa, CW: cwma2010@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.hkuros291389-
dc.identifier.volume56-
dc.identifier.issue2-
dc.identifier.spage119-
dc.identifier.epage119-
dc.publisher.placeJapan-

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