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Conference Paper: Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors

TitleSerotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors
Authors
Chan, YSHan, LLi, YHWu, LKShum, DKY
Issue Date2017
PublisherSociety for Neuroscience. The Journal's web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings
Citation
Society for Neuroscience 2017 Annual Meeting, Washington DC, USA, 11–15 November 2017. In Neuroscience 2017 Abstracts, p. no. 286.23 How to Cite?
AbstractThe medial vestibular nucleus (MVN) is a major relay station for postural coordination, eye movement control and spatial cognition. Microinjection of 5-HT to the MVN impaired performance of vestibular-mediated motor balance and negative geotaxis in both adult and juvenile (P13-16) rats. We hypothesize that serotonergic neurotransmission modulates the activity of neurons in the MVN circuitry for vestibular-related behaviors. Specific activation of 5-HT7 receptors in the MVN restricted circuit plasticity by abolishing NMDAR-mediated LTD via a protein kinase A (PKA)-dependent postsynaptic mechanism. Activation of 5-HT1A receptor attenuated the excitability of vestibular circuits, as evidenced by reduction of both evoked excitatory and inhibitory transmission (eEPSC and eIPSC), through a presynaptic mechanism. These results reveal that 5-HT1A and 5-HT7 receptors within the MVN exhibit differential modulatory mechanisms but these in concert accomplish synergistic influence on motor coordination.
DescriptionPoster Presentation - Session 286 - Monamines - Topic: B.01. Neurotransmitters and Signaling Molecules - no. 286.23 / C53
Persistent Identifierhttp://hdl.handle.net/10722/261423

 

DC FieldValueLanguage
dc.contributor.authorChan, YS-
dc.contributor.authorHan, L-
dc.contributor.authorLi, YH-
dc.contributor.authorWu, LK-
dc.contributor.authorShum, DKY-
dc.date.accessioned2018-09-14T08:57:53Z-
dc.date.available2018-09-14T08:57:53Z-
dc.date.issued2017-
dc.identifier.citationSociety for Neuroscience 2017 Annual Meeting, Washington DC, USA, 11–15 November 2017. In Neuroscience 2017 Abstracts, p. no. 286.23-
dc.identifier.urihttp://hdl.handle.net/10722/261423-
dc.descriptionPoster Presentation - Session 286 - Monamines - Topic: B.01. Neurotransmitters and Signaling Molecules - no. 286.23 / C53-
dc.description.abstractThe medial vestibular nucleus (MVN) is a major relay station for postural coordination, eye movement control and spatial cognition. Microinjection of 5-HT to the MVN impaired performance of vestibular-mediated motor balance and negative geotaxis in both adult and juvenile (P13-16) rats. We hypothesize that serotonergic neurotransmission modulates the activity of neurons in the MVN circuitry for vestibular-related behaviors. Specific activation of 5-HT7 receptors in the MVN restricted circuit plasticity by abolishing NMDAR-mediated LTD via a protein kinase A (PKA)-dependent postsynaptic mechanism. Activation of 5-HT1A receptor attenuated the excitability of vestibular circuits, as evidenced by reduction of both evoked excitatory and inhibitory transmission (eEPSC and eIPSC), through a presynaptic mechanism. These results reveal that 5-HT1A and 5-HT7 receptors within the MVN exhibit differential modulatory mechanisms but these in concert accomplish synergistic influence on motor coordination.-
dc.languageeng-
dc.publisherSociety for Neuroscience. The Journal's web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings-
dc.relation.ispartofSociety for Neuroscience Abstracts-
dc.rightsSociety for Neuroscience Abstracts. Copyright © Society for Neuroscience.-
dc.titleSerotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors-
dc.typeConference_Paper-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailHan, L: rahanlei@hku.hk-
dc.identifier.emailWu, LK: lwu03@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.hkuros291266-
dc.identifier.spageno. 286.23-
dc.identifier.epageno. 286.23-
dc.publisher.placeUnited States-

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